Research Summary

Analyzed using Evidence Intelligence™

Antibiotics not needed for dental extractions in controlled type 2 diabetics

Last updated September 9, 2026

Key finding

The number of analgesics taken was higher in the amoxicillin group (p < 0.05).

This study evaluated the effectiveness of antibiotic prophylaxis using amoxicillin versus placebo in controlled type 2 diabetics undergoing dental extraction, finding no significant differences in most outcomes.

Quick read

Study at a glance

The essential study design details in one scan.

EvidenceScore™

Moderate

Study type

RCTs

Follow-up

Extended (5–20+ y)

Risk of bias

Some Concerns

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Plain-language summary

What this paper says

A plain-language read of the study’s main message and where it applies.

Study focus

Clinical relevance

These findings suggest that routine antibiotic prophylaxis with amoxicillin may not be necessary for controlled type 2 diabetics undergoing dental extractions, potentially reducing unnecessary antibiotic use and its associated risks. This could help inform clinical guidelines and improve patient safety.

Keep in mind

Small sample size may limit generalizability. Short follow-up period may not capture long-term outcomes. Lack of detailed baseline characteristics may affect comparability.

Published in

Journal Reference

Publication details and source links for this paper.

Matias G, Teresa N, Ariel FG, Federico S, Sebastian AP. Antibiotic prophylaxis for dental extraction in controlled type 2 diabetics: a randomized clinical trial. Acta Odontológica Latinoamericana. 2025;38(1):82-90. doi:10.54589/aol.38/1/82

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Main Effects

No significant difference in pain between amoxicillin and placebo groups.

No significant difference in trismus or edema between groups.

Higher number of analgesics taken in the amoxicillin group (p < 0.05).

Evidence network

How this study fits

Understand where this research contributes within the broader evidence network.

Evidence Context

This study contributes evidence to Amoxicillin and Alveolar osteitis, Analgesics taken, Delayed healing, and 6 more.

This study contributes evidence to

Intervention

Amoxicillin

Outcome

Alveolar osteitis

Primary intervention

Amoxicillin

Primary outcomes

Alveolar osteitis
Analgesics taken
Delayed healing

Primary intervention

Amoxicillin

Primary outcomes

Alveolar osteitis Analgesics taken Delayed healing

Evidence relationships

Intervention and outcome relationships this study adds to the evidence network.

Evidence pairs

Relationships

Evidence topics

contributes_evidence

Editorial context

Why this study matters

See why this paper is useful beyond its individual results.

Evidence network role

This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.

Moderate contributionModerate confidenceNetwork score: 54

Why it is useful

Contributes to 9 evidence relationships
Includes primary outcome data
Linked to 0 direct semantic evidence topics

Core evidence

Study findings

The primary outcomes reported in this study.

Alveolar osteitis

Amoxicillin → Alveolar osteitis

Evidence Intelligence™

EvidenceScore™: Emerging; Score 59 · Based on 1 study
ImpactScore™: 50; Neutral
ConsistencyScore™: unclear; Not enough independent studies

Based on 1 study

Add to Evidence Tracker

Analgesics taken

Amoxicillin → Analgesics taken

Evidence Intelligence™

EvidenceScore™: Emerging; Score 59 · Based on 1 study
ImpactScore™: 100; Very Positive
ConsistencyScore™: unclear; Not enough independent studies

Based on 1 study

Add to Evidence Tracker

Delayed healing

Amoxicillin → Delayed healing

Evidence Intelligence™

EvidenceScore™: Emerging; Score 59 · Based on 1 study
ImpactScore™: 50; Neutral
ConsistencyScore™: unclear; Not enough independent studies

Based on 1 study

Add to Evidence Tracker

Gastric alterations

Amoxicillin → Gastric alterations

Evidence Intelligence™

EvidenceScore™: Emerging; Score 59 · Based on 1 study
ImpactScore™: 50; Neutral
ConsistencyScore™: unclear; Not enough independent studies

Based on 1 study

Add to Evidence Tracker

Hemorrhage

Amoxicillin → Hemorrhage

Evidence Intelligence™

EvidenceScore™: Emerging; Score 59 · Based on 1 study
ImpactScore™: 50; Neutral
ConsistencyScore™: unclear; Not enough independent studies

Based on 1 study

Add to Evidence Tracker

Incidence of edema during follow-up

Amoxicillin → Incidence of edema during follow-up

Evidence Intelligence™

EvidenceScore™: Emerging; Score 59 · Based on 1 study
ImpactScore™: 50; Neutral
ConsistencyScore™: unclear; Not enough independent studies

Based on 1 study

Add to Evidence Tracker

Incidence of new or recurrent infections

Amoxicillin → Incidence of new or recurrent infections

Evidence Intelligence™

EvidenceScore™: Emerging; Score 59 · Based on 1 study
ImpactScore™: 50; Neutral
ConsistencyScore™: unclear; Not enough independent studies

Based on 1 study

Add to Evidence Tracker

Pain

Amoxicillin → Pain

Evidence Intelligence™

EvidenceScore™: Emerging; Score 59 · Based on 1 study
ImpactScore™: 50; Neutral
ConsistencyScore™: unclear; Not enough independent studies

Based on 1 study

Add to Evidence Tracker

Trismus

Amoxicillin → Trismus

Evidence Intelligence™

EvidenceScore™: Emerging; Score 59 · Based on 1 study
ImpactScore™: 50; Neutral
ConsistencyScore™: unclear; Not enough independent studies

Based on 1 study

Add to Evidence Tracker

Evidence Library

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Evidence Suggest

No cases of alveolar osteitis were recorded in either group.
No local or systemic infections were reported in either group.
Amoxicillin group required more analgesics, indicating higher pain management needs.

Who this applies to

Adults with controlled type 2 diabetes undergoing dental extractions.
Patients receiving dental care in outpatient settings.

Keep in Mind

Results may not apply to uncontrolled diabetics or other populations.
Findings are specific to dental extractions and may not generalize to other procedures.
Further research is needed to explore long-term effects and different antibiotic regimens.

Between the Lines

Small sample size may limit generalizability.
Short follow-up period may not capture long-term outcomes.
Lack of detailed baseline characteristics may affect comparability.

Evidence Library

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Connected Evidence

Explore related studies, evidence collections, and research questions.

Relationships organized using the Dediabetes Evidence Intelligence™ framework.

This study contributes to evidence on Amoxicillin and Alveolar osteitis, Amoxicillin and Analgesics taken.

Related evidence relationships

Explore in Evidence Explorer

This study contributes to the evidence on the following intervention-outcome relationships.

Medications

Detailed evidence

Amoxicillin → Alveolar osteitis

Medications

Evidence Intelligence™

EvidenceScore™: Emerging; Score 59 · Based on 1 study
ImpactScore™: 50; Neutral
ConsistencyScore™: unclear; Not enough independent studies

Based on 1 study

View evidence

Medications

Detailed evidence

Amoxicillin → Analgesics taken

Medications

Evidence Intelligence™

EvidenceScore™: Emerging; Score 59 · Based on 1 study
ImpactScore™: 100; Very Positive
ConsistencyScore™: unclear; Not enough independent studies

Based on 1 study

View evidence

Included in these evidence collections

Curated evidence collections and hubs this study is part of.

Alveolar osteitis Evidence Hub

All studies measuring Alveolar osteitis

1 studies

outcome_hub

Measures Alveolar osteitis as a key outcome.

Amoxicillin Evidence Hub

All studies on Amoxicillin

1 studies

intervention_hub

Contributes to Amoxicillin evidence base.

Analgesics taken Evidence Hub

All studies measuring Analgesics taken

1 studies

outcome_hub

Measures Analgesics taken as a key outcome.

Recent Diabetes Research

Latest published studies

recency_collection

Published within the last 2 years.

Explore more in Evidence Explorer

Jump to pre-filtered views in Evidence Explorer.

All studies on Amoxicillin and Alveolar osteitis

Intervention: AmoxicillinOutcome: Alveolar osteitis

1 results

All studies on Amoxicillin and Analgesics taken

Intervention: AmoxicillinOutcome: Analgesics taken

1 results

All studies on Amoxicillin

Intervention: Amoxicillin

1 results

All studies measuring Alveolar osteitis

Outcome: Alveolar osteitis

1 results

All studies measuring Analgesics taken

Outcome: Analgesics taken

1 results

Questions answered by this study

Generated from the study's connected evidence using Evidence Intelligence™.

Does Amoxicillin improve analgesics taken?

Emerging Evidence

Amoxicillin appears to improve analgesics taken.

ConsistencyScore™: Consistency cannot yet be determined from the available evidence.

Ranked evidence signals

1
Analgesics taken
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study

Why this answer: This answer is based on a single supporting study.

Limitations

Only one supporting study is available.

View Full Evidence

Does Amoxicillin improve alveolar osteitis?

Emerging Evidence

Current evidence does not show a clear benefit of Amoxicillin for alveolar osteitis.

ConsistencyScore™: Consistency cannot yet be determined from the available evidence.

Ranked evidence signals

1
Alveolar osteitis
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | neutral | ConsistencyScore™ Unclear | 1 study

Why this answer: This answer is based on a single supporting study.

Limitations

Only one supporting study is available.

View Full Evidence

Does Amoxicillin improve delayed healing?

Emerging Evidence

Current evidence does not show a clear benefit of Amoxicillin for delayed healing.

ConsistencyScore™: Consistency cannot yet be determined from the available evidence.

Ranked evidence signals

1
Delayed healing
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | neutral | ConsistencyScore™ Unclear | 1 study

Why this answer: This answer is based on a single supporting study.

Limitations

Only one supporting study is available.

View Full Evidence

Does Amoxicillin improve gastric alterations?

Emerging Evidence

Current evidence does not show a clear benefit of Amoxicillin for gastric alterations.

ConsistencyScore™: Consistency cannot yet be determined from the available evidence.

Ranked evidence signals

1
Gastric alterations
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | neutral | ConsistencyScore™ Unclear | 1 study

Why this answer: This answer is based on a single supporting study.

Limitations

Only one supporting study is available.

View Full Evidence

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Next steps

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Explore in Evidence Explorer

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All studies on Amoxicillin and Alveolar osteitis All studies on Amoxicillin and Analgesics taken All studies on Amoxicillin and Delayed healing All studies on Amoxicillin and Gastric alterations

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