Key finding
Intensive therapy was associated with a risk reduction in onset of retinopathy (HR, 0.83; 95% CI, 0.70-0.98; P = .03).
The J-DOIT3 trial analyzed the effects of intensified multifactorial intervention on glycemic management in type 2 diabetes, finding that intensive therapy reduced the risk of retinopathy onset.
Evidence strength
Moderate confidence
Study type
RCTs
Follow-up
Extended (5–20+ y)
Quick read
The essential study design details in one scan.
Population
Young Adult (19–39), Middle Aged (40-64), Male, Female, Asia-Pacific (APAC), with T2 Diabetes
Intervention
Intensive therapy for glucose, blood pressure, and lipids
Study type
RCTs
Follow-up
Extended (5–20+ y)
Primary outcome
Onset of retinopathy
Comparator
Conventional Therapy Group
Plain-language summary
A plain-language read of the study's main message and where it applies.
Study focus
The J-DOIT3 trial analyzed the effects of intensified multifactorial intervention on glycemic management in type 2 diabetes, finding that intensive therapy reduced the risk of retinopathy onset.
These findings are significant for clinicians managing patients with type 2 diabetes, as they highlight the importance of intensive therapy in preventing complications like retinopathy. By reducing the onset of such complications, healthcare providers can improve long-term outcomes and quality of life for their patients.
The study did not provide data on loss of vision due to retinopathy. Effectiveness of interventions was unclear for some outcomes. Limited generalizability due to specific population characteristics.
Published in
Publication details and source links for this paper.
Takayoshi S, Kohjiro U, Kengo M, et al. Intensified Multifactorial Intervention and Glycemic Management in Type 2 Diabetes: A Secondary Analysis of the J-DOIT3 Trial. JAMA Ophthalmology. 2025;143(12):989-997. doi:10.1001/jamaophthalmol.2025.3819
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Intensive therapy reduced the risk of onset of retinopathy (HR, 0.83; P = .03).
Intensive therapy did not affect the progression of retinopathy (HR, 1.02; P = .93).
No specific data was provided on loss of vision due to retinopathy.
Evidence network
Understand where this research contributes within the broader evidence network.
This study contributes evidence to Telephone-based lifestyle education for gestational diabetes prevention and Diabetic retinopathy incidence, Loss of vision likely due to retinopathy, Retinopathy progression.
This study contributes evidence to
Primary intervention
Telephone-based lifestyle education for gestational diabetes prevention
Primary outcomes
Intervention and outcome relationships this study adds to the evidence network.
Editorial context
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Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
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Related topics
3
Evidence pairs
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Related studies
Core evidence
The primary outcomes reported in this study.
Telephone-based lifestyle education for gestational diabetes prevention → Diabetic retinopathy incidence
Telephone-based lifestyle education for gestational diabetes prevention → Diabetic retinopathy incidence
Evidence profile
Telephone-based lifestyle education for gestational diabetes prevention → Loss of vision likely due to retinopathy
Telephone-based lifestyle education for gestational diabetes prevention → Loss of vision likely due to retinopathy
Evidence profile
Telephone-based lifestyle education for gestational diabetes prevention → Retinopathy progression
Telephone-based lifestyle education for gestational diabetes prevention → Retinopathy progression
Evidence profile
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Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on Telephone-based lifestyle education for gestational diabetes prevention and Retinopathy.
This study contributes to the evidence on the following intervention-outcome relationships.
Behavioral & Lifestyle
Curated evidence collections and hubs this study is part of.
All studies measuring Retinopathy
Measures Retinopathy as a key outcome.
All studies on Telephone-based lifestyle education for gestational diabetes prevention
Contributes to Telephone-based lifestyle education for gestational diabetes prevention evidence base.
Latest published studies
Published within the last 2 years.
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1 results
1 results
1 results
Generated from the study's connected evidence using Evidence Intelligence™.
Telephone-based lifestyle education for gestational diabetes prevention appears to improve Diabetic retinopathy incidence.
ConsensusScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Diabetic retinopathy incidence
EvidenceScore™ Emerging | EvidenceScore™ 55.7 | strong positive | ConsensusScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Current evidence does not show a clear benefit of Telephone-based lifestyle education for gestational diabetes prevention for Loss of vision likely due to retinopathy.
ConsensusScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Loss of vision likely due to retinopathy
EvidenceScore™ Limited | EvidenceScore™ 38.1 | neutral | ConsensusScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Current evidence does not show a clear benefit of Telephone-based lifestyle education for gestational diabetes prevention for Retinopathy progression.
ConsensusScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Retinopathy progression
EvidenceScore™ Limited | EvidenceScore™ 38.1 | neutral | ConsensusScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
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