Resumen de Investigación

PES treatment improves glucose control in type 2 diabetes patients

Moderate confidence

Low bias

Última actualización 13 de junio de 2026

Conclusión Clave:

This study investigated the impact of peripheral electrical stimulation on glucose control in type 2 diabetes patients, showing significant improvements in nocturnal glucose control.

Estudio de un Vistazo

Participantes

Intervención

Peripheral electrical stimulation (PES)

Resultados

Nocturnal glucose control, Pre-meal mean glucose, Mean daily glucose, Serum cortisol, Insulin, Adverse events

Financiamiento

No Patrocinado por la Industria

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Efectos Principales

Significant reduction in nocturnal glucose levels (−1.3 mg/dL, P < 0.0004)

Improvement in pre-meal mean glucose levels (−2.5 mg/dL, P < 0.02)

Reduction in serum cortisol levels (−20 ng/ml, P < 0.01)

No adverse events recorded

Resumen de Evidencia

Intervention	Outcome	Measured Change	Study Effect
Peripheral electrical stimulation (PES) (Devices & Technology)	Adverse events incidence (Safety)	No Change	Unclear
Peripheral electrical stimulation (PES) (Devices & Technology)	Blood glucose (Glycemic Control)	No Change	Unclear
Peripheral electrical stimulation (PES) (Devices & Technology)	Insulin (Glycemic Control)	No Change	Unclear
Peripheral electrical stimulation (PES) (Devices & Technology)	Nocturnal glucose control (Glycemic Control)	Decrease	Strong
Peripheral electrical stimulation (PES) (Devices & Technology)	Pre-meal mean glucose (Glycemic Control)	Decrease	Strong
Peripheral electrical stimulation (PES) (Devices & Technology)	Serum cortisol (Metabolic Health)	Decrease	Strong

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La Evidencia Sugiere

Nocturnal glucose control improved significantly (P < 0.0004)
Pre-meal glucose levels showed improvement (P < 0.02)
No adverse events were reported during the study

A quién se aplica

Adults diagnosed with type 2 diabetes
Patients experiencing difficulties in glucose control

Tener en Cuenta

Results may not be generalizable to all diabetes populations
Further research needed to confirm long-term effects
Study design limits causal inference on effectiveness

Entre Líneas

Unclear effectiveness for some outcomes
Sample size and population characteristics not specified
Short duration of treatment may limit long-term applicability

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Referencia de la Revista

Merav C, Keren D, Roi S, et al. The Effect of Peripheral Electrical Stimulation on Glucose Control in Patients with Type 2 Diabetes: A Randomized Crossover Trial. PLOS ONE. 2016;11(12):e0168805. doi:10.1371/journal.pone.0168805

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Connected Evidence

Discover how this study fits into the broader diabetes evidence landscape.

This study contributes to evidence on Peripheral electrical stimulation (PES) and Glycemic Control, Peripheral electrical stimulation (PES) and Glycemic Control.