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Research Summary
Analyzed using Evidence Intelligence™

Aspirin and Omega-3s Show Little Effect on AMD

Powered by the Dediabetes Evidence Intelligence™ framework

Last updated September 3, 2026

Key finding

Rate ratio 0.88; 95% CI 0.69 to 1.12; p=0.31

This study investigated the efficacy and safety of aspirin and omega-3 fatty acids on age-related macular degeneration (AMD). The findings indicated no significant difference in AMD incidence between treatment and placebo groups.

Quick read

Study at a glance

The essential study design details in one scan.

EvidenceScore™

Moderate

Study type

RCTs

Follow-up

Long-Term (1–5 y)

Risk of bias

Some Concerns

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Plain-language summary

What this paper says

A plain-language read of the study’s main message and where it applies.

Study focus

This study investigated the efficacy and safety of aspirin and omega-3 fatty acids on age-related macular degeneration (AMD). The findings indicated no significant difference in AMD incidence between treatment and placebo groups.

Clinical relevance

Understanding the effectiveness of common treatments like aspirin and omega-3 fatty acids for preventing AMD is crucial, as AMD is a leading cause of vision loss. These findings suggest that these interventions may not provide the hoped-for benefits in preventing this condition.

Keep in mind

The study did not find statistically significant differences in AMD incidence. The sample size may limit the generalizability of the findings. Potential confounding factors were not fully explored.

Published in

Journal Reference

Publication details and source links for this paper.

Emily S, Louise B, William S, et al. Randomised evidence for the efficacy and safety of aspirin and omega-3 FAs on AMD. BMJ Open. 2025;15(2):e090605. doi:10.1136/bmjopen-2024-090605

View DOIView on PubMedView on PMC

Main Effects

Aspirin group had 122 (1.6%) cases of AMD compared to 138 (1.8%) in placebo (rate ratio 0.88, p=0.31).

Omega-3 fatty acids group had 130 (1.7%) cases of AMD compared to 130 (1.7%) in placebo (rate ratio 0.99, p=0.99).

Evidence network

How this study fits

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Evidence Context

This study contributes evidence to 1 g omega-3 fatty acids daily, 100 mg aspirin daily and Incidence of age-related macular degeneration (AMD) for omega-3 fatty acids, Mean difference in post-meal glucose surges.

This study contributes evidence to

Intervention

1 g omega-3 fatty acids daily

Outcome

Incidence of age-related macular degeneration (AMD) for omega-3 fatty acids

Primary intervention

1 g omega-3 fatty acids daily

Primary outcomes

  • Incidence of age-related macular degeneration (AMD) for omega-3 fatty acids
  • Mean difference in post-meal glucose surges

Primary intervention

1 g omega-3 fatty acids daily

Primary outcomes

Incidence of age-related macular degeneration (AMD) for omega-3 fatty acidsMean difference in post-meal glucose surges

Evidence relationships

Intervention and outcome relationships this study adds to the evidence network.

2
Evidence pairs
2
Relationships
0
Evidence topics
contributes_evidence

Editorial context

Why this study matters

See why this paper is useful beyond its individual results.

Evidence network role

This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.

Moderate contributionModerate confidenceNetwork score: 46

0

Related topics

2

Evidence pairs

0

Related studies

Why it is useful

  • Contributes to 2 evidence relationships
  • Includes primary outcome data
  • Linked to 0 direct semantic evidence topics

Core evidence

Study findings

The primary outcomes reported in this study.

Incidence of age-related macular degeneration (AMD) for omega-3 fatty acids

1 g omega-3 fatty acids daily → Incidence of age-related macular degeneration (AMD) for omega-3 fatty acids

1 g omega-3 fatty acids daily → Incidence of age-related macular degeneration (AMD) for omega-3 fatty acids

Evidence Intelligence™
EvidenceScore™
Emerging
Score 59 · Based on 1 study
ImpactScore™
50
Neutral
ConsistencyScore™
unclear
Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence Tracker

Mean difference in post-meal glucose surges

100 mg aspirin daily → Mean difference in post-meal glucose surges

100 mg aspirin daily → Mean difference in post-meal glucose surges

Evidence Intelligence™
EvidenceScore™
Emerging
Score 59 · Based on 1 study
ImpactScore™
50
Neutral
ConsistencyScore™
unclear
Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence Tracker

Evidence Library

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evidence suggest

Evidence Suggest

  • Aspirin did not significantly reduce AMD incidence (rate ratio 0.88, p=0.31).
  • Omega-3 fatty acids also showed no significant effect on AMD (rate ratio 0.99, p=0.99).
who this applies

Who this applies to

  • Adults at risk for age-related macular degeneration.
  • Individuals considering aspirin or omega-3 fatty acids for eye health.
keep in mind

Keep in Mind

  • Results may not apply to populations outside the study sample.
  • The lack of significant findings does not rule out potential benefits in other contexts.
  • Further research is needed to explore other potential treatments for AMD.
between the lines

Between the Lines

  • The study did not find statistically significant differences in AMD incidence.
  • The sample size may limit the generalizability of the findings.
  • Potential confounding factors were not fully explored.

Evidence Library

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Connected Evidence

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Relationships organized using the Dediabetes Evidence Intelligence™ framework.

Powered by the Dediabetes Evidence Intelligence™ framework

This study contributes to evidence on 1 g omega-3 fatty acids daily and Incidence of age-related macular degeneration (AMD) for omega-3 fatty acids, 100 mg aspirin daily and Mean difference in post-meal glucose surges.

Related evidence relationships

Explore in Evidence Explorer

This study contributes to the evidence on the following intervention-outcome relationships.

Included in these evidence collections

Curated evidence collections and hubs this study is part of.

1 g omega-3 fatty acids daily Evidence Hub

All studies on 1 g omega-3 fatty acids daily

1 studies
intervention_hub

Contributes to 1 g omega-3 fatty acids daily evidence base.

100 mg aspirin daily Evidence Hub

All studies on 100 mg aspirin daily

1 studies
intervention_hub

Contributes to 100 mg aspirin daily evidence base.

Incidence of age-related macular degeneration (AMD) for omega-3 fatty acids Evidence Hub

All studies measuring Incidence of age-related macular degeneration (AMD) for omega-3 fatty acids

1 studies
outcome_hub

Measures Incidence of age-related macular degeneration (AMD) for omega-3 fatty acids as a key outcome.

Mean difference in post-meal glucose surges Evidence Hub

All studies measuring Mean difference in post-meal glucose surges

1 studies
outcome_hub

Measures Mean difference in post-meal glucose surges as a key outcome.

Recent Diabetes Research

Latest published studies

recency_collection

Published within the last 2 years.

Explore more in Evidence Explorer

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All studies on 1 g omega-3 fatty acids daily and Incidence of age-related macular degeneration (AMD) for omega-3 fatty acids

Intervention: 1 g omega-3 fatty acids dailyOutcome: Incidence of age-related macular degeneration (AMD) for omega-3 fatty acids

1 results

All studies on 100 mg aspirin daily and Mean difference in post-meal glucose surges

Intervention: 100 mg aspirin dailyOutcome: Mean difference in post-meal glucose surges

1 results

All studies on 1 g omega-3 fatty acids daily

Intervention: 1 g omega-3 fatty acids daily

1 results

All studies on 100 mg aspirin daily

Intervention: 100 mg aspirin daily

1 results

All studies measuring Incidence of age-related macular degeneration (AMD) for omega-3 fatty acids

Outcome: Incidence of age-related macular degeneration (AMD) for omega-3 fatty acids

1 results

Questions answered by this study

Generated from the study's connected evidence using Evidence Intelligence™.

Does 1 g omega-3 fatty acids daily reduce incidence of age-related macular degeneration (AMD) for omega-3 fatty acids?

Emerging Evidence

Current evidence does not show a clear reduction in incidence of age-related macular degeneration (AMD) for omega-3 fatty acids with 1 g omega-3 fatty acids daily.

ConsistencyScore™: Consistency cannot yet be determined from the available evidence.

Ranked evidence signals

  1. 1

    Incidence of age-related macular degeneration (AMD) for omega-3 fatty acids

    EvidenceScore™ Emerging | EvidenceScore™ 59.0 | neutral | ConsistencyScore™ Unclear | 1 study

Why this answer: This answer is based on a single supporting study.

Limitations

  • Only one supporting study is available.
1 supporting study
View Full Evidence

Does 100 mg aspirin daily improve mean difference in post-meal glucose surges?

Emerging Evidence

Current evidence does not show a clear benefit of 100 mg aspirin daily for mean difference in post-meal glucose surges.

ConsistencyScore™: Consistency cannot yet be determined from the available evidence.

Ranked evidence signals

  1. 1

    Mean difference in post-meal glucose surges

    EvidenceScore™ Emerging | EvidenceScore™ 59.0 | neutral | ConsistencyScore™ Unclear | 1 study

Why this answer: This answer is based on a single supporting study.

Limitations

  • Only one supporting study is available.
1 supporting study
View Full Evidence
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All studies on 1 g omega-3 fatty acids daily and Incidence of age-related macular degeneration (AMD) for omega-3 fatty acidsAll studies on 100 mg aspirin daily and Mean difference in post-meal glucose surges

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