Last updated September 2, 2026
Key finding
Mean daily energy intake was reduced by 27% with GOP.
This study investigated the effects of gut hormone infusion on food preferences and energy intake after gastric bypass surgery, finding no significant changes in food preferences despite a reduction in energy intake.
Quick read
The essential study design details in one scan.
EvidenceScore™
Moderate
Study type
RCTs
Follow-up
Medium-Term (3–12 mo)
Risk of bias
Some Concerns
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Plain-language summary
A plain-language read of the study’s main message and where it applies.
Study focus
This study investigated the effects of gut hormone infusion on food preferences and energy intake after gastric bypass surgery, finding no significant changes in food preferences despite a reduction in energy intake.
Understanding the impact of gut hormones on food intake and preferences is crucial for developing effective obesity treatments. This study suggests that while gut hormones can reduce energy intake, they may not influence food choices, which is important for dietary management post-surgery.
Study design limited to a small participant sample. Findings may not be generalizable to broader populations. No long-term follow-up data on dietary habits or weight changes.
Published in
Publication details and source links for this paper.
Preeshila B, Haya A, Alexander DM, et al. The elevation in plasma gut hormone concentrations after Roux-en-Y gastric bypass is unlikely to mediate changes in food preferences. Diabetes, Obesity & Metabolism. 2023;25(6):1731-1739. doi:10.1111/dom.15028
Mean daily energy intake was reduced by 27% with GOP infusion (p=0.001).
No significant changes in food preferences were observed after GOP infusion.
GOP infusion did not alter sweet taste detection thresholds or the intensity of sweet taste.
Evidence network
Understand where this research contributes within the broader evidence network.
This study contributes evidence to GOP infusion and Consummatory reward value of sweet taste, Food preference, Mean difference in reported energy intake, and 4 more.
This study contributes evidence to
Primary intervention
GOP infusion
Primary outcomes
Primary intervention
Intervention and outcome relationships this study adds to the evidence network.
Editorial context
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Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
0
Related topics
7
Evidence pairs
0
Related studies
Core evidence
The primary outcomes reported in this study.
GOP infusion → Consummatory reward value of sweet taste
GOP infusion → Consummatory reward value of sweet taste
GOP infusion → Mean difference in reported energy intake
GOP infusion → Mean difference in reported energy intake
GOP infusion → No alteration in the intensity of sweet taste
GOP infusion → No alteration in the intensity of sweet taste
GOP infusion → No change in corrected hit rates for sucrose detection
GOP infusion → No change in corrected hit rates for sucrose detection
GOP infusion → Reduction in Restraint Eating
GOP infusion → Reduction in Restraint Eating
GOP infusion → Sweet taste detection thresholds
GOP infusion → Sweet taste detection thresholds
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Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on GOP infusion and Consummatory reward value of sweet taste, GOP infusion and No change in corrected hit rates for sucrose detection.
This study contributes to the evidence on the following intervention-outcome relationships.
Curated evidence collections and hubs this study is part of.
All studies measuring Consummatory reward value of sweet taste
Measures Consummatory reward value of sweet taste as a key outcome.
All studies on GOP infusion
Contributes to GOP infusion evidence base.
All studies measuring No change in corrected hit rates for sucrose detection
Measures No change in corrected hit rates for sucrose detection as a key outcome.
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1 results
1 results
1 results
1 results
1 results
Generated from the study's connected evidence using Evidence Intelligence™.
GOP infusion appears to improve mean difference in reported energy intake.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Mean difference in reported energy intake
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
GOP infusion appears to reduce reduction in restraint eating.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Reduction in Restraint Eating
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Current evidence does not show a clear benefit of GOP infusion for consummatory reward value of sweet taste.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Consummatory reward value of sweet taste
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | neutral | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Current evidence does not show a clear benefit of GOP infusion for food preference.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Food preference
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | neutral | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
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