Evidence Intelligence™
- ImpactScore™
- 50
- Neutral
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence TrackerResumen de Investigación
Analyzed using Evidence Intelligence™
Inulin-type fructans show little effect on bone health in T2D
Última actualización 3 de julio de 2026
Key finding
Inulin-type fructans did not significantly affect serum concentrations of calcium (0.05 ± 0.02 mmol/L vs. 0.02 ± 0.03 mmol/L, p = 0.324).
This study investigated the effects of inulin-type fructans on serum levels of calcium, magnesium, and vitamin D in individuals with type 2 diabetes, finding no significant improvements.
Quick read
Study at a glance
The essential study design details in one scan.
EvidenceScore™
Moderate
Study type
RCTs
Follow-up
Short-Term (≤3 mo)
Risk of bias
High Risk
Guarda este estudio en tu Evidence Tracker para encontrarlo facilmente cuando lo necesites.
Plain-language summary
What this paper says
A plain-language read of the study's main message and where it applies.
Study focus
This study investigated the effects of inulin-type fructans on serum levels of calcium, magnesium, and vitamin D in individuals with type 2 diabetes, finding no significant improvements.
Clinical relevance
Understanding the effects of dietary supplements like inulin-type fructans on nutrient levels is crucial for managing type 2 diabetes. Since the study showed no significant improvements in serum calcium, magnesium, or vitamin D, it suggests that healthcare providers may need to consider alternative strategies to manage these nutrient levels in diabetic patients.
Keep in mind
The study may have a limited sample size affecting generalizability. The duration of the intervention may not have been sufficient to observe changes. Potential confounding factors were not fully controlled.
Published in
Referencia de la Revista
Publication details and source links for this paper.
Eline B, Wuraola AB, Kristine DM, et al. Inulin-type fructans did not improve serum levels of calcium, magnesium, or vitamin D in people with T2D. Archives of Osteoporosis. 2025;20(1):71. doi:10.1007/s11657-025-01556-x
Efectos Principales
Inulin-type fructans did not significantly affect serum calcium levels (0.05 mmol/L vs. 0.02 mmol/L, p = 0.324).
Inulin-type fructans did not significantly affect serum magnesium levels (0.02 mmol/L vs. 0.00 mmol/L, p = 0.352).
Inulin-type fructans did not significantly affect serum 25(OH) vitamin D levels (-3.60 nmol/L vs. -2.00 nmol/L, p = 0.564).
Evidence network
How this study fits
Understand where this research contributes within the broader evidence network.
Evidence Context
This study contributes evidence to Control (Usual Activity), Inulin-type fructans and Calcium, Serum 25-hydroxyvitamin D, Serum CTX-1, and 2 more.
This study contributes evidence to
Primary intervention
Control (Usual Activity)
Primary outcomes
- Calcium
- Serum 25-hydroxyvitamin D
- Serum CTX-1
Evidence topics
Primary intervention
Primary outcomes
Evidence relationships
Intervention and outcome relationships this study adds to the evidence network.
10
Evidence pairs
10
Relationships
1
Evidence topics
contributes_evidence
Editorial context
Why this study matters
See why this paper is useful beyond its individual results.
Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
Moderate contributionModerate confidenceNetwork score: 63
1
Related topics
10
Evidence pairs
16
Related studies
High relevance in at least one topic
Why it is useful
- Contributes to 10 evidence relationships
- Includes primary outcome data
- Linked to 1 direct semantic evidence topic
Topic contributions
Evidence topic
Contributes evidence
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Evidencia principal
Relación de evidencia
Probiotics and Synbiotics and Adipokine and Angiogenic Markers
Evidencia relacionada
Relación de evidencia
Probiotics and Synbiotics and Kidney Function
Seguir evidencia
Tema de evidencia
Probiotics and Synbiotics
Seguir evidencia
Core evidence
Study findings
The primary outcomes reported in this study.
Serum 25-hydroxyvitamin D
Control (Usual Activity) → Serum 25-hydroxyvitamin D
Control (Usual Activity) → Serum 25-hydroxyvitamin D
Evidence Intelligence™
- ImpactScore™
- 50
- Neutral
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence TrackerEvidence Intelligence™
- ImpactScore™
- 50
- Neutral
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence TrackerEvidence Intelligence™
- ImpactScore™
- 50
- Neutral
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence TrackerEvidence Intelligence™
- ImpactScore™
- 50
- Neutral
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence TrackerEvidence Intelligence™
- ImpactScore™
- 50
- Neutral
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence TrackerSerum 25-hydroxyvitamin D
Inulin-type fructans → Serum 25-hydroxyvitamin D
Inulin-type fructans → Serum 25-hydroxyvitamin D
Evidence Intelligence™
- ImpactScore™
- 50
- Neutral
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence TrackerEvidence Intelligence™
- ImpactScore™
- 50
- Neutral
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence TrackerEvidence Intelligence™
- ImpactScore™
- 50
- Neutral
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence TrackerEvidence Intelligence™
- ImpactScore™
- 50
- Neutral
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
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Evidence Tracker
12 tracked topics
Saved Studies
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Research Notes
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La Evidencia Sugiere
- No significant change in serum calcium levels with inulin-type fructans (p = 0.324).
- No significant change in serum magnesium levels with inulin-type fructans (p = 0.352).
- No significant change in serum 25(OH) vitamin D levels with inulin-type fructans (p = 0.564).
A quién se aplica
- Adults diagnosed with type 2 diabetes.
- Individuals looking to manage their serum nutrient levels.
Tener en Cuenta
- Results may not apply to populations outside of those with type 2 diabetes.
- The findings are based on a specific intervention duration.
- Further research is needed to explore long-term effects and different populations.
Entre Líneas
- The study may have a limited sample size affecting generalizability.
- The duration of the intervention may not have been sufficient to observe changes.
- Potential confounding factors were not fully controlled.
Save this study
Keep this study in your Evidence Tracker so you can easily find it again whenever you need it.
Today's Activity
Your Evidence Workspace
Saved this study
Your free account becomes your personal diabetes evidence workspace.
Evidence Tracker
12 tracked topics
Saved Studies
48 studies
Research Notes
Coming Soon
Weekly Evidence Digest
Coming Soon
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Connected Evidence
Explore related studies, evidence collections, and research questions.
Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on Control (Usual Activity) and Calcium, Control (Usual Activity) and Adipokine and Angiogenic Markers.
Relaciones de evidencia relacionadas
Explore in Evidence ArchiveThis study contributes to the evidence on the following intervention-outcome relationships.
Control
Detailed evidenceEvidence Intelligence™
- ImpactScore™
- 50
- Neutral
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
View evidenceControl
Detailed evidenceEvidence Intelligence™
- ImpactScore™
- 50
- Neutral
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
View evidenceIncluido en estas colecciones de evidencia
Curated evidence collections and hubs this study is part of.
Adipokine and Angiogenic Markers Evidence Hub
All studies measuring Adipokine and Angiogenic Markers
1 studies
outcome_hubMeasures Adipokine and Angiogenic Markers as a key outcome.
Calcium Evidence Hub
All studies measuring Calcium
1 studies
outcome_hubMeasures Calcium as a key outcome.
Control (Usual Activity) Evidence Hub
All studies on Control (Usual Activity)
1 studies
intervention_hubContributes to Control (Usual Activity) evidence base.
Recent Diabetes Research
Latest published studies
recency_collection
Published within the last 2 years.
Explora más en el archivo de evidencia
Jump to pre-filtered views in the evidence archive.
All studies on Control (Usual Activity) and Calcium
Intervention: Control (Usual Activity)Outcome: Calcium
1 results
All studies on Control (Usual Activity) and Serum 25-hydroxyvitamin D
Intervention: Control (Usual Activity)Outcome: Serum 25-hydroxyvitamin D
1 results
All studies on Control (Usual Activity)
Intervention: Control (Usual Activity)
1 results
All studies measuring Calcium
Outcome: Calcium
1 results
All studies measuring Serum 25-hydroxyvitamin D
Outcome: Serum 25-hydroxyvitamin D
1 results
Questions answered by this study
Generated from the study's connected evidence using Evidence Intelligence™.
Does Probiotics and Synbiotics improve adipokine and angiogenic markers?
Strong Evidence
Probiotics and Synbiotics may improve Adipokine and Angiogenic Markers.
ConsistencyScore™: Results are generally consistent across studies.
Ranked evidence signals
- 1
Serum 25-hydroxyvitamin D
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | neutral | ConsistencyScore™ Unclear | 1 study
- 2
Serum magnesium
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | neutral | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on 10 supporting studies with generally consistent results and a positive effect signal.
Limitations
- Population details are unavailable.
Does Probiotics and Synbiotics improve kidney function?
Moderate Evidence
Probiotics and Synbiotics may improve Kidney Function.
ConsistencyScore™: Results are mixed and should be interpreted cautiously.
Evidence caveat: The available evidence reports mixed findings.
Ranked evidence signals
- 1
Serum CTX-1
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | neutral | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is cautious because the available studies report mixed findings.
Limitations
- Only a small number of supporting studies are available.
- Population details are unavailable.
Does Control (Usual Activity) improve calcium?
Emerging Evidence
Current evidence does not show a clear benefit of Control (Usual Activity) for Calcium.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
- 1
Calcium
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | neutral | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
- Only one supporting study is available.
- Consistency cannot yet be determined.
- Population details are unavailable.
Does Control (Usual Activity) improve serum 25-hydroxyvitamin d?
Emerging Evidence
Current evidence does not show a clear benefit of Control (Usual Activity) for Serum 25-hydroxyvitamin D.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
- 1
Serum 25-hydroxyvitamin D
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | neutral | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
- Only one supporting study is available.
- Consistency cannot yet be determined.
- Population details are unavailable.
Next steps
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