Boscia senegalensis extract (BSP), a natural SGLT1/2 inhibitor, may lower blood sugar and HbA1c in type 2 diabetes
Last updated May 4, 2026
Key finding
A 12-week study in 332 type 2 diabetes patients found that Boscisucrophage (BSP), a natural Boscia senegalensis seed extract, significantly lowered blood glucose and HbA1c when added to existing therapy.
This study tested Boscisucrophage (BSP), a supplement made from Boscia senegalensis seeds, in 332 people with type 2 diabetes who still had high blood sugar despite medication. After 12 weeks of taking 350 mg capsules three times daily, most patients had lower blood glucose and HbA1c, along with increased urine glucose excretion.
Quick read
Study at a glance
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EvidenceScore™
Moderate
Study type
non-randomized clinical trial (non-RCT or NRCT)
Follow-up
Short-Term (≤3 mo)
Risk of bias
High Risk
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Plain-language summary
What this paper says
A plain-language read of the study’s main message and where it applies.
Study focus
A 12-week study in 332 type 2 diabetes patients found that Boscisucrophage (BSP), a natural Boscia senegalensis seed extract, significantly lowered blood glucose and HbA1c when added to existing therapy.
Published in
Journal Reference
Publication details and source links for this paper.
Eto B, Elrherabi A, Nasr FA, et al. Boscisucrophage: A Natural SGLT1/2 Inhibitor From Boscia senegalensis for Managing Type 2 Diabetes. Food Sci Nutr. 2026;14(3):e71621.
Main Effects
↓ Blood glucose (significant reduction observed after 1 week of treatment)
↓ HbA1c (below 7% after 60 days of treatment)
↑ Urine glucose excretion via SGLT1/SGLT2 inhibition
Evidence Suggest
- BSP significantly reduced blood glucose and HbA1c in T2DM patients resistant to oral antihyperglycemic drugs
- Increased urine glucose excretion (UGE) suggests dual SGLT1/SGLT2 inhibition mechanism
- No significant adverse effects on liver or kidney function were observed
Who this applies to
People with type 2 diabetes who have difficulty controlling blood sugar with oral medications alone, particularly in regions where Boscia senegalensis is traditionally used as a food and medicine source.
Keep in Mind
This was a preliminary single-arm study without a control group, so the results may be influenced by other factors like increased attention or natural disease changes. Randomized controlled trials are needed before firm conclusions can be drawn about BSP's effectiveness compared to standard treatments.
Between the Lines
- Single-arm uncontrolled design limits attribution of effects to BSP alone
- No randomization or blinding introduces potential bias
- BMI was not systematically recorded at baseline, limiting weight-related analysis
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