Última actualización 25 de agosto de 2026
Key finding
HR: 0.74; 95% CI: 0.57 to 0.97, p = 0.026
The study examined the long-term outcomes of individuals with impaired glucose tolerance who underwent a lifestyle intervention, finding significant reductions in mortality and cardiovascular events compared to those with diabetes.
Quick read
The essential study design details in one scan.
EvidenceScore™
Moderate
Study type
RCTs
Follow-up
Extended (5–20+ y)
Risk of bias
High Risk
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Plain-language summary
A plain-language read of the study’s main message and where it applies.
Study focus
The study examined the long-term outcomes of individuals with impaired glucose tolerance who underwent a lifestyle intervention, finding significant reductions in mortality and cardiovascular events compared to those with diabetes.
These findings highlight the importance of lifestyle interventions in preventing serious health issues in individuals at risk for diabetes. By reducing the risk of all-cause mortality and cardiovascular events, such interventions can improve quality of life and reduce healthcare costs associated with diabetes-related complications.
Limited generalizability due to specific population characteristics Unclear effectiveness of the intervention in diverse settings Potential confounding factors not fully controlled
Published in
Publication details and source links for this paper.
Xin Q, Jinping W, Qiuhong G, et al. Years of Non-Diabetes Status After Impaired Glucose Tolerance and Long-Term Outcomes. PLOS Medicine. 2024;21(7):e1004419. doi:10.1371/journal.pmed.1004419
Significantly lower risk of all-cause mortality (HR: 0.74, p = 0.026)
Significantly lower risk of cardiovascular events (HR: 0.63, p < 0.001)
Significantly lower risk of microvascular complications (HR: 0.62, p = 0.004)
Significant reduction in cardiovascular death observed after 6 years (HR: 0.56, p = 0.002)
Evidence network
Understand where this research contributes within the broader evidence network.
This study contributes evidence to Complex lifestyle intervention and All-cause mortality, Cardiovascular death, Cardiovascular events, and 1 more.
This study contributes evidence to
Primary intervention
Complex lifestyle intervention
Primary outcomes
Primary intervention
Primary outcomes
Intervention and outcome relationships this study adds to the evidence network.
Editorial context
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Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
2
Related topics
4
Evidence pairs
131
Related studies
Evidence topic
Contributes evidence
Evidence topic
Contributes evidence
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Evidencia principal
Relación de evidencia
Evidencia relacionada
Tema de evidencia
Guardar evidencia
Tema de evidencia
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Core evidence
The primary outcomes reported in this study.
Complex lifestyle intervention → All-cause mortality
Complex lifestyle intervention → All-cause mortality
Complex lifestyle intervention → Cardiovascular death
Complex lifestyle intervention → Cardiovascular death
Complex lifestyle intervention → Cardiovascular events
Complex lifestyle intervention → Cardiovascular events
Complex lifestyle intervention → Diabetic microvascular complication multimorbidity
Complex lifestyle intervention → Diabetic microvascular complication multimorbidity
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Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on Diabetes Self-Management Education and Support (DSMES) Programs and Diabetic microvascular complication multimorbidity, Diabetes Self-Management Education and Support (DSMES) Programs and Cardiovascular Outcomes.
This study contributes to the evidence on the following intervention-outcome relationships.
Behavioral & Lifestyle
Behavioral & Lifestyle
Curated evidence collections and hubs this study is part of.
All studies on Diabetes Self-Management Education and Support (DSMES) Programs
Contributes to Diabetes Self-Management Education and Support (DSMES) Programs evidence base.
All studies measuring Diabetic microvascular complication multimorbidity
Measures Diabetic microvascular complication multimorbidity as a key outcome.
All studies measuring Cardiovascular Outcomes
Measures Cardiovascular Outcomes as a key outcome.
Latest published studies
Published within the last 2 years.
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2 results
1 results
2 results
2 results
1 results
Generated from the study's connected evidence using Evidence Intelligence™.
Diabetes Self-Management Education and Support (DSMES) Programs appears to improve Cardiovascular Outcomes.
ConsistencyScore™: Results are generally consistent across studies.
Ranked evidence signals
All-cause mortality
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Cardiovascular events
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Cardiovascular death
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | moderate negative | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on 4 supporting studies with generally consistent results and a positive effect signal.
Limitations
Complex lifestyle intervention may improve Diabetic microvascular complication multimorbidity.
ConsistencyScore™: Results are mixed and should be interpreted cautiously.
Ranked evidence signals
Diabetic microvascular complication multimorbidity
EvidenceScore™ Moderate | EvidenceScore™ 69.0 | moderate positive | ConsistencyScore™ Mixed | 1 study
Why this answer: This answer is cautious because the available studies report mixed findings.
Limitations
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