Resumen de Investigación

Vitamin D supplementation reduces neonatal birth weight in gestational diabetes

Moderate confidence

Low bias

Última actualización 19 de junio de 2026

Conclusión Clave:

This study examined the effects of vitamin D supplementation on oxidative stress, inflammation, and pregnancy outcomes in women with gestational diabetes mellitus, finding significant changes in several biomarkers.

Estudio de un Vistazo

Qué se estudió

Vitamin D supplementation in women with gestational diabetes.

Participantes

Young Adult (19–39), Middle Aged (40-64)

Female

with Gestational Diabetes

Intervención

Vitamin D supplementation, Placebo

Resultados

Serum 25(OH)D, Calcium, Oxidative stress markers (GSH), Malondialdehyde (MDA), C-reactive protein, Neonatal birth weight, Incidence of macrosomia, Fasting glucose changes

Financiamiento

No Patrocinado por la Industria

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Efectos Principales

Vitamin D supplementation significantly increased serum 25(OH)D levels by 6.38 ng/mL (p=0.021).

Calcium levels increased by 0.86 mg/dL (p=0.001) with vitamin D supplementation.

Vitamin D supplementation decreased MDA levels by 0.89 μmol/L (p=0.003) and hs-CRP levels by 1.28 mg/L (p=0.019).

Resumen de Evidencia

Intervention	Outcome	Measured Change	Study Effect
Vitamin D supplementation (Supplements)	C-reactive protein (Metabolic Health)	Decrease	Strong
Vitamin D supplementation (Supplements)	Calcium (Metabolic Health)	Increase	Strong
Vitamin D supplementation (Supplements)	Fasting Plasma Glucose (FPG) (Glycemic Control)	No Change	Unclear
Vitamin D supplementation (Supplements)	Incidence of macrosomia (Clinical Outcomes)	Decrease	Strong
Vitamin D supplementation (Supplements)	Malondialdehyde (MDA) (Metabolic Health)	Decrease	Strong
Vitamin D supplementation (Supplements)	Neonatal birth weight (Weight & Anthropometrics)	Decrease	Strong
Vitamin D supplementation (Supplements)	Oxidative stress markers (GSH) (Metabolic Health)	Increase	Strong
Vitamin D supplementation (Supplements)	Serum 25-hydroxyvitamin D (Metabolic Health)	Increase	Strong

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La Evidencia Sugiere

Vitamin D increased serum 25(OH)D levels significantly.
Calcium levels rose notably with vitamin D supplementation.
Oxidative stress markers showed significant improvement.

A quién se aplica

Pregnant women diagnosed with gestational diabetes mellitus.
Women in the study were likely in their second or third trimester.

Tener en Cuenta

The study's findings may not apply to all populations of pregnant women.
Further research is needed to understand the implications of lower neonatal birth weight.
Effectiveness of vitamin D supplementation on fasting glucose remains uncertain.

Entre Líneas

The effectiveness of vitamin D supplementation remains unclear for some outcomes.
The study may have limited generalizability due to specific population characteristics.
No significant differences were found in fasting glucose changes.

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Referencia de la Revista

Yifan L, Liying L, Jiani Y, Qin Y. Effects of Vitamin D Supplementation on Oxidative Stress, Inflammation, and Pregnancy Outcomes in Women with Gestational Diabetes Mellitus. Endocrine Connections. 2026;15(2):e250932. doi:10.1530/EC-25-0932

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Connected Evidence

Discover how this study fits into the broader diabetes evidence landscape.

This study contributes to evidence on Vitamins, Minerals, and Nutraceuticals and Serum 25-hydroxyvitamin D, Vitamins, Minerals, and Nutraceuticals and Inflammatory and Oxidative Stress.