Evidence Intelligence™
- EvidenceScore™
- 82
- Strong
- ImpactScore™
- 79
- Positive
- ConsistencyScore™
- 100
- consistent
Estudios de apoyo: Basado en 9 estudios
Add to Evidence TrackerResumen de Investigación
Analyzed using Evidence Intelligence™
Pioglitazone improves glycemic control compared to dapagliflozin in type 2 diabetes
Última actualización 27 de agosto de 2026
Key finding
The adjusted mean change of HbA1c at week 26 was -0.75% with pioglitazone.
This study compared the efficacy and safety of pioglitazone and dapagliflozin when added to metformin plus alogliptin in patients with type 2 diabetes.
Quick read
Study at a glance
The essential study design details in one scan.
EvidenceScore™
Moderate
Study type
RCTs
Follow-up
Short-Term (≤3 mo)
Risk of bias
Some Concerns
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Plain-language summary
What this paper says
A plain-language read of the study’s main message and where it applies.
Study focus
This study compared the efficacy and safety of pioglitazone and dapagliflozin when added to metformin plus alogliptin in patients with type 2 diabetes.
Clinical relevance
Understanding the comparative efficacy of pioglitazone and dapagliflozin is crucial for clinicians in tailoring diabetes management strategies. Both medications can be effective options for patients not achieving target HbA1c levels, thus potentially improving overall diabetes control and reducing complications.
Keep in mind
The study did not report p-values for the outcomes. The effectiveness of the interventions was unclear due to limited data. The generalizability of the findings may be limited to the study population.
Published in
Referencia de la Revista
Publication details and source links for this paper.
Kyuho K, Seung-Hyun K, Jae-Seung Y, et al. Efficacy and safety of pioglitazone compared to dapagliflozin when added to metformin plus alogliptin for patients with type 2 diabetes. Scientific Reports. 2025;16:1226. doi:10.1038/s41598-025-30882-w
Efectos Principales
Pioglitazone reduced HbA1c by -0.75% at week 26.
Dapagliflozin reduced HbA1c by -0.88% at week 26.
Insulin resistance decreased by -1.55 units with pioglitazone.
Insulin resistance decreased by -1.96 units with dapagliflozin.
Evidence network
How this study fits
Understand where this research contributes within the broader evidence network.
Evidence Context
This study contributes evidence to Dapagliflozin, Pioglitazone and HbA1c, Insulin resistance, Proportion achieving HbA1c <7.0%.
This study contributes evidence to
Primary intervention
Dapagliflozin
Primary outcomes
- HbA1c
- Insulin resistance
- Proportion achieving HbA1c <7.0%
Primary intervention
Primary outcomes
Evidence relationships
Intervention and outcome relationships this study adds to the evidence network.
6
Evidence pairs
6
Relationships
4
Evidence topics
contributes_evidence
Editorial context
Why this study matters
See why this paper is useful beyond its individual results.
Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
Moderate contributionModerate confidenceNetwork score: 72
4
Related topics
6
Evidence pairs
1067
Related studies
High relevance in at least one topic
Why it is useful
- Contributes to 6 evidence relationships
- Includes primary outcome data
- Linked to 4 direct semantic evidence topics
Topic contributions
Evidence topic
Contributes evidence
Evidence topic
Contributes evidence
Evidence topic
Contributes evidence
Evidence topic
Contributes evidence
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Evidencia principal
Relación de evidencia
SGLT2 Inhibitors and HbA1c
Evidencia relacionada
Relación de evidencia
Thiazolidinediones and HbA1c
Guardar evidencia
Relación de evidencia
SGLT2 Inhibitors and Insulin Resistance
Guardar evidencia
Core evidence
Study findings
The primary outcomes reported in this study.
Evidence Intelligence™
- EvidenceScore™
- 62
- Moderate
- ImpactScore™
- 50
- Neutral
- ConsistencyScore™
- 35
- mixed
Estudios de apoyo: Basado en 2 estudios
Add to Evidence TrackerProportion achieving HbA1c <7.0%
Dapagliflozin → Proportion achieving HbA1c <7.0%
Dapagliflozin → Proportion achieving HbA1c <7.0%
Evidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 50
- Neutral
- ConsistencyScore™
- unclear
- Not enough independent studies
Estudios de apoyo: Basado en 1 estudio
Add to Evidence TrackerEvidence Intelligence™
- EvidenceScore™
- 83
- Strong
- ImpactScore™
- 93
- Very Positive
- ConsistencyScore™
- 100
- consistent
Estudios de apoyo: Basado en 7 estudios
Add to Evidence TrackerEvidence Intelligence™
- EvidenceScore™
- Moderate
- Score 69 · Based on 2 studies
- ImpactScore™
- 50
- Neutral
- ConsistencyScore™
- 35
- mixed
Estudios de apoyo: Basado en 2 estudios
Add to Evidence TrackerProportion achieving HbA1c <7.0%
Pioglitazone → Proportion achieving HbA1c <7.0%
Pioglitazone → Proportion achieving HbA1c <7.0%
Evidence Intelligence™
- EvidenceScore™
- Strong
- Score 79 · Based on 4 studies
- ImpactScore™
- 88
- Very Positive
- ConsistencyScore™
- 75
- consistent
Estudios de apoyo: Basado en 4 estudios
Add to Evidence TrackerEvidence Library
Build your evidence library
Save research, organize studies, and quickly find important evidence again.
La Evidencia Sugiere
- Both pioglitazone and dapagliflozin effectively lowered HbA1c levels.
- Similar proportions of patients achieved HbA1c < 6.5% with both treatments.
- Insulin resistance improved with both medications.
A quién se aplica
- Adults with type 2 diabetes.
- Patients currently on metformin and alogliptin.
Tener en Cuenta
- Results may not apply to patients not on metformin or alogliptin.
- The study's findings are based on a specific population and may not be generalizable.
- Further research is needed to confirm long-term outcomes and safety.
Entre Líneas
- The study did not report p-values for the outcomes.
- The effectiveness of the interventions was unclear due to limited data.
- The generalizability of the findings may be limited to the study population.
Evidence Library
Build your evidence library
Save research, organize studies, and quickly find important evidence again.
Connected Evidence
Explore related studies, evidence collections, and research questions.
Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on Thiazolidinediones and HbA1c, SGLT2 Inhibitors and HbA1c.
Relaciones de evidencia relacionadas
Explore in Evidence ExplorerThis study contributes to the evidence on the following intervention-outcome relationships.
Medications
Thiazolidinediones → HbA1c
Medications
Evidence Intelligence™
- EvidenceScore™
- 83
- Strong
- ImpactScore™
- 93
- Very Positive
- ConsistencyScore™
- 100
- consistent
Estudios de apoyo: Basado en 7 estudios
View evidenceMedications
SGLT2 Inhibitors → HbA1c
Medications
Evidence Intelligence™
- EvidenceScore™
- 82
- Strong
- ImpactScore™
- 79
- Positive
- ConsistencyScore™
- 100
- consistent
Estudios de apoyo: Basado en 9 estudios
View evidenceIncluido en estas colecciones de evidencia
Curated evidence collections and hubs this study is part of.
SGLT2 Inhibitors Evidence Hub
All studies on SGLT2 Inhibitors
9 studies
intervention_hubContributes to SGLT2 Inhibitors evidence base.
HbA1c Evidence Hub
All studies measuring HbA1c
7 studies
outcome_hubMeasures HbA1c as a key outcome.
Thiazolidinediones Evidence Hub
All studies on Thiazolidinediones
7 studies
intervention_hubContributes to Thiazolidinediones evidence base.
Recent Diabetes Research
Latest published studies
recency_collection
Published within the last 2 years.
Explora más en Evidence Explorer
Jump to pre-filtered views in Evidence Explorer.
All studies on Pioglitazone and HbA1c
Intervention: PioglitazoneOutcome: HbA1c
7 results
All studies on Dapagliflozin and HbA1c
Intervention: DapagliflozinOutcome: HbA1c
9 results
All studies on Pioglitazone
Intervention: Pioglitazone
7 results
All studies on Dapagliflozin
Intervention: Dapagliflozin
9 results
All studies measuring HbA1c
Outcome: HbA1c
7 results
Questions answered by this study
Generated from the study's connected evidence using Evidence Intelligence™.
Do SGLT2 Inhibitors lower HbA1c?
Strong Evidence
SGLT2 Inhibitors may lower HbA1c.
ConsistencyScore™: Results are consistent across studies.
Ranked evidence signals
- 1
HbA1c
EvidenceScore™ Strong | EvidenceScore™ 82.5 | moderate positive | ConsistencyScore™ Consistent | 1 study
- 2
Proportion achieving HbA1c <7.0%
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | neutral | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on 27 supporting studies with consistent results and a positive effect signal.
Do Thiazolidinediones lower HbA1c?
Strong Evidence
Thiazolidinediones appear to lower HbA1c.
ConsistencyScore™: Results are consistent across studies.
Ranked evidence signals
- 1
HbA1c
EvidenceScore™ Strong | EvidenceScore™ 83.2 | strong positive | ConsistencyScore™ Consistent | 1 study
- 2
Proportion achieving HbA1c <7.0%
EvidenceScore™ Strong | EvidenceScore™ 79.0 | strong positive | ConsistencyScore™ Consistent | 1 study
Why this answer: This answer is based on 8 supporting studies with consistent results and a positive effect signal.
Do SGLT2 Inhibitors improve insulin resistance?
Moderate Evidence
SGLT2 Inhibitors may improve insulin resistance.
ConsistencyScore™: Results are generally consistent across studies.
Ranked evidence signals
- 1
Insulin resistance
EvidenceScore™ Moderate | EvidenceScore™ 62.0 | neutral | ConsistencyScore™ Mixed | 1 study
Why this answer: This answer is based on 3 supporting studies with generally consistent results and a positive effect signal.
Do Thiazolidinediones improve insulin resistance?
Moderate Evidence
Current evidence does not show a clear benefit of Thiazolidinediones for insulin resistance.
ConsistencyScore™: Results are mixed and should be interpreted cautiously.
Evidence caveat: The available evidence reports mixed findings.
Ranked evidence signals
- 1
Insulin resistance
EvidenceScore™ Moderate | EvidenceScore™ 69.0 | neutral | ConsistencyScore™ Mixed | 1 study
Why this answer: This answer is cautious because the available studies report mixed findings.
Limitations
- Only a small number of supporting studies are available.
Next steps
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Evidence topics
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Related research
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