Resumen de Investigación

Analyzed using Evidence Intelligence™

Suvorexant shows no efficacy for insomnia in type 2 diabetes

Desarrollado con el marco Evidence Intelligence™ de Dediabetes

Última actualización 11 de julio de 2026

Key finding

There were no significant improvements in sTST (p = 0.27).

This study evaluated the efficacy of Suvorexant in improving sleep and health outcomes in individuals with Type 2 diabetes and insomnia, finding no significant improvements.

Quick read

Study at a glance

The essential study design details in one scan.

EvidenceScore™

Moderate

Study type

RCTs

Follow-up

Medium-Term (3–12 mo)

Risk of bias

Some Concerns

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Plain-language summary

What this paper says

A plain-language read of the study’s main message and where it applies.

Study focus

This study evaluated the efficacy of Suvorexant in improving sleep and health outcomes in individuals with Type 2 diabetes and insomnia, finding no significant improvements.

Clinical relevance

Understanding the effectiveness of treatments for insomnia in individuals with Type 2 diabetes is crucial, as sleep disturbances can exacerbate health issues. This study's findings suggest that Suvorexant may not be a beneficial option for improving sleep or related health outcomes in this population, guiding clinicians in treatment decisions.

Keep in mind

Limited sample size may affect generalizability. Short duration of the study may not capture long-term effects. Lack of significant findings raises questions about treatment efficacy.

Published in

Referencia de la Revista

Publication details and source links for this paper.

John WW, Benjamin W, Jordana Z, Bettina BH. Efficacy of Suvorexant in Improving Sleep and Health Outcomes in People with Type 2 Diabetes and Insomnia. Nature and Science of Sleep. 2023;15:1117-1128. doi:10.2147/NSS.S434058

View DOI View on PubMed View on PMC

Efectos Principales

No significant improvements in subjective total sleep time (p = 0.27).

No significant changes in insomnia severity index scores (p = 0.86).

No significant improvements in wake time after sleep onset (p = 0.94).

Evidence network

How this study fits

Understand where this research contributes within the broader evidence network.

Evidence Context

This study contributes evidence to Suvorexant and C-reactive protein, HbA1c, Reduction in Insomnia Symptoms Measured by Insomnia Severity Index (ISI), and 3 more.

This study contributes evidence to

Intervention

Suvorexant

Outcome

C-reactive protein

Evidence topic

HbA1c Reduction

Primary intervention

Suvorexant

Primary outcomes

C-reactive protein
HbA1c
Reduction in Insomnia Symptoms Measured by Insomnia Severity Index (ISI)

Evidence topics

HbA1c Reduction Inflammatory and Vascular Markers

Primary intervention

Suvorexant

Primary outcomes

C-reactive protein HbA1c Reduction in Insomnia Symptoms Measured by Insomnia Severity Index (ISI)

Evidence relationships

Intervention and outcome relationships this study adds to the evidence network.

Evidence pairs

Relationships

Evidence topics

contributes_evidence

Editorial context

Why this study matters

See why this paper is useful beyond its individual results.

Evidence network role

This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.

Moderate contributionModerate confidenceNetwork score: 64

Why it is useful

Contributes to 6 evidence relationships
Includes primary outcome data
Linked to 2 direct semantic evidence topics

Topic contributions

Evidence topic

Contributes evidence

Evidence topic

Contributes evidence

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Evidencia principal

Tema de evidencia

HbA1c Reduction

matched_outcome

Evidencia relacionada

Tema de evidencia

Inflammatory and Vascular Markers

Guardar evidencia

Core evidence

Study findings

The primary outcomes reported in this study.

C-reactive protein

Suvorexant → C-reactive protein

Evidence Intelligence™

EvidenceScore™: Emerging; Score 59 · Based on 1 study
ImpactScore™: 50; Neutral
ConsistencyScore™: unclear; Not enough independent studies

Basado en 1 estudio

Add to Evidence Tracker

HbA1c

Suvorexant → HbA1c

Evidence Intelligence™

EvidenceScore™: Emerging; Score 59 · Based on 1 study
ImpactScore™: 50; Neutral
ConsistencyScore™: unclear; Not enough independent studies

Basado en 1 estudio

Add to Evidence Tracker

Reduction in Insomnia Symptoms Measured by Insomnia Severity Index (ISI)

Suvorexant → Reduction in Insomnia Symptoms Measured by Insomnia Severity Index (ISI)

Evidence Intelligence™

EvidenceScore™: Emerging; Score 59 · Based on 1 study
ImpactScore™: 50; Neutral
ConsistencyScore™: unclear; Not enough independent studies

Basado en 1 estudio

Add to Evidence Tracker

Sleep efficiency

Suvorexant → Sleep efficiency

Evidence Intelligence™

EvidenceScore™: Emerging; Score 59 · Based on 1 study
ImpactScore™: 50; Neutral
ConsistencyScore™: unclear; Not enough independent studies

Basado en 1 estudio

Add to Evidence Tracker

Total sleep time measured in minutes

Suvorexant → Total sleep time measured in minutes

Evidence Intelligence™

EvidenceScore™: Emerging; Score 59 · Based on 1 study
ImpactScore™: 50; Neutral
ConsistencyScore™: unclear; Not enough independent studies

Basado en 1 estudio

Add to Evidence Tracker

Wake time after sleep onset in minutes

Suvorexant → Wake time after sleep onset in minutes

Evidence Intelligence™

EvidenceScore™: Emerging; Score 59 · Based on 1 study
ImpactScore™: 50; Neutral
ConsistencyScore™: unclear; Not enough independent studies

Basado en 1 estudio

Add to Evidence Tracker

Evidence Library

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La Evidencia Sugiere

Suvorexant showed no significant effect on sleep time or quality.
Insomnia severity did not improve with Suvorexant (p = 0.86).
Health markers like HbA1c and CRP remained unchanged.

A quién se aplica

Adults with Type 2 diabetes.
Individuals experiencing insomnia.

Tener en Cuenta

Results may not apply to populations outside the study sample.
Further research is needed to explore other treatment options.
Findings do not support the use of Suvorexant for this condition.

Entre Líneas

Limited sample size may affect generalizability.
Short duration of the study may not capture long-term effects.
Lack of significant findings raises questions about treatment efficacy.

Evidence Library

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Connected Evidence

Explore related studies, evidence collections, and research questions.

Relationships organized using the Dediabetes Evidence Intelligence™ framework.

Desarrollado con el marco Evidence Intelligence™ de Dediabetes

This study contributes to evidence on Suvorexant and Inflammatory Markers, Suvorexant and HbA1c.

Relaciones de evidencia relacionadas

Explore in Evidence Explorer

This study contributes to the evidence on the following intervention-outcome relationships.

Medications

Detailed evidence

Suvorexant → Inflammatory Markers

Medications

Evidence Intelligence™

EvidenceScore™: Emerging; Score 59 · Based on 1 study
ImpactScore™: 50; Neutral
ConsistencyScore™: unclear; Not enough independent studies

Basado en 1 estudio

View evidence

Medications

Detailed evidence

Suvorexant → HbA1c

Medications

Evidence Intelligence™

EvidenceScore™: Emerging; Score 59 · Based on 1 study
ImpactScore™: 50; Neutral
ConsistencyScore™: unclear; Not enough independent studies

Basado en 1 estudio

View evidence

Incluido en estas colecciones de evidencia

Curated evidence collections and hubs this study is part of.

HbA1c Evidence Hub

All studies measuring HbA1c

1 studies

outcome_hub

Measures HbA1c as a key outcome.

Inflammatory Markers Evidence Hub

All studies measuring Inflammatory Markers

1 studies

outcome_hub

Measures Inflammatory Markers as a key outcome.

Suvorexant Evidence Hub

All studies on Suvorexant

1 studies

intervention_hub

Contributes to Suvorexant evidence base.

Explora más en Evidence Explorer

Jump to pre-filtered views in Evidence Explorer.

All studies on Suvorexant and C-reactive protein

Intervention: SuvorexantOutcome: C-reactive protein

1 results

All studies on Suvorexant and HbA1c

Intervention: SuvorexantOutcome: HbA1c

1 results

All studies on Suvorexant

Intervention: Suvorexant

1 results

All studies measuring C-reactive protein

Outcome: C-reactive protein

1 results

All studies measuring HbA1c

Outcome: HbA1c

1 results

Questions answered by this study

Generated from the study's connected evidence using Evidence Intelligence™.

Does Suvorexant improve c-reactive protein?

Emerging Evidence

Current evidence does not show a clear benefit of Suvorexant for C-reactive protein.

ConsistencyScore™: Consistency cannot yet be determined from the available evidence.

Ranked evidence signals

1
C-reactive protein
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | neutral | ConsistencyScore™ Unclear | 1 study

Why this answer: This answer is based on a single supporting study.

Limitations

Only one supporting study is available.
Consistency cannot yet be determined.
Population details are unavailable.

View Full Evidence

Does Suvorexant improve HbA1c?

Emerging Evidence

Current evidence does not show a clear benefit of Suvorexant for HbA1c.

ConsistencyScore™: Consistency cannot yet be determined from the available evidence.

Ranked evidence signals

1
HbA1c
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | neutral | ConsistencyScore™ Unclear | 1 study

Why this answer: This answer is based on a single supporting study.

Limitations

Only one supporting study is available.
Consistency cannot yet be determined.
Population details are unavailable.

View Full Evidence

Does Suvorexant improve reduction in insomnia symptoms measured by insomnia severity index (isi)?

Emerging Evidence

Current evidence does not show a clear benefit of Suvorexant for Reduction in Insomnia Symptoms Measured by Insomnia Severity Index (ISI).

ConsistencyScore™: Consistency cannot yet be determined from the available evidence.

Ranked evidence signals

1
Reduction in Insomnia Symptoms Measured by Insomnia Severity Index (ISI)
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | neutral | ConsistencyScore™ Unclear | 1 study

Why this answer: This answer is based on a single supporting study.

Limitations

Only one supporting study is available.
Consistency cannot yet be determined.
Population details are unavailable.

View Full Evidence

Does Suvorexant improve sleep efficiency?

Emerging Evidence

Current evidence does not show a clear benefit of Suvorexant for Sleep efficiency.

ConsistencyScore™: Consistency cannot yet be determined from the available evidence.

Ranked evidence signals

1
Sleep efficiency
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | neutral | ConsistencyScore™ Unclear | 1 study

Why this answer: This answer is based on a single supporting study.

Limitations

Only one supporting study is available.
Consistency cannot yet be determined.
Population details are unavailable.

View Full Evidence

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Next steps

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Evidence topics

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HbA1c Reduction Evidence Hub Inflammatory and Vascular Markers Evidence Hub

Explore in Evidence Explorer

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All studies on Suvorexant and Total sleep time measured in minutes All studies on Suvorexant and C-reactive protein All studies on Suvorexant and HbA1c All studies on Suvorexant and Reduction in Insomnia Symptoms Measured by Insomnia Severity Index (ISI)

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Read related research summaries.

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