Evidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 50
- Neutral
- ConsistencyScore™
- unclear
- Not enough independent studies
Estudios de apoyo: Basado en 1 estudio
Add to Evidence TrackerResumen de Investigación
Analyzed using Evidence Intelligence™
Insulin dose reductions improve glucose control during exercise
Última actualización 4 de septiembre de 2026
Key finding
Blood glucose declined by 4.0 ± 2.8 mmol/L during exercise.
This study examined the effects of reduced doses of ultra-rapid-acting insulin aspart (URA-IAsp) and rapid-acting insulin aspart (IAsp) during moderate-intensity exercise, finding similar glucose-lowering effects across different doses.
Quick read
Study at a glance
The essential study design details in one scan.
EvidenceScore™
Moderate
Study type
RCTs
Follow-up
Short-Term (≤3 mo)
Risk of bias
Some Concerns
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Plain-language summary
What this paper says
A plain-language read of the study’s main message and where it applies.
Study focus
This study examined the effects of reduced doses of ultra-rapid-acting insulin aspart (URA-IAsp) and rapid-acting insulin aspart (IAsp) during moderate-intensity exercise, finding similar glucose-lowering effects across different doses.
Clinical relevance
These findings are significant for individuals with diabetes who engage in physical activity, as they suggest that insulin dose adjustments can maintain effective glucose control during exercise. This could help prevent hypoglycemia and improve overall diabetes management.
Keep in mind
Unclear effectiveness due to lack of significant findings. Limited generalizability to broader populations. Sample size and participant characteristics not specified.
Published in
Referencia de la Revista
Publication details and source links for this paper.
Jason PP, Alexander M, Chloe N, et al. Insulin dose reductions around acute moderate-intensity exercise yield similar glucose-lowering effects with URA-IAsp and IAsp. Diabetes, Obesity & Metabolism. 2026;28(4):3002-3010. doi:10.1111/dom.70487
Efectos Principales
Blood glucose declined by −4.0 ± 2.8 mmol/L with 50% URA-IAsp, similar to other conditions (p > 0.05).
Blood glucose reduction was comparable with 75% URA-IAsp, showing no significant differences (p > 0.05).
50% dose of IAsp also resulted in similar glucose reductions (p > 0.05).
75% dose of IAsp showed comparable effects on blood glucose levels (p > 0.05).
Evidence network
How this study fits
Understand where this research contributes within the broader evidence network.
Evidence Context
This study contributes evidence to Insulin aspart and Blood glucose, Blood glucose reduction from start to end of exercise (50% IAsp), Blood glucose reduction from start to end of exercise (75% URA-IAsp).
This study contributes evidence to
Primary intervention
Insulin aspart
Primary outcomes
- Blood glucose
- Blood glucose reduction from start to end of exercise (50% IAsp)
- Blood glucose reduction from start to end of exercise (75% URA-IAsp)
Evidence topics
Primary intervention
Evidence relationships
Intervention and outcome relationships this study adds to the evidence network.
3
Evidence pairs
3
Relationships
2
Evidence topics
contributes_evidence
Editorial context
Why this study matters
See why this paper is useful beyond its individual results.
Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
Moderate contributionModerate confidenceNetwork score: 68
2
Related topics
3
Evidence pairs
886
Related studies
High relevance in at least one topic
Why it is useful
- Contributes to 3 evidence relationships
- Includes primary outcome data
- Linked to 2 direct semantic evidence topics
Topic contributions
Evidence topic
Contributes evidence
Evidence topic
Contributes evidence
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Evidencia principal
Tema de evidencia
Fasting Blood Glucose
matched_outcome
Evidencia relacionada
Tema de evidencia
Glycemic Control
Guardar evidencia
Core evidence
Study findings
The primary outcomes reported in this study.
Blood glucose reduction from start to end of exercise (50% IAsp)
Insulin aspart → Blood glucose reduction from start to end of exercise (50% IAsp)
Insulin aspart → Blood glucose reduction from start to end of exercise (50% IAsp)
Evidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 50
- Neutral
- ConsistencyScore™
- unclear
- Not enough independent studies
Estudios de apoyo: Basado en 1 estudio
Add to Evidence TrackerBlood glucose reduction from start to end of exercise (75% URA-IAsp)
Insulin aspart → Blood glucose reduction from start to end of exercise (75% URA-IAsp)
Insulin aspart → Blood glucose reduction from start to end of exercise (75% URA-IAsp)
Evidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 50
- Neutral
- ConsistencyScore™
- unclear
- Not enough independent studies
Estudios de apoyo: Basado en 1 estudio
Add to Evidence TrackerEvidence Library
Build your evidence library
Save research, organize studies, and quickly find important evidence again.
La Evidencia Sugiere
- Blood glucose levels decreased by −4.0 mmol/L with 50% URA-IAsp.
- No significant differences in glucose reduction across all insulin conditions.
- Study supports insulin dose adjustments during exercise for glucose control.
A quién se aplica
- Individuals with diabetes engaging in moderate-intensity exercise.
- Patients requiring insulin therapy for blood glucose management.
Tener en Cuenta
- Results may not apply to all types of diabetes or exercise intensities.
- Further studies needed to confirm findings in larger, diverse populations.
- Effectiveness of insulin adjustments may vary based on individual responses.
Entre Líneas
- Unclear effectiveness due to lack of significant findings.
- Limited generalizability to broader populations.
- Sample size and participant characteristics not specified.
Evidence Library
Build your evidence library
Save research, organize studies, and quickly find important evidence again.
Connected Evidence
Explore related studies, evidence collections, and research questions.
Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on Insulin aspart and Fasting Glucose, Insulin aspart and Blood glucose reduction from start to end of exercise (50% IAsp).
Relaciones de evidencia relacionadas
Explore in Evidence ExplorerThis study contributes to the evidence on the following intervention-outcome relationships.
Medications
Insulin aspart → Fasting Glucose
Medications
Evidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 50
- Neutral
- ConsistencyScore™
- unclear
- Not enough independent studies
Estudios de apoyo: Basado en 1 estudio
View evidenceMedications
Evidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 50
- Neutral
- ConsistencyScore™
- unclear
- Not enough independent studies
Estudios de apoyo: Basado en 1 estudio
View evidenceIncluido en estas colecciones de evidencia
Curated evidence collections and hubs this study is part of.
Blood glucose reduction from start to end of exercise (50% IAsp) Evidence Hub
All studies measuring Blood glucose reduction from start to end of exercise (50% IAsp)
1 studies
outcome_hubMeasures Blood glucose reduction from start to end of exercise (50% IAsp) as a key outcome.
Fasting Glucose Evidence Hub
All studies measuring Fasting Glucose
1 studies
outcome_hubMeasures Fasting Glucose as a key outcome.
Insulin aspart Evidence Hub
All studies on Insulin aspart
1 studies
intervention_hubContributes to Insulin aspart evidence base.
Recent Diabetes Research
Latest published studies
recency_collection
Published within the last 2 years.
Explora más en Evidence Explorer
Jump to pre-filtered views in Evidence Explorer.
All studies on Insulin aspart and Blood glucose
Intervention: Insulin aspartOutcome: Blood glucose
1 results
All studies on Insulin aspart and Blood glucose reduction from start to end of exercise (50% IAsp)
Intervention: Insulin aspartOutcome: Blood glucose reduction from start to end of exercise (50% IAsp)
1 results
All studies on Insulin aspart
Intervention: Insulin aspart
1 results
All studies measuring Blood glucose
Outcome: Blood glucose
1 results
All studies measuring Blood glucose reduction from start to end of exercise (50% IAsp)
Outcome: Blood glucose reduction from start to end of exercise (50% IAsp)
1 results
Questions answered by this study
Generated from the study's connected evidence using Evidence Intelligence™.
Does Insulin aspart improve blood glucose?
Emerging Evidence
Current evidence does not show a clear benefit of Insulin aspart for blood glucose.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
- 1
Blood glucose
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | neutral | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
- Only one supporting study is available.
What evidence is available on Insulin aspart and blood glucose reduction from start to end of exercise (50% iasp)?
Emerging Evidence
Current evidence does not show a clear reduction in blood glucose reduction from start to end of exercise (50% iasp) with Insulin aspart.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
- 1
Blood glucose reduction from start to end of exercise (50% IAsp)
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | neutral | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
- Only one supporting study is available.
What evidence is available on Insulin aspart and blood glucose reduction from start to end of exercise (75% ura-iasp)?
Emerging Evidence
Current evidence does not show a clear reduction in blood glucose reduction from start to end of exercise (75% ura-iasp) with Insulin aspart.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
- 1
Blood glucose reduction from start to end of exercise (75% URA-IAsp)
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | neutral | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
- Only one supporting study is available.
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