Last updated July 8, 2026
Key finding
Hazard ratio (95% CI) 0.84 (0.74–0.95)
The Finerenone Trial investigated the efficacy and safety of finerenone compared to placebo in patients with heart failure, demonstrating significant benefits.
Quick read
The essential study design details in one scan.
EvidenceScore™
Moderate
Study type
RCTs
Follow-up
Short-Term (≤3 mo)
Risk of bias
High Risk
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Plain-language summary
A plain-language read of the study’s main message and where it applies.
Study focus
The Finerenone Trial investigated the efficacy and safety of finerenone compared to placebo in patients with heart failure, demonstrating significant benefits.
These findings are clinically significant as they suggest that finerenone may provide an effective treatment option for patients with heart failure, potentially improving their quality of life and reducing hospitalizations, which are critical concerns in managing this condition.
Effectiveness of finerenone remains unclear due to unspecified evidence data. The study's population characteristics may limit generalizability. The trial did not include long-term follow-up data.
Published in
Publication details and source links for this paper.
Panagiotis IG, Christodoula K, Ioannis K, et al. Finerenone Trial to Investigate Efficacy and Safety Superior to Placebo in Patients with Heart Failure. American Journal of Cardiovascular Drugs. 2025;25(4):427-432. doi:10.1007/s40256-025-00723-2
Finerenone was superior to placebo in improving the primary composite outcome of worsening heart failure events.
Finerenone showed a significant reduction in hospitalization for heart failure compared to placebo.
Finerenone improved outcomes related to death from cardiovascular causes compared to placebo.
Evidence network
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This study contributes evidence to Finerenone (nonsteroidal mineralocorticoid receptor antagonist) and Cardiovascular death, Hospitalization for heart failure, Total worsening heart failure events and death from cardiovascular causes.
This study contributes evidence to
Primary intervention
Finerenone (nonsteroidal mineralocorticoid receptor antagonist)
Primary outcomes
Intervention and outcome relationships this study adds to the evidence network.
Editorial context
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Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
1
Related topics
3
Evidence pairs
45
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Evidence topic
Contributes evidence
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Primary evidence
Evidence topic
matched_outcome
Core evidence
The primary outcomes reported in this study.
Finerenone (nonsteroidal mineralocorticoid receptor antagonist) → Cardiovascular death
Finerenone (nonsteroidal mineralocorticoid receptor antagonist) → Cardiovascular death
Finerenone (nonsteroidal mineralocorticoid receptor antagonist) → Hospitalization for heart failure
Finerenone (nonsteroidal mineralocorticoid receptor antagonist) → Hospitalization for heart failure
Finerenone (nonsteroidal mineralocorticoid receptor antagonist) → Total worsening heart failure events and death from cardiovascular causes
Finerenone (nonsteroidal mineralocorticoid receptor antagonist) → Total worsening heart failure events and death from cardiovascular causes
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Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on Finerenone (nonsteroidal mineralocorticoid receptor antagonist) and Cardiovascular Outcomes, Finerenone (nonsteroidal mineralocorticoid receptor antagonist) and Cardiovascular Outcomes.
This study contributes to the evidence on the following intervention-outcome relationships.
Medications
Medications
Curated evidence collections and hubs this study is part of.
All studies measuring Cardiovascular Outcomes
Measures Cardiovascular Outcomes as a key outcome.
All studies on Finerenone (nonsteroidal mineralocorticoid receptor antagonist)
Contributes to Finerenone (nonsteroidal mineralocorticoid receptor antagonist) evidence base.
Latest published studies
Published within the last 2 years.
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2 results
1 results
2 results
2 results
1 results
Generated from the study's connected evidence using Evidence Intelligence™.
Finerenone (nonsteroidal mineralocorticoid receptor antagonist) appears to improve Hospitalization for heart failure.
ConsistencyScore™: Results are consistent across studies.
Ranked evidence signals
Hospitalization for heart failure
EvidenceScore™ Moderate | EvidenceScore™ 69.0 | strong positive | ConsistencyScore™ Consistent | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Finerenone (nonsteroidal mineralocorticoid receptor antagonist) appears to improve Cardiovascular death.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Cardiovascular death
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Finerenone (nonsteroidal mineralocorticoid receptor antagonist) appears to improve Total worsening heart failure events and death from cardiovascular causes.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Total worsening heart failure events and death from cardiovascular causes
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
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