Resumen de Investigación
Analyzed using Evidence Intelligence™

Physical exercise improves glycaemic control in adults with prediabetes.

Última actualización 29 de agosto de 2026

Key finding

The primary outcome variable is the change in MAGE at 15 weeks of follow-up.

This study assessed the efficacy of various physical exercise modalities on glycaemic control in adults with prediabetes, with unclear effectiveness results.

Quick read

Study at a glance

The essential study design details in one scan.

EvidenceScore™

Moderate

Study type

RCTs

Follow-up

Medium-Term (3–12 mo)

Risk of bias

Some Concerns

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Plain-language summary

What this paper says

A plain-language read of the study’s main message and where it applies.

Study focus

This study assessed the efficacy of various physical exercise modalities on glycaemic control in adults with prediabetes, with unclear effectiveness results.

Clinical relevance

Understanding how different exercise modalities influence glycaemic control is crucial for developing effective lifestyle interventions for individuals with prediabetes. This knowledge can help tailor exercise recommendations to improve health outcomes and potentially prevent the progression to type 2 diabetes.

Keep in mind

Effectiveness of interventions remains unclear due to insufficient data. The study may have limited generalizability due to specific population characteristics. Potential confounding factors were not fully addressed in the analysis.

Published in

Referencia de la Revista

Publication details and source links for this paper.

Aina MG, Miquel B, Paula O, et al. To assess the efficacy of different modalities and frequencies of physical exercise on glycaemic control in adults with prediabetes. Metabolites. 2022;12(12):1286. doi:10.3390/metabo12121286

Efectos Principales

The study assessed the change in MAGE at 15 weeks but found unclear effectiveness.

Secondary outcomes included fasting plasma glucose and HbA1c, with unclear results.

Other measured outcomes included quality of life and sleep quality, also showing unclear effectiveness.

Evidence network

How this study fits

Understand where this research contributes within the broader evidence network.

Evidence Context

This study contributes evidence to Aerobic exercise and Change in body composition after 12 weeks of treatment, Fasting Plasma Glucose (FPG), HbA1c, and 7 more.

Primary intervention

Aerobic exercise

Primary outcomes

  • Change in body composition after 12 weeks of treatment
  • Fasting Plasma Glucose (FPG)
  • HbA1c

Evidence relationships

Intervention and outcome relationships this study adds to the evidence network.

10
Evidence pairs
10
Relationships
4
Evidence topics
contributes_evidence

Editorial context

Why this study matters

See why this paper is useful beyond its individual results.

Evidence network role

This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.

Moderate contributionModerate confidenceNetwork score: 68

4

Related topics

10

Evidence pairs

994

Related studies

High relevance in at least one topic

Why it is useful

  • Contributes to 10 evidence relationships
  • Includes primary outcome data
  • Linked to 4 direct semantic evidence topics

Topic contributions

Evidence topic

Contributes evidence

Evidence topic

Contributes evidence

Evidence topic

Contributes evidence

Evidence topic

Contributes evidence

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Evidencia principal

Relación de evidencia

Aerobic Exercise and HbA1c

Evidencia relacionada

Relación de evidencia

Aerobic Exercise and Fasting Glucose

Guardar evidencia

Relación de evidencia

Aerobic Exercise and Body Composition

Guardar evidencia

Core evidence

Study findings

The primary outcomes reported in this study.

Change in body composition after 12 weeks of treatment

Aerobic exercise → Change in body composition after 12 weeks of treatment

Aerobic exercise → Change in body composition after 12 weeks of treatment

Evidence Intelligence™
EvidenceScore™
Emerging
Score 59 · Based on 1 study
ImpactScore™
100
Very Positive
ConsistencyScore™
unclear
Not enough independent studies
Estudios de apoyo: Basado en 1 estudio
Add to Evidence Tracker

Fasting Plasma Glucose (FPG)

Aerobic exercise → Fasting Plasma Glucose (FPG)

Aerobic exercise → Fasting Plasma Glucose (FPG)

Evidence Intelligence™
EvidenceScore™
Strong
Score 79 · Based on 3 studies
ImpactScore™
100
Very Positive
ConsistencyScore™
100
consistent
Estudios de apoyo: Basado en 3 estudios
Add to Evidence Tracker

HbA1c

Aerobic exercise → HbA1c

Aerobic exercise → HbA1c

Evidence Intelligence™
EvidenceScore™
82
Strong
ImpactScore™
80
Positive
ConsistencyScore™
80
consistent
Estudios de apoyo: Basado en 5 estudios
Add to Evidence Tracker

Mean amplitude of glycemic excursions (MAGE)

Aerobic exercise → Mean amplitude of glycemic excursions (MAGE)

Aerobic exercise → Mean amplitude of glycemic excursions (MAGE)

Evidence Intelligence™
EvidenceScore™
Emerging
Score 59 · Based on 1 study
ImpactScore™
100
Very Positive
ConsistencyScore™
unclear
Not enough independent studies
Estudios de apoyo: Basado en 1 estudio
Add to Evidence Tracker

Quality of life

Aerobic exercise → Quality of life

Aerobic exercise → Quality of life

Evidence Intelligence™
EvidenceScore™
Moderate
Score 69 · Based on 2 studies
ImpactScore™
63
Slightly Positive
ConsistencyScore™
35
mixed
Estudios de apoyo: Basado en 2 estudios
Add to Evidence Tracker

REV-ERBα gene expression

Aerobic exercise → REV-ERBα gene expression

Aerobic exercise → REV-ERBα gene expression

Evidence Intelligence™
EvidenceScore™
Emerging
Score 59 · Based on 1 study
ImpactScore™
100
Very Positive
ConsistencyScore™
unclear
Not enough independent studies
Estudios de apoyo: Basado en 1 estudio
Add to Evidence Tracker

Sleep quality

Aerobic exercise → Sleep quality

Aerobic exercise → Sleep quality

Evidence Intelligence™
EvidenceScore™
Moderate
Score 69 · Based on 2 studies
ImpactScore™
63
Slightly Positive
ConsistencyScore™
35
mixed
Estudios de apoyo: Basado en 2 estudios
Add to Evidence Tracker

Systolic blood pressure

Aerobic exercise → Systolic blood pressure

Aerobic exercise → Systolic blood pressure

Evidence Intelligence™
EvidenceScore™
Moderate
Score 69 · Based on 2 studies
ImpactScore™
100
Very Positive
ConsistencyScore™
100
consistent
Estudios de apoyo: Basado en 2 estudios
Add to Evidence Tracker

Time in range

Aerobic exercise → Time in range

Aerobic exercise → Time in range

Evidence Intelligence™
EvidenceScore™
Moderate
Score 69 · Based on 2 studies
ImpactScore™
100
Very Positive
ConsistencyScore™
100
consistent
Estudios de apoyo: Basado en 2 estudios
Add to Evidence Tracker

Triglycerides

Aerobic exercise → Triglycerides

Aerobic exercise → Triglycerides

Evidence Intelligence™
EvidenceScore™
Emerging
Score 59 · Based on 1 study
ImpactScore™
100
Very Positive
ConsistencyScore™
unclear
Not enough independent studies
Estudios de apoyo: Basado en 1 estudio
Add to Evidence Tracker

Evidence Library

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evidence suggest

La Evidencia Sugiere

  • No clear effectiveness was demonstrated for any exercise modality on glycaemic control.
  • Secondary outcomes showed similar unclear results regarding health improvements.
  • Gene expression analysis was included but results were not specified.
who this applies

A quién se aplica

  • Adults with prediabetes.
  • Individuals looking to improve glycaemic control through exercise.
keep in mind

Tener en Cuenta

  • The study's findings are based on a specific population and may not apply broadly.
  • Unclear effectiveness suggests further research is needed to confirm results.
  • The interventions' impact on long-term health outcomes remains uncertain.
between the lines

Entre Líneas

  • Effectiveness of interventions remains unclear due to insufficient data.
  • The study may have limited generalizability due to specific population characteristics.
  • Potential confounding factors were not fully addressed in the analysis.

Evidence Library

Build your evidence library

Save research, organize studies, and quickly find important evidence again.

Connected Evidence

Explore related studies, evidence collections, and research questions.

Relationships organized using the Dediabetes Evidence Intelligence™ framework.

This study contributes to evidence on Aerobic Exercise and HbA1c, Aerobic Exercise and Fasting Glucose.

Relaciones de evidencia relacionadas

Explore in Evidence Explorer

This study contributes to the evidence on the following intervention-outcome relationships.

Questions answered by this study

Generated from the study's connected evidence using Evidence Intelligence™.

Does Aerobic Exercise improve HbA1c?

Strong Evidence

Aerobic Exercise may improve HbA1c.

ConsistencyScore™: Results are consistent across studies.

Ranked evidence signals

  1. 1

    HbA1c

    EvidenceScore™ Strong | EvidenceScore™ 81.6 | moderate positive | ConsistencyScore™ Consistent | 1 study

Why this answer: This answer is based on 8 supporting studies with consistent results and a positive effect signal.

Limitations

  • Population details are unavailable.
8 supporting studiesUpdated: Aug 2026

Does Aerobic Exercise improve fasting glucose?

Strong Evidence

Aerobic Exercise appears to improve Fasting Glucose.

ConsistencyScore™: Results are consistent across studies.

Ranked evidence signals

  1. 1

    Fasting Plasma Glucose (FPG)

    EvidenceScore™ Strong | EvidenceScore™ 79.0 | strong positive | ConsistencyScore™ Consistent | 1 study

Why this answer: This answer is based on 8 supporting studies with consistent results and a positive effect signal.

Limitations

  • Population details are unavailable.
8 supporting studiesUpdated: Aug 2026

Does Aerobic Exercise improve body composition?

Strong Evidence

Aerobic Exercise appears to improve Body Composition.

ConsistencyScore™: Results are consistent across studies.

Ranked evidence signals

  1. 1

    Change in body composition after 12 weeks of treatment

    EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study

Why this answer: This answer is based on 5 supporting studies with consistent results and a positive effect signal.

Limitations

  • Population details are unavailable.
5 supporting studiesUpdated: Aug 2026

Does Aerobic Exercise improve cgm time in range?

Strong Evidence

Aerobic Exercise may improve CGM Time in Range.

ConsistencyScore™: Results are mixed and should be interpreted cautiously.

Evidence caveat: The available evidence reports mixed findings.

Ranked evidence signals

  1. 1

    Time in range

    EvidenceScore™ Moderate | EvidenceScore™ 69.0 | strong positive | ConsistencyScore™ Consistent | 1 study

Why this answer: This answer is cautious because the available studies report mixed findings.

Limitations

  • Population details are unavailable.
6 supporting studiesUpdated: Aug 2026
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