Última actualización 21 de agosto de 2026
Key finding
The HDMS was significantly improved by the 6-day Mediterranean diet intervention (mean increase: 1.3 SD, 95% CI 1.1–1.4, p=6E-25).
This pilot study investigated the effects of a Mediterranean diet on older adults, finding significant improvements in the healthy dietary metabolic signature.
Quick read
The essential study design details in one scan.
EvidenceScore™
Moderate
Study type
RCTs
Follow-up
Short-Term (≤3 mo)
Risk of bias
Some Concerns
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Plain-language summary
A plain-language read of the study’s main message and where it applies.
Study focus
This pilot study investigated the effects of a Mediterranean diet on older adults, finding significant improvements in the healthy dietary metabolic signature.
The findings highlight the potential of the Mediterranean diet as a simple dietary intervention to enhance metabolic health in older adults. Given the increasing prevalence of metabolic disorders in aging populations, these results suggest that adopting such a diet could be a practical approach to improve health outcomes and reduce disease risk.
Small sample size limits generalizability Short duration of intervention may not reflect long-term effects Single-arm study design lacks a control group for comparison
Published in
Publication details and source links for this paper.
E. S, F. O, U. E, et al. The Mediterranean Diet Improves the Healthy Dietary Metabolic Signature in Older Adults: A Pilot Study. Metabolomics. 2024;20(4):82. doi:10.1007/s11306-024-02154-7
Healthy dietary metabolic signature improved by 1.3 SD (p=6E-25)
Pipecolate increased by 1.6 (p=8E-26)
Piperine decreased by -1.4 (p=1E-21)
Hippurate increased by 1.3 (p=9E-17)
Evidence network
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This study contributes evidence to Mediterranean diet and Change in 3-Methyl-histidine levels, Change in 7-Methylguanine Levels, Change in Acetylornithine Levels, and 10 more.
This study contributes evidence to
Primary intervention
Mediterranean diet
Primary outcomes
Primary intervention
Intervention and outcome relationships this study adds to the evidence network.
Editorial context
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Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
0
Related topics
13
Evidence pairs
0
Related studies
Core evidence
The primary outcomes reported in this study.
Mediterranean diet → Change in 3-Methyl-histidine levels
Mediterranean diet → Change in 3-Methyl-histidine levels
Mediterranean diet → Change in 7-Methylguanine Levels
Mediterranean diet → Change in 7-Methylguanine Levels
Mediterranean diet → Change in Acetylornithine Levels
Mediterranean diet → Change in Acetylornithine Levels
Mediterranean diet → Change in beta-carotene levels
Mediterranean diet → Change in beta-carotene levels
Mediterranean diet → Change in C11:0-acylcarnitine levels
Mediterranean diet → Change in C11:0-acylcarnitine levels
Mediterranean diet → Change in C14:1-acylcarnitine levels
Mediterranean diet → Change in C14:1-acylcarnitine levels
Mediterranean diet → Change in caffeine levels
Mediterranean diet → Change in caffeine levels
Mediterranean diet → Change in Healthy Dietary Metabolic Signature (HDMS)
Mediterranean diet → Change in Healthy Dietary Metabolic Signature (HDMS)
Mediterranean diet → Change in hippurate levels
Mediterranean diet → Change in hippurate levels
Mediterranean diet → Change in Paraxanthine Levels
Mediterranean diet → Change in Paraxanthine Levels
Mediterranean diet → Change in pipecolate levels
Mediterranean diet → Change in pipecolate levels
Mediterranean diet → Change in piperine levels
Mediterranean diet → Change in piperine levels
Mediterranean diet → Erythrocyte sedimentation rate
Mediterranean diet → Erythrocyte sedimentation rate
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Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on Mediterranean diet and Change in 3-Methyl-histidine levels, Mediterranean diet and Change in 7-Methylguanine Levels.
This study contributes to the evidence on the following intervention-outcome relationships.
Diet and Nutrition
Diet and Nutrition
Curated evidence collections and hubs this study is part of.
All studies measuring Change in 3-Methyl-histidine levels
Measures Change in 3-Methyl-histidine levels as a key outcome.
All studies measuring Change in 7-Methylguanine Levels
Measures Change in 7-Methylguanine Levels as a key outcome.
All studies on Mediterranean diet
Contributes to Mediterranean diet evidence base.
Latest published studies
Published within the last 2 years.
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1 results
1 results
1 results
1 results
1 results
Generated from the study's connected evidence using Evidence Intelligence™.
Mediterranean diet appears to improve Change in 7-Methylguanine Levels.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Change in 7-Methylguanine Levels
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Mediterranean diet appears to improve Change in Acetylornithine Levels.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Change in Acetylornithine Levels
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Mediterranean diet appears to improve Change in C11:0-acylcarnitine levels.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Change in C11:0-acylcarnitine levels
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Mediterranean diet appears to improve Change in C14:1-acylcarnitine levels.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Change in C14:1-acylcarnitine levels
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
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