Última actualización 14 de julio de 2026
Key finding
Total weight loss was -17.6 ± 6.0 kg for RYGB vs. -15.6 ± 5.1 kg for VLCD (p = 0.335).
This study compared the effectiveness of Roux-en-Y gastric bypass (RYGB) and a very low-calorie diet (VLCD) in individuals with obesity, finding no significant differences in weight loss outcomes.
Quick read
The essential study design details in one scan.
EvidenceScore™
Moderate
Study type
RCTs
Follow-up
Medium-Term (3–12 mo)
Risk of bias
Some Concerns
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Plain-language summary
A plain-language read of the study’s main message and where it applies.
Study focus
This study compared the effectiveness of Roux-en-Y gastric bypass (RYGB) and a very low-calorie diet (VLCD) in individuals with obesity, finding no significant differences in weight loss outcomes.
Understanding the comparative effectiveness of RYGB and VLCD is crucial for clinicians and patients when considering treatment options for obesity. The findings suggest that both interventions can lead to significant weight loss and health improvements, allowing for informed decision-making based on patient preferences and individual circumstances.
The study design was non-randomized, which may introduce bias. Sample size and demographic characteristics were not specified. Results may not be generalizable to all populations with obesity.
Published in
Publication details and source links for this paper.
Chanawit S, Prapimporn CS, Supphamat C, et al. A Very Low-Calorie Diet Compared with Roux-en-Y Gastric Bypass Surgery in Individuals with Obesity. Nutrients. 2024;16(15):2407. doi:10.3390/nu16152407
Total weight loss was -17.6 ± 6.0 kg for RYGB vs. -15.6 ± 5.1 kg for VLCD (p = 0.335).
Percentage weight loss was -16.2% ± 4.3% for RYGB vs. -14.1% ± 3.6% for VLCD (p = 0.147).
Changes in body composition and resolution of comorbidities were similar between groups at 12 weeks.
Evidence network
Understand where this research contributes within the broader evidence network.
This study contributes evidence to Gastric bypass, Very-low-calorie ketogenic diet and Change in body composition after 12 weeks of treatment, Percentage weight loss after 12 weeks, Resolution of comorbidities after 12 weeks, and 1 more.
This study contributes evidence to
Primary intervention
Gastric bypass
Primary outcomes
Intervention and outcome relationships this study adds to the evidence network.
Editorial context
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Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
4
Related topics
8
Evidence pairs
547
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Contributes evidence
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Contributes evidence
Evidence topic
Contributes evidence
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Contributes evidence
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Evidencia principal
Relación de evidencia
Evidencia relacionada
Relación de evidencia
Guardar evidencia
Relación de evidencia
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Core evidence
The primary outcomes reported in this study.
Gastric bypass → Change in body composition after 12 weeks of treatment
Gastric bypass → Change in body composition after 12 weeks of treatment
Gastric bypass → Percentage weight loss after 12 weeks
Gastric bypass → Percentage weight loss after 12 weeks
Gastric bypass → Resolution of comorbidities after 12 weeks
Gastric bypass → Resolution of comorbidities after 12 weeks
Gastric bypass → Total weight loss after 12 weeks
Gastric bypass → Total weight loss after 12 weeks
Very-low-calorie ketogenic diet → Change in body composition after 12 weeks of treatment
Very-low-calorie ketogenic diet → Change in body composition after 12 weeks of treatment
Very-low-calorie ketogenic diet → Percentage weight loss after 12 weeks
Very-low-calorie ketogenic diet → Percentage weight loss after 12 weeks
Very-low-calorie ketogenic diet → Resolution of comorbidities after 12 weeks
Very-low-calorie ketogenic diet → Resolution of comorbidities after 12 weeks
Very-low-calorie ketogenic diet → Total weight loss after 12 weeks
Very-low-calorie ketogenic diet → Total weight loss after 12 weeks
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Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on Ketogenic Diets and Weight Loss Outcomes, Bariatric Procedures and Body Composition.
This study contributes to the evidence on the following intervention-outcome relationships.
Diet and Nutrition
Procedures
Curated evidence collections and hubs this study is part of.
All studies on Ketogenic Diets
Contributes to Ketogenic Diets evidence base.
All studies measuring Weight Loss Outcomes
Measures Weight Loss Outcomes as a key outcome.
All studies on Bariatric Procedures
Contributes to Bariatric Procedures evidence base.
All studies measuring Body Composition
Measures Body Composition as a key outcome.
Latest published studies
Published within the last 2 years.
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2 results
1 results
2 results
1 results
2 results
Generated from the study's connected evidence using Evidence Intelligence™.
Ketogenic Diets may improve body composition.
ConsistencyScore™: Results are consistent across studies.
Ranked evidence signals
Change in body composition after 12 weeks of treatment
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | neutral | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on 6 supporting studies with consistent results and a positive effect signal.
Bariatric Procedures appear to affect weight loss outcomes.
ConsistencyScore™: Results are consistent across studies.
Ranked evidence signals
Percentage weight loss after 12 weeks
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | neutral | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on 4 supporting studies with consistent results and a positive effect signal.
Ketogenic Diets appear to affect weight loss outcomes.
ConsistencyScore™: Results are consistent across studies.
Ranked evidence signals
Percentage weight loss after 12 weeks
EvidenceScore™ Moderate | EvidenceScore™ 68.8 | moderate positive | ConsistencyScore™ Mixed | 1 study
Why this answer: This answer is based on 4 supporting studies with consistent results and a positive effect signal.
Current evidence does not show a clear benefit of Bariatric Procedures for body composition.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Change in body composition after 12 weeks of treatment
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | neutral | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
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