Evidence Intelligence™
- EvidenceScore™
- 85
- Strong
- ImpactScore™
- 80
- Positive
- ConsistencyScore™
- 83
- consistent
Supporting studies: Based on 7 studies
Add to Evidence TrackerType 2 Diabetes (T2D)Supplements and Vitamins
Research Summary
Analyzed using Evidence Intelligence™
Pilot protocol compares Ayurvedic Nimba-Amalakyadi powder versus metformin for type 2 diabetes
Last updated May 26, 2026
Key finding
This article is a pilot trial protocol in adults with newly diagnosed type 2 diabetes that plans to compare Nimba-Amalakyadi powder against metformin over 45 days, with follow-up to day 90, and no final efficacy results are reported yet.
This publication describes a planned pilot randomized open-label trial, not completed efficacy outcomes. It proposes enrolling 36 participants with type 2 diabetes to compare Nimba-Amalakyadi powder versus metformin for 45 days, with day-90 follow-up. The protocol emphasizes feasibility metrics and exploratory glycemic trends, but final comparative results are not available in this article.
Quick read
Study at a glance
The essential study design details in one scan.
EvidenceScore™
Low
Study type
Randomized Controlled Trials (RCTs)
Follow-up
Short-Term (≤3 mo)
Risk of bias
Some Concerns
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Plain-language summary
What this paper says
A plain-language read of the study’s main message and where it applies.
Study focus
This article is a pilot trial protocol in adults with newly diagnosed type 2 diabetes that plans to compare Nimba-Amalakyadi powder against metformin over 45 days, with follow-up to day 90, and no final efficacy results are reported yet.
Published in
Journal Reference
Publication details and source links for this paper.
Sawarkar P, Sawarkar GR. Evaluation of the comparative efficacy of an Ayurvedic formulation (Nimba-Amalakyadi powder) vs metformin in the management of type 2 diabetes mellitus: protocol for a pilot study. JMIR Res Protoc. 2026;15:e63574. doi:10.2196/63574
Main Effects
No completed comparative efficacy results reported in this protocol publication
Planned glycemic endpoints include HbA1c, fasting blood sugar, postprandial glucose, and urine sugar
Feasibility endpoints include recruitment, retention, adherence, acceptability, and data completeness
Evidence network
How this study fits
Understand where this research contributes within the broader evidence network.
Evidence Context
This study contributes evidence to Metformin, Nimba-Amalakyadi powder and HbA1c, Urine sugar.
This study contributes evidence to
Primary intervention
Metformin
Primary outcomes
- HbA1c
- Urine sugar
Evidence topics
Primary intervention
Primary outcomes
Evidence relationships
Intervention and outcome relationships this study adds to the evidence network.
3
Evidence pairs
3
Relationships
2
Evidence topics
contributes_evidence
Editorial context
Why this study matters
See why this paper is useful beyond its individual results.
Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
Moderate contributionModerate confidenceNetwork score: 50
2
Related topics
3
Evidence pairs
222
Related studies
High relevance in at least one topic
Why it is useful
- Contributes to 3 evidence relationships
- Uses a randomized study design signal
- Linked to 2 direct semantic evidence topics
Topic contributions
Evidence topic
Contributes evidence
Evidence topic
Contributes evidence
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Primary evidence
Evidence relationship
Metformin Therapies and HbA1c
Related evidence
Evidence topic
HbA1c Reduction
Save evidence
Evidence topic
Metformin
Save evidence
Core evidence
Study findings
The primary outcomes reported in this study.
Evidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 55
- Slightly Positive
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence TrackerEvidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 55
- Slightly Positive
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence TrackerEvidence Library
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Evidence Suggest
- Methods section specifies randomized allocation with two groups and 45-day intervention exposure plus day-90 follow-up.
- The paper explicitly identifies itself as a protocol and states final results are expected after completion phases.
- Outcome variables are described as planned measurements rather than reported comparative endpoint results.
Who this applies to
Adults aged 20-60 years with newly diagnosed type 2 diabetes (<6 months)
Keep in Mind
Interpret this as a protocol, not a completed efficacy trial.
Between the Lines
- This publication is a protocol and does not report final efficacy results.
- Small planned pilot sample size (n=36) limits inferential strength.
- Open-label design may introduce performance and expectation biases.
- Single-center setting may limit generalizability.
Evidence Library
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Connected Evidence
Explore related studies, evidence collections, and research questions.
Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on Metformin Therapies and HbA1c, Nimba-Amalakyadi powder and HbA1c.
Related evidence relationships
Explore in Evidence ExplorerThis study contributes to the evidence on the following intervention-outcome relationships.
Medications
Metformin Therapies → HbA1c
Medications
Evidence Intelligence™
- EvidenceScore™
- 85
- Strong
- ImpactScore™
- 80
- Positive
- ConsistencyScore™
- 83
- consistent
Supporting studies: Based on 7 studies
View evidenceSupplements
Nimba-Amalakyadi powder → HbA1c
Supplements
Evidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 55
- Slightly Positive
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
View evidenceIncluded in these evidence collections
Curated evidence collections and hubs this study is part of.
HbA1c Evidence Hub
All studies measuring HbA1c
7 studies
outcome_hubMeasures HbA1c as a key outcome.
Metformin Therapies Evidence Hub
All studies on Metformin Therapies
7 studies
intervention_hubContributes to Metformin Therapies evidence base.
Nimba-Amalakyadi powder Evidence Hub
All studies on Nimba-Amalakyadi powder
1 studies
intervention_hubContributes to Nimba-Amalakyadi powder evidence base.
Explore more in Evidence Explorer
Jump to pre-filtered views in Evidence Explorer.
All studies on Metformin and HbA1c
Intervention: MetforminOutcome: HbA1c
7 results
All studies on Nimba-Amalakyadi powder and HbA1c
Intervention: Nimba-Amalakyadi powderOutcome: HbA1c
1 results
All studies on Metformin
Intervention: Metformin
7 results
All studies on Nimba-Amalakyadi powder
Intervention: Nimba-Amalakyadi powder
1 results
All studies measuring HbA1c
Outcome: HbA1c
7 results
Questions answered by this study
Generated from the study's connected evidence using Evidence Intelligence™.
Does Metformin Therapies improve HbA1c?
Strong Evidence
Metformin Therapies may improve HbA1c.
ConsistencyScore™: Results are consistent across studies.
Ranked evidence signals
- 1
HbA1c
EvidenceScore™ Strong | EvidenceScore™ 85.4 | moderate positive | ConsistencyScore™ Consistent | 1 study
Why this answer: This answer is based on 8 supporting studies with consistent results and a positive effect signal.
Limitations
- Population details are unavailable.
Does Nimba-Amalakyadi powder improve HbA1c?
Emerging Evidence
Nimba-Amalakyadi powder may improve HbA1c.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
- 1
HbA1c
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | weak positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
- Only one supporting study is available.
- Consistency cannot yet be determined.
- Population details are unavailable.
Does Nimba-Amalakyadi powder improve urine sugar?
Emerging Evidence
Nimba-Amalakyadi powder may improve Urine sugar.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
- 1
Urine sugar
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | weak positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
- Only one supporting study is available.
- Consistency cannot yet be determined.
- Population details are unavailable.
Next steps
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Evidence topics
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