Last updated August 21, 2026
Key finding
No significant change in AUC for blood glucose levels above 3.9 was observed.
The New Zealand SYNERGY Study investigated the effects of two diet-controlled interventions on various health outcomes, finding no significant changes in key metrics.
Quick read
The essential study design details in one scan.
EvidenceScore™
Moderate
Study type
RCTs
Follow-up
Short-Term (≤3 mo)
Risk of bias
Some Concerns
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Plain-language summary
A plain-language read of the study’s main message and where it applies.
Study focus
The New Zealand SYNERGY Study investigated the effects of two diet-controlled interventions on various health outcomes, finding no significant changes in key metrics.
Understanding the effectiveness of dietary interventions is crucial for managing health, especially for conditions like diabetes. This study highlights the need for further research to identify effective dietary strategies that can lead to meaningful health improvements.
Limited sample size may affect generalizability. Short duration of the study might not capture long-term effects. Lack of significant findings raises questions about intervention effectiveness.
Published in
Publication details and source links for this paper.
Ivana RS, Karl F, Kok HL, et al. The New Zealand SYNERGY Study: A Fully Diet-Controlled Intervention Trial. Frontiers in Nutrition. 2025;12:1590579. doi:10.3389/fnut.2025.1590579
No significant change in AUC for blood glucose levels above 3.9.
No significant increase in GLP-1 RA dose among participants.
No significant resolution of metabolic dysfunction associated with steatohepatitis.
Evidence network
Understand where this research contributes within the broader evidence network.
This study contributes evidence to Best Practice Healthy Diet (BPHD) and 2-hour plasma glucose, Area under the curve (AUC) for blood glucose levels above 3.9, Change in Metabolic Dysfunction-Associated Fibrosis-5 (MAF-5), and 15 more.
This study contributes evidence to
Primary intervention
Best Practice Healthy Diet (BPHD)
Primary outcomes
Evidence topics
Primary intervention
Intervention and outcome relationships this study adds to the evidence network.
Editorial context
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Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
1
Related topics
18
Evidence pairs
346
Related studies
Evidence topic
Contributes evidence
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Primary evidence
Evidence topic
matched_outcome
Core evidence
The primary outcomes reported in this study.
Best Practice Healthy Diet (BPHD) → 2-hour plasma glucose
Best Practice Healthy Diet (BPHD) → 2-hour plasma glucose
Best Practice Healthy Diet (BPHD) → Area under the curve (AUC) for blood glucose levels above 3.9
Best Practice Healthy Diet (BPHD) → Area under the curve (AUC) for blood glucose levels above 3.9
Best Practice Healthy Diet (BPHD) → Change in Metabolic Dysfunction-Associated Fibrosis-5 (MAF-5)
Best Practice Healthy Diet (BPHD) → Change in Metabolic Dysfunction-Associated Fibrosis-5 (MAF-5)
Best Practice Healthy Diet (BPHD) → Difference in Thai-CV risk score at 12 months compared to routine care
Best Practice Healthy Diet (BPHD) → Difference in Thai-CV risk score at 12 months compared to routine care
Best Practice Healthy Diet (BPHD) → Glucose iAUC (OGTT)
Best Practice Healthy Diet (BPHD) → Glucose iAUC (OGTT)
Best Practice Healthy Diet (BPHD) → Glycemia risk index
Best Practice Healthy Diet (BPHD) → Glycemia risk index
Best Practice Healthy Diet (BPHD) → Increase in lipoperoxidation levels in T2D patients after M-meal compared to V-meal
Best Practice Healthy Diet (BPHD) → Increase in lipoperoxidation levels in T2D patients after M-meal compared to V-meal
Best Practice Healthy Diet (BPHD) → Median increase in carbohydrate ratios by day 77
Best Practice Healthy Diet (BPHD) → Median increase in carbohydrate ratios by day 77
Best Practice Healthy Diet (BPHD) → Median increase in correction factors by day 77
Best Practice Healthy Diet (BPHD) → Median increase in correction factors by day 77
Best Practice Healthy Diet (BPHD) → Percentage of patients with GLP-1 RA dose increased by at least one level
Best Practice Healthy Diet (BPHD) → Percentage of patients with GLP-1 RA dose increased by at least one level
Best Practice Healthy Diet (BPHD) → Plasma antioxidant capacity (FRAP)
Best Practice Healthy Diet (BPHD) → Plasma antioxidant capacity (FRAP)
Best Practice Healthy Diet (BPHD) → Plasma cholic secondary bile acids
Best Practice Healthy Diet (BPHD) → Plasma cholic secondary bile acids
Best Practice Healthy Diet (BPHD) → Plasma Electrolytes
Best Practice Healthy Diet (BPHD) → Plasma Electrolytes
Best Practice Healthy Diet (BPHD) → Plasma lipidome changes
Best Practice Healthy Diet (BPHD) → Plasma lipidome changes
Best Practice Healthy Diet (BPHD) → Relative risk reduction for major renal events
Best Practice Healthy Diet (BPHD) → Relative risk reduction for major renal events
Best Practice Healthy Diet (BPHD) → Resolution of metabolic dysfunction associated steatohepatitis
Best Practice Healthy Diet (BPHD) → Resolution of metabolic dysfunction associated steatohepatitis
Best Practice Healthy Diet (BPHD) → Risk of Obstructive Sleep Apnoea (OSA)
Best Practice Healthy Diet (BPHD) → Risk of Obstructive Sleep Apnoea (OSA)
Best Practice Healthy Diet (BPHD) → Urinary albumin-to-creatinine ratio
Best Practice Healthy Diet (BPHD) → Urinary albumin-to-creatinine ratio
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Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on Best Practice Healthy Diet (BPHD) and Postprandial and OGTT Glucose, Best Practice Healthy Diet (BPHD) and Area under the curve (AUC) for blood glucose levels above 3.9.
This study contributes to the evidence on the following intervention-outcome relationships.
Diet and Nutrition
Diet and Nutrition
Diet and Nutrition
Curated evidence collections and hubs this study is part of.
All studies measuring Area under the curve (AUC) for blood glucose levels above 3.9
Measures Area under the curve (AUC) for blood glucose levels above 3.9 as a key outcome.
All studies on Best Practice Healthy Diet (BPHD)
Contributes to Best Practice Healthy Diet (BPHD) evidence base.
All studies measuring Plasma lipidome changes
Measures Plasma lipidome changes as a key outcome.
All studies measuring Postprandial and OGTT Glucose
Measures Postprandial and OGTT Glucose as a key outcome.
Latest published studies
Published within the last 2 years.
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1 results
1 results
1 results
1 results
1 results
Generated from the study's connected evidence using Evidence Intelligence™.
Current evidence does not show a clear benefit of Best Practice Healthy Diet (BPHD) for 2-hour plasma glucose.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
2-hour plasma glucose
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | neutral | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Current evidence does not show a clear benefit of Best Practice Healthy Diet (BPHD) for Area under the curve (AUC) for blood glucose levels above 3.9.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Area under the curve (AUC) for blood glucose levels above 3.9
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | neutral | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Current evidence does not show a clear benefit of Best Practice Healthy Diet (BPHD) for Change in Metabolic Dysfunction-Associated Fibrosis-5 (MAF-5).
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Change in Metabolic Dysfunction-Associated Fibrosis-5 (MAF-5)
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | neutral | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Current evidence does not show a clear benefit of Best Practice Healthy Diet (BPHD) for Difference in Thai-CV risk score at 12 months compared to routine care.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Difference in Thai-CV risk score at 12 months compared to routine care
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | neutral | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
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