Dapagliflozin plus gliclazide combination improves blood sugar control in type 2 diabetes
Key takeaway:
Combining dapagliflozin with gliclazide improves blood sugar control more than dapagliflozin alone in type 2 diabetes.
Study at a glance
What was studied
A trial of 244 Indian adults with type 2 diabetes testing combination therapy over 16 weeks
Study type
RCTs
duration
Short-Term (≤3 mo)
Intervention
Dapagliflozin Gliclazide combination, Dapagliflozin
Outcomes
HbA1c, Fasting Plasma Glucose, Postprandial glucose, Hypoglycemia events
Funding
Industry sponsored
Main effects
HbA1c → ↓ (moderate improvement, additional 0.3% reduction)
Fasting blood sugar → ↓ (moderate improvement)
After-meal blood sugar → ↓ (moderate improvement)
Evidence Summary
| Intervention | Outcome | Measured Change | Study Effect |
|---|---|---|---|
 Dapagliflozin (Medications) |  Fasting Plasma Glucose (Glycemic Control) | Decrease | Strong |
Dapagliflozin (Medications) | HbA1c (Glycemic Control) | Decrease | Strong |
Dapagliflozin (Medications) |  Hypoglycemia events (Safety) | Uncertain | Strong |
Dapagliflozin (Medications) | Postprandial glucose (Glycemic Control) | Decrease | Strong |
Dapagliflozin Gliclazide combination (Medications) | Fasting Plasma Glucose (Glycemic Control) | Decrease | Strong |
Dapagliflozin Gliclazide combination (Medications) | HbA1c (Glycemic Control) | Decrease | Strong |
Dapagliflozin Gliclazide combination (Medications) | Hypoglycemia events (Safety) | Increase | Limited |
Dapagliflozin Gliclazide combination (Medications) | Postprandial glucose (Glycemic Control) | Decrease | Strong |
Gliclazide SR (Medications) | Fasting Plasma Glucose (Glycemic Control) | Decrease | Strong |
Gliclazide SR (Medications) | HbA1c (Glycemic Control) | Decrease | Strong |
Gliclazide SR (Medications) | Hypoglycemia events (Safety) | Increase | Limited |
Gliclazide SR (Medications) | Postprandial glucose (Glycemic Control) | Decrease | Strong |
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Evidence Suggest
- The combination of dapagliflozin plus gliclazide appears to lower HbA1c more than dapagliflozin alone in people taking metformin
- Fasting and after-meal blood sugar levels also improved more with the combination
- Low blood sugar events were uncommon and not serious
Who this applies to
Adults aged 18-65 with type 2 diabetes whose blood sugar remains poorly controlled (HbA1c 8-10%) despite taking metformin at adequate doses for at least 3 months. Does not apply to people with reduced kidney function, type 1 diabetes, or very high blood sugar levels.
Keep in Mind
Study participants were from India only, so results may not fully apply to other populations
Between the Lines
- Short 16-week study period
- Open-label design (not blinded)
- Excluded people with kidney problems
- Conducted only in India
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Journal Reference
Erande SG, Raykantiwar A, Shejole V, et al. A Randomized, Multicenter Study Evaluating the Efficacy, Safety and Tolerability of Dapagliflozin + Gliclazide Fixed Dose Combination Over Dapagliflozin Monotherapy in Type 2 Diabetes Mellitus Patients Inadequately Controlled on Metformin Monotherapy. Cureus. 2026;18(2):e103676. doi:10.7759/cureus.103676
Connected Evidence
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This study contributes to evidence on Dapagliflozin and HbA1c.
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