Evidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 100
- Very Positive
- ConsistencyScore™
- unclear
- Not enough independent studies
Estudios de apoyo: Basado en 1 estudio
Add to Evidence TrackerResumen de Investigación
Analyzed using Evidence Intelligence™
SRP with Laser Therapy Improves TNF-α Levels in Diabetic Patients
Última actualización 22 de julio de 2026
Key finding
PI decreased significantly from baseline to 8 weeks (mean difference 1.04, p < 0.001).
This study evaluated the impact of Scaling and Root Planing with and without Low Level Laser Therapy on salivary TNF-α levels in patients with periodontitis and type 2 diabetes, finding significant reductions in several clinical parameters.
Quick read
Study at a glance
The essential study design details in one scan.
EvidenceScore™
Moderate
Study type
RCTs
Follow-up
Medium-Term (3–12 mo)
Risk of bias
Some Concerns
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Plain-language summary
What this paper says
A plain-language read of the study’s main message and where it applies.
Study focus
This study evaluated the impact of Scaling and Root Planing with and without Low Level Laser Therapy on salivary TNF-α levels in patients with periodontitis and type 2 diabetes, finding significant reductions in several clinical parameters.
Clinical relevance
These findings are clinically significant as they suggest that integrating Low Level Laser Therapy with standard periodontal treatment may enhance outcomes for patients with both periodontitis and type 2 diabetes, potentially leading to better management of their overall health and reduced inflammation.
Keep in mind
Unclear effectiveness of LLLT compared to SRP alone Limited generalizability due to specific population characteristics Potential confounding factors not controlled in the study
Published in
Referencia de la Revista
Publication details and source links for this paper.
Praneetha P, Vijay KC, Sumanth G. Effect of Scaling and Root Planing with Adjunctive Low Level Laser Therapy on Salivary TNF-α Levels in Patients with Periodontitis and Type 2 Diabetes. Journal of Indian Society of Periodontology. 2022;26(3):236-244. doi:10.4103/jisp.jisp_150_21
Efectos Principales
Plaque Index decreased by 1.04 units (p < 0.001)
Bleeding Index decreased by 1.46 units (p < 0.001)
Salivary TNF-α levels decreased by 5.18 pg/mL (p < 0.001)
Evidence network
How this study fits
Understand where this research contributes within the broader evidence network.
Evidence Context
This study contributes evidence to Photobiomodulation therapy, SRP + OHI and Blood glucose, TNF-α levels, Change in Bleeding Index from Baseline to 8 Weeks, and 3 more.
This study contributes evidence to
Primary intervention
Photobiomodulation therapy
Primary outcomes
- Blood glucose
- TNF-α levels
- Change in Bleeding Index from Baseline to 8 Weeks
Evidence topics
Primary intervention
Evidence relationships
Intervention and outcome relationships this study adds to the evidence network.
6
Evidence pairs
6
Relationships
1
Evidence topics
contributes_evidence
Editorial context
Why this study matters
See why this paper is useful beyond its individual results.
Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
Moderate contributionModerate confidenceNetwork score: 59
1
Related topics
6
Evidence pairs
245
Related studies
High relevance in at least one topic
Why it is useful
- Contributes to 6 evidence relationships
- Includes primary outcome data
- Linked to 1 direct semantic evidence topic
Topic contributions
Evidence topic
Contributes evidence
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Evidencia principal
Tema de evidencia
Glycemic Control
matched_outcome
Core evidence
Study findings
The primary outcomes reported in this study.
Evidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 100
- Very Positive
- ConsistencyScore™
- unclear
- Not enough independent studies
Estudios de apoyo: Basado en 1 estudio
Add to Evidence TrackerChange in Bleeding Index from Baseline to 8 Weeks
SRP + OHI → Change in Bleeding Index from Baseline to 8 Weeks
SRP + OHI → Change in Bleeding Index from Baseline to 8 Weeks
Evidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 100
- Very Positive
- ConsistencyScore™
- unclear
- Not enough independent studies
Estudios de apoyo: Basado en 1 estudio
Add to Evidence TrackerEvidence Intelligence™
- EvidenceScore™
- 84
- Strong
- ImpactScore™
- 83
- Positive
- ConsistencyScore™
- 67
- generally_consistent
Estudios de apoyo: Basado en 6 estudios
Add to Evidence TrackerEvidence Intelligence™
- EvidenceScore™
- 83
- Strong
- ImpactScore™
- 100
- Very Positive
- ConsistencyScore™
- 100
- consistent
Estudios de apoyo: Basado en 7 estudios
Add to Evidence TrackerEvidence Intelligence™
- EvidenceScore™
- Strong
- Score 79 · Based on 4 studies
- ImpactScore™
- 75
- Positive
- ConsistencyScore™
- 35
- mixed
Estudios de apoyo: Basado en 4 estudios
Add to Evidence TrackerEvidence Library
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La Evidencia Sugiere
- Salivary TNF-α levels reduced significantly by 5.18 pg/mL
- Probing Depth decreased significantly by 3.19 mm
- Random Blood Sugar levels decreased significantly by 2.79 units
A quién se aplica
- Adults diagnosed with type 2 diabetes
- Patients suffering from periodontitis
Tener en Cuenta
- Results may not apply to populations outside the study group
- Further research needed to confirm long-term effects
- Study design may limit the applicability of findings
Entre Líneas
- Unclear effectiveness of LLLT compared to SRP alone
- Limited generalizability due to specific population characteristics
- Potential confounding factors not controlled in the study
Evidence Library
Build your evidence library
Save research, organize studies, and quickly find important evidence again.
Connected Evidence
Explore related studies, evidence collections, and research questions.
Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on SRP + OHI and Clinical attachment level, SRP + OHI and Periodontal probing depth.
Relaciones de evidencia relacionadas
Explore in Evidence ExplorerThis study contributes to the evidence on the following intervention-outcome relationships.
Procedures
SRP + OHI → Clinical attachment level
Procedures
Evidence Intelligence™
- EvidenceScore™
- 84
- Strong
- ImpactScore™
- 83
- Positive
- ConsistencyScore™
- 67
- generally_consistent
Estudios de apoyo: Basado en 6 estudios
View evidenceProcedures
SRP + OHI → Periodontal probing depth
Procedures
Evidence Intelligence™
- EvidenceScore™
- 83
- Strong
- ImpactScore™
- 100
- Very Positive
- ConsistencyScore™
- 100
- consistent
Estudios de apoyo: Basado en 7 estudios
View evidenceIncluido en estas colecciones de evidencia
Curated evidence collections and hubs this study is part of.
Periodontal probing depth Evidence Hub
All studies measuring Periodontal probing depth
7 studies
outcome_hubMeasures Periodontal probing depth as a key outcome.
Clinical attachment level Evidence Hub
All studies measuring Clinical attachment level
6 studies
outcome_hubMeasures Clinical attachment level as a key outcome.
SRP + OHI Evidence Hub
All studies on SRP + OHI
6 studies
intervention_hubContributes to SRP + OHI evidence base.
Explora más en Evidence Explorer
Jump to pre-filtered views in Evidence Explorer.
All studies on SRP + OHI and Clinical attachment level
Intervention: SRP + OHIOutcome: Clinical attachment level
6 results
All studies on SRP + OHI and Periodontal probing depth
Intervention: SRP + OHIOutcome: Periodontal probing depth
7 results
All studies on SRP + OHI
Intervention: SRP + OHI
6 results
All studies measuring Clinical attachment level
Outcome: Clinical attachment level
6 results
All studies measuring Periodontal probing depth
Outcome: Periodontal probing depth
7 results
Questions answered by this study
Generated from the study's connected evidence using Evidence Intelligence™.
Does SRP + OHI improve clinical attachment level?
Strong Evidence
SRP + OHI may improve Clinical attachment level.
ConsistencyScore™: Results are generally consistent across studies.
Ranked evidence signals
- 1
Clinical attachment level
EvidenceScore™ Strong | EvidenceScore™ 83.6 | moderate positive | ConsistencyScore™ Generally Consistent | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
- Only one supporting study is available.
- Population details are unavailable.
Does SRP + OHI improve periodontal probing depth?
Strong Evidence
SRP + OHI appears to improve Periodontal probing depth.
ConsistencyScore™: Results are consistent across studies.
Ranked evidence signals
- 1
Periodontal probing depth
EvidenceScore™ Strong | EvidenceScore™ 83.5 | strong positive | ConsistencyScore™ Consistent | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
- Only one supporting study is available.
- Population details are unavailable.
Does SRP + OHI improve plaque index (pi)?
Strong Evidence
SRP + OHI may improve Plaque Index (PI).
ConsistencyScore™: Results are mixed and should be interpreted cautiously.
Evidence caveat: The available evidence reports mixed findings.
Ranked evidence signals
- 1
Plaque Index (PI)
EvidenceScore™ Strong | EvidenceScore™ 79.0 | moderate positive | ConsistencyScore™ Mixed | 1 study
Why this answer: This answer is cautious because the available studies report mixed findings.
Limitations
- Only one supporting study is available.
- Population details are unavailable.
Does Photobiomodulation therapy improve blood glucose?
Emerging Evidence
Photobiomodulation therapy appears to improve Blood glucose.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
- 1
Blood glucose
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
- Only one supporting study is available.
- Consistency cannot yet be determined.
- Population details are unavailable.
Next steps
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Related research
Read related research summaries.
Additional toothbrushing improves oral health in type 2 diabetes patientsNSPT improves plaque index and glycemic control in diabetes.Scaling and root planing improves glycemic control in T2DMSubgingival scaling may improve glycemic control in diabetesAdjunctive therapy improves periodontal outcomes in diabetes patients
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