Last updated September 1, 2026
Key finding
Subjects taking WFBSK meal showed significant improvement in the cognitive domain of language memory after 12 weeks (p < 0.05).
This study investigated the effects of biofunctional boiled rice on cognitive function and insulin levels in adults with Type 2 diabetes, finding significant improvements in language memory.
Quick read
The essential study design details in one scan.
EvidenceScore™
Moderate
Study type
RCTs
Follow-up
Medium-Term (3–12 mo)
Risk of bias
Some Concerns
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Plain-language summary
A plain-language read of the study’s main message and where it applies.
Study focus
This study investigated the effects of biofunctional boiled rice on cognitive function and insulin levels in adults with Type 2 diabetes, finding significant improvements in language memory.
These findings suggest that incorporating biofunctional boiled rice into the diet may offer cognitive benefits and help manage insulin levels in adults with Type 2 diabetes. This could lead to improved dietary recommendations for this population, potentially enhancing both cognitive health and metabolic control.
Unclear effectiveness for some outcomes due to lack of significant findings. Limited generalizability as the study focused on a specific population. Potential confounding factors not measured.
Published in
Publication details and source links for this paper.
Sumiko N, Takeshi I, Aki A, et al. Biofunctional Boiled Rice Improves Cognitive Function and Lowers Insulin Levels in Adults with Type 2 Diabetes. Foods. 2022;11(6):818. doi:10.3390/foods11060818
Subjects taking WFBSK meal showed significant improvement in language memory after 12 weeks (p < 0.05).
Subjects consuming WFBSK had lower insulin secretion levels than those on control rice (p < 0.05).
No significant difference in plasma Aβ42/40 ratio between WFBSK and control meal.
Postprandial blood glucose levels showed no significant difference between WFBSK and control groups.
Evidence network
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This study contributes evidence to Biofunctional boiled rice (WFBSK) and Amyloid-β 42/40 ratio, Glucose iAUC (OGTT), Insulin secretion levels after Roux-en-Y gastric bypass surgery, and 1 more.
This study contributes evidence to
Primary intervention
Biofunctional boiled rice (WFBSK)
Primary outcomes
Evidence topics
Primary intervention
Intervention and outcome relationships this study adds to the evidence network.
Editorial context
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Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
2
Related topics
4
Evidence pairs
661
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Contributes evidence
Evidence topic
Contributes evidence
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Primary evidence
Evidence topic
matched_outcome
Related evidence
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Core evidence
The primary outcomes reported in this study.
Biofunctional boiled rice (WFBSK) → Amyloid-β 42/40 ratio
Biofunctional boiled rice (WFBSK) → Amyloid-β 42/40 ratio
Biofunctional boiled rice (WFBSK) → Glucose iAUC (OGTT)
Biofunctional boiled rice (WFBSK) → Glucose iAUC (OGTT)
Biofunctional boiled rice (WFBSK) → Insulin secretion levels after Roux-en-Y gastric bypass surgery
Biofunctional boiled rice (WFBSK) → Insulin secretion levels after Roux-en-Y gastric bypass surgery
Biofunctional boiled rice (WFBSK) → Significant improvement in language memory
Biofunctional boiled rice (WFBSK) → Significant improvement in language memory
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Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on Biofunctional boiled rice (WFBSK) and Neurodegeneration Biomarkers, Biofunctional boiled rice (WFBSK) and Postprandial and OGTT Glucose.
This study contributes to the evidence on the following intervention-outcome relationships.
Diet and Nutrition
Diet and Nutrition
Curated evidence collections and hubs this study is part of.
All studies on Biofunctional boiled rice (WFBSK)
Contributes to Biofunctional boiled rice (WFBSK) evidence base.
All studies measuring Neurodegeneration Biomarkers
Measures Neurodegeneration Biomarkers as a key outcome.
All studies measuring Postprandial and OGTT Glucose
Measures Postprandial and OGTT Glucose as a key outcome.
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1 results
1 results
1 results
1 results
1 results
Generated from the study's connected evidence using Evidence Intelligence™.
Biofunctional boiled rice (WFBSK) appears to improve significant improvement in language memory.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Significant improvement in language memory
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Current evidence does not show a clear benefit of Biofunctional boiled rice (WFBSK) for amyloid-β 42/40 ratio.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Amyloid-β 42/40 ratio
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | neutral | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Current evidence does not show a clear benefit of Biofunctional boiled rice (WFBSK) for glucose iauc (OGTT).
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Glucose iAUC (OGTT)
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | neutral | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Biofunctional boiled rice (WFBSK) may worsen insulin secretion levels after roux-en-y gastric bypass surgery or be associated with harm.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Insulin secretion levels after Roux-en-Y gastric bypass surgery
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | moderate negative | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
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