Evidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 25
- Negative
- ConsistencyScore™
- unclear
- Not enough independent studies
Estudios de apoyo: Basado en 1 estudio
Add to Evidence TrackerResumen de Investigación
Analyzed using Evidence Intelligence™
Metformin reduces fetal weight in women with gestational diabetes
Última actualización 9 de septiembre de 2026
Key finding
P-selectin levels were significantly higher in the metformin group (68.9 ± 14.4 vs 60.6 ± 11.3; P-value = 0.006)
This study investigated the effects of metformin on platelet dysfunction in women with gestational diabetes mellitus, finding significant differences in P-selectin levels and birth weight.
Quick read
Study at a glance
The essential study design details in one scan.
EvidenceScore™
Moderate
Study type
RCTs
Follow-up
Medium-Term (3–12 mo)
Risk of bias
Some Concerns
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Plain-language summary
What this paper says
A plain-language read of the study’s main message and where it applies.
Study focus
This study investigated the effects of metformin on platelet dysfunction in women with gestational diabetes mellitus, finding significant differences in P-selectin levels and birth weight.
Clinical relevance
These findings suggest that metformin may influence platelet function and fetal growth in women with gestational diabetes, which could have important implications for maternal and neonatal health. Understanding these effects is crucial for optimizing treatment strategies and improving outcomes for both mothers and their infants.
Keep in mind
Unclear effectiveness of metformin on other measured outcomes. Limited generalizability due to specific population focus. Potential confounding factors not controlled for in the study.
Published in
Referencia de la Revista
Publication details and source links for this paper.
Panisa H, Rattanaporn S, Thidarat J, et al. The Effect of Metformin on Platelet Dysfunction in Women with Gestational Diabetes Mellitus: A Randomized Controlled Trial. Endocrine Connections. 2022;11(4):e220110. doi:10.1530/EC-22-0110
Efectos Principales
P-selectin levels were significantly higher in the metformin group (68.9 ± 14.4 vs 60.6 ± 11.3; P-value = 0.006)
Birth weight was significantly lower in the metformin group (3018 ± 364 g vs 3204 ± 393 g; P-value = 0.037)
Evidence network
How this study fits
Understand where this research contributes within the broader evidence network.
Evidence Context
This study contributes evidence to Metformin and Birth weight z score, P-selectin, Urinary 8-isoprostane levels.
This study contributes evidence to
Primary intervention
Metformin
Primary outcomes
- Birth weight z score
- P-selectin
- Urinary 8-isoprostane levels
Evidence topics
Primary intervention
Primary outcomes
Evidence relationships
Intervention and outcome relationships this study adds to the evidence network.
3
Evidence pairs
3
Relationships
1
Evidence topics
contributes_evidence
Editorial context
Why this study matters
See why this paper is useful beyond its individual results.
Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
Moderate contributionModerate confidenceNetwork score: 59
1
Related topics
3
Evidence pairs
41
Related studies
High relevance in at least one topic
Why it is useful
- Contributes to 3 evidence relationships
- Includes primary outcome data
- Linked to 1 direct semantic evidence topic
Topic contributions
Evidence topic
Contributes evidence
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Evidencia principal
Tema de evidencia
Metformin
matched_intervention
Core evidence
Study findings
The primary outcomes reported in this study.
Evidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 50
- Neutral
- ConsistencyScore™
- unclear
- Not enough independent studies
Estudios de apoyo: Basado en 1 estudio
Add to Evidence TrackerUrinary 8-isoprostane levels
Metformin → Urinary 8-isoprostane levels
Metformin → Urinary 8-isoprostane levels
Evidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 50
- Neutral
- ConsistencyScore™
- unclear
- Not enough independent studies
Estudios de apoyo: Basado en 1 estudio
Add to Evidence TrackerEvidence Library
Build your evidence library
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La Evidencia Sugiere
- Metformin increased P-selectin levels by 8.3 ng/mL (P-value = 0.006).
- Birth weight decreased by 186 g in the metformin group (P-value = 0.037).
- No significant change in 8-isoprostane levels (P-value = 0.379).
A quién se aplica
- Women diagnosed with gestational diabetes mellitus.
- Pregnant individuals at risk for platelet dysfunction.
Tener en Cuenta
- Results may not apply to women outside the study population.
- Further research is needed to explore long-term effects.
- The study did not assess all potential confounding variables.
Entre Líneas
- Unclear effectiveness of metformin on other measured outcomes.
- Limited generalizability due to specific population focus.
- Potential confounding factors not controlled for in the study.
Evidence Library
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Connected Evidence
Explore related studies, evidence collections, and research questions.
Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on Metformin Therapies and Birth weight z score, Metformin Therapies and P-selectin.
Relaciones de evidencia relacionadas
Explore in Evidence ExplorerThis study contributes to the evidence on the following intervention-outcome relationships.
Medications
Metformin Therapies → Birth weight z score
Medications
Evidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 25
- Negative
- ConsistencyScore™
- unclear
- Not enough independent studies
Estudios de apoyo: Basado en 1 estudio
View evidenceMedications
Metformin Therapies → P-selectin
Medications
Evidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 50
- Neutral
- ConsistencyScore™
- unclear
- Not enough independent studies
Estudios de apoyo: Basado en 1 estudio
View evidenceIncluido en estas colecciones de evidencia
Curated evidence collections and hubs this study is part of.
Birth weight z score Evidence Hub
All studies measuring Birth weight z score
1 studies
outcome_hubMeasures Birth weight z score as a key outcome.
Metformin Therapies Evidence Hub
All studies on Metformin Therapies
1 studies
intervention_hubContributes to Metformin Therapies evidence base.
P-selectin Evidence Hub
All studies measuring P-selectin
1 studies
outcome_hubMeasures P-selectin as a key outcome.
Explora más en Evidence Explorer
Jump to pre-filtered views in Evidence Explorer.
All studies on Metformin and Birth weight z score
Intervention: MetforminOutcome: Birth weight z score
1 results
All studies on Metformin and P-selectin
Intervention: MetforminOutcome: P-selectin
1 results
All studies on Metformin
Intervention: Metformin
1 results
All studies measuring Birth weight z score
Outcome: Birth weight z score
1 results
All studies measuring P-selectin
Outcome: P-selectin
1 results
Questions answered by this study
Generated from the study's connected evidence using Evidence Intelligence™.
Does Metformin improve p-selectin?
Emerging Evidence
Current evidence does not show a clear benefit of Metformin for p-selectin.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
- 1
P-selectin
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | neutral | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
- Only one supporting study is available.
Does Metformin improve urinary 8-isoprostane levels?
Emerging Evidence
Current evidence does not show a clear benefit of Metformin for urinary 8-isoprostane levels.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
- 1
Urinary 8-isoprostane levels
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | neutral | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
- Only one supporting study is available.
Does Metformin improve birth weight z score?
Emerging Evidence
Metformin may worsen birth weight z score or be associated with harm.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
- 1
Birth weight z score
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | moderate negative | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
- Only one supporting study is available.
Next steps
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Read related research summaries.
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