Resumen de Investigación
Mulberry Twig Alkaloids Improve Glycemic Variability in Type 2 Diabetes
Moderate confidence
Low bias
Última actualización 15 de junio de 2026Conclusión Clave:
This study evaluated the effects of mulberry twig alkaloids combined with continuous subcutaneous insulin infusion on glycemic variability in type 2 diabetes patients, finding significant improvements in several glycemic metrics.
Estudio de un Vistazo
Participantes
Intervención
Mulberry twig alkaloids plus continuous subcutaneous insulin infusion, Continuous subcutaneous insulin infusion
Resultados
Mean blood glucose, Standard deviation of blood glucose, Coefficient of variation, Mean amplitude of glycemic excursions, Mean of daily differences, Time in range, Time above range, Time below range, Traditional Chinese Medicine symptom score
Financiamiento
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Efectos Principales
Mean blood glucose (MBG) was reduced by 1.18 mmol/L (P < 0.05).
Standard deviation of blood glucose (SDBG) decreased by 0.07 mmol/L (P < 0.05).
Time in range (TIR) increased significantly (P < 0.01).
Resumen de Evidencia
| Intervention | Outcome | Measured Change | Study Effect |
|---|---|---|---|
 Insulin pump plus Mulberry twig extract therapy (Medications) |  Blood glucose (Glycemic Control) | Decrease | Strong |
Insulin pump plus Mulberry twig extract therapy (Medications) | Coefficient of variation (Glycemic Control) | Decrease | Strong |
Insulin pump plus Mulberry twig extract therapy (Medications) | Glucose variability (Glycemic Control) | Decrease | Strong |
Insulin pump plus Mulberry twig extract therapy (Medications) | Mean amplitude of glycemic excursions (MAGE) (Glycemic Control) | Decrease | Strong |
Insulin pump plus Mulberry twig extract therapy (Medications) | Mean of daily differences (MODD) (Glycemic Control) | Decrease | Strong |
Insulin pump plus Mulberry twig extract therapy (Medications) | Time above range (Glycemic Control) | Decrease | Strong |
Insulin pump plus Mulberry twig extract therapy (Medications) | Time below range (Glycemic Control) | Decrease | Strong |
Insulin pump plus Mulberry twig extract therapy (Medications) | Time in range (Glycemic Control) | Increase | Strong |
Insulin pump plus Mulberry twig extract therapy (Medications) |  Traditional Chinese medicine symptom score (Patient-Reported) | Decrease | Strong |
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La Evidencia Sugiere
- MTA reduced mean blood glucose by 1.18 mmol/L (P < 0.001).
- MTA decreased standard deviation of blood glucose by 0.07 mmol/L (P < 0.001).
- MTA significantly improved time in range (P < 0.01).
A quién se aplica
- Adults diagnosed with type 2 diabetes.
- Patients currently using continuous subcutaneous insulin infusion.
Tener en Cuenta
- Results may not be generalizable to all populations with diabetes.
- Further research is needed to confirm long-term benefits.
- The study's design did not include a placebo control.
Entre Líneas
- The sample size and demographic diversity were not specified.
- Long-term effects of MTA were not assessed.
- The study did not include a placebo group.
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Referencia de la Revista
Yu Z, Yangkui Z. The Effect of Mulberry Twig Alkaloids Combined with Continuous Subcutaneous Insulin Infusion on Glycemic Variability in Patients with Type 2 Diabetes. Medical Science Monitor: International Medical Journal of Experimental and Clinical Research. 2026;32:e951024. doi:10.12659/MSM.951024
Connected Evidence
Discover how this study fits into the broader diabetes evidence landscape.
This study contributes to evidence on Insulin Delivery Systems and Glycemic Control, Insulin Delivery Systems and Glycemic Control.
Relaciones de evidencia relacionadas
Explore in Evidence ArchiveThis study contributes to the evidence on the following intervention–outcome relationships.
Incluido en estas colecciones de evidencia
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Key clinical and research questions this study contributes to.
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