Resumen de Investigación

Tighter glycaemic targets may reduce serious infant morbidity

Moderate confidence
Low bias
Última actualización 15 de junio de 2026

Conclusión Clave:

This study evaluated the impact of tighter glycaemic control in women with gestational diabetes. It found a reduction in serious health outcomes for infants but an increase in serious maternal health outcomes.

Estudio de un Vistazo

Participantes

Intervención

Tighter glycemic control, Less tight glycemic control

Resultados

Large for gestational age, Composite serious health outcome for the infant, Serious maternal health outcome, Pharmacological treatment requirement

Financiamiento

No Patrocinado por la Industria

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Efectos Principales

The rate of large for gestational age was similar between groups (14.7% vs 15.1%; P = 0.839).

The composite serious health outcome for infants was reduced in the tighter group (1.3% vs 2.6%; P = 0.032).

Shorter length of stay in intensive care was observed in the tighter group (P = 0.041).

Serious maternal health outcomes increased in the tighter group (5.9% vs 3.0%; P = 0.020).

Resumen de Evidencia

InterventionOutcomeMeasured ChangeStudy Effect
Procedures
Less tight glycemic control
(Procedures)
Clinical Outcomes
Composite cardiovascular events (CV death, MI, stroke, HF hospitalization)
(Clinical Outcomes)
Decrease
Strong
Procedures
Less tight glycemic control
(Procedures)
Clinical Outcomes
Serious maternal health outcome
(Clinical Outcomes)
Increase
Unclear
Procedures
Less tight glycemic control
(Procedures)
Safety
Serious perinatal adverse events
(Safety)
No Change
Unclear
Procedures
Tighter glycemic control
(Procedures)
Clinical Outcomes
Composite cardiovascular events (CV death, MI, stroke, HF hospitalization)
(Clinical Outcomes)
Decrease
Strong
Procedures
Tighter glycemic control
(Procedures)
Clinical Outcomes
Serious maternal health outcome
(Clinical Outcomes)
Increase
Unclear
Procedures
Tighter glycemic control
(Procedures)
Safety
Serious perinatal adverse events
(Safety)
No Change
Unclear

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evidence suggest

La Evidencia Sugiere

  • Tighter glycaemic control reduced serious health outcomes for infants (1.3% vs 2.6%; P = 0.032).
  • Increased serious maternal health outcomes in the tighter group (5.9% vs 3.0%; P = 0.020).
  • More women required pharmacological treatment with tighter targets (67.9% vs 58.5%; P = 0.047).
who this applies

A quién se aplica

  • Women diagnosed with gestational diabetes.
  • Pregnant women requiring glycaemic management.
keep in mind

Tener en Cuenta

  • Results may not apply to all populations with gestational diabetes.
  • The study did not account for all potential confounding variables.
  • Further research is needed to explore long-term outcomes for mothers and infants.
between the lines

Entre Líneas

  • The study's design may limit generalizability to broader populations.
  • Potential confounding factors were not fully controlled.
  • The sample size may affect the robustness of the findings.

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Referencia de la Revista

Caroline AC, Deborah S, Ruth H, et al. Tighter Glycaemic Targets in Women with Gestational Diabetes: A Stepped-Wedge Cluster-Randomised Trial. PLOS Medicine. 2022;19(9):e1004087. doi:10.1371/journal.pmed.1004087

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Connected Evidence

Discover how this study fits into the broader diabetes evidence landscape.

This study contributes to evidence on Less tight glycemic control and Cardiovascular Outcomes, Tighter glycemic control and Cardiovascular Outcomes.

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Preguntas que esta evidencia ayuda a responder

Key clinical and research questions this study contributes to.

Does less tight glycemic control improve Composite cardiovascular events (CV death, MI, stroke, HF hospitalization)?

Based on connected evidence for Less tight glycemic control and Composite cardiovascular events (CV death, MI, stroke, HF hospitalization).

Does tighter glycemic control affect Composite cardiovascular events (CV death, MI, stroke, HF hospitalization) in people with diabetes?

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