Last updated July 22, 2026
Key finding
The microbiological analysis showed a significant reduction in microbial count from (S1) to (S2) in all the study groups.
This study evaluated the antimicrobial efficacy of three intracanal medicaments in Type II diabetes patients with chronic apical periodontitis, finding significant reductions in microbial counts.
Quick read
The essential study design details in one scan.
EvidenceScore™
Moderate
Study type
RCTs
Follow-up
Short-Term (≤3 mo)
Risk of bias
Some Concerns
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Plain-language summary
A plain-language read of the study’s main message and where it applies.
Study focus
This study evaluated the antimicrobial efficacy of three intracanal medicaments in Type II diabetes patients with chronic apical periodontitis, finding significant reductions in microbial counts.
This study is significant as it addresses the treatment of chronic apical periodontitis in Type II diabetes patients, a group that may have compromised healing. Effective management of microbial infections is crucial for improving dental health outcomes in these patients, and understanding the efficacy of different medicaments can guide clinical practice.
Limited sample size may affect generalizability. Short follow-up period may not capture long-term efficacy. Potential confounding factors not controlled for.
Published in
Publication details and source links for this paper.
Chandrasekhar T, Sophia T. Antimicrobial Efficacy of Intracanal Medicaments in Type II Diabetes Patients with Chronic Apical Periodontitis. Contemporary Clinical Dentistry. 2019;10(2):191-196. doi:10.4103/ccd.ccd_195_18
Significant reduction of Enterococcus faecalis in all groups from S1 to S2.
Significant reduction of Streptococcus spp. in all groups from S1 to S2.
No significant difference in microbial load reduction between groups after one week.
Evidence network
Understand where this research contributes within the broader evidence network.
This study contributes evidence to A. soehngenii CH-106, Propolis with Moxifloxacin, Triple Antibiotic Paste and Comparison of microbial load reduction between groups, Reduction in microbial count of Enterococcus faecalis, Reduction in microbial count of Streptococcus spp..
This study contributes evidence to
Primary intervention
A. soehngenii CH-106
Primary outcomes
Intervention and outcome relationships this study adds to the evidence network.
Editorial context
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Evidence network role
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Related topics
9
Evidence pairs
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Related studies
Core evidence
The primary outcomes reported in this study.
A. soehngenii CH-106 → Comparison of microbial load reduction between groups
A. soehngenii CH-106 → Comparison of microbial load reduction between groups
A. soehngenii CH-106 → Reduction in microbial count of Enterococcus faecalis
A. soehngenii CH-106 → Reduction in microbial count of Enterococcus faecalis
A. soehngenii CH-106 → Reduction in microbial count of Streptococcus spp.
A. soehngenii CH-106 → Reduction in microbial count of Streptococcus spp.
Propolis with Moxifloxacin → Comparison of microbial load reduction between groups
Propolis with Moxifloxacin → Comparison of microbial load reduction between groups
Propolis with Moxifloxacin → Reduction in microbial count of Enterococcus faecalis
Propolis with Moxifloxacin → Reduction in microbial count of Enterococcus faecalis
Propolis with Moxifloxacin → Reduction in microbial count of Streptococcus spp.
Propolis with Moxifloxacin → Reduction in microbial count of Streptococcus spp.
Triple Antibiotic Paste → Comparison of microbial load reduction between groups
Triple Antibiotic Paste → Comparison of microbial load reduction between groups
Triple Antibiotic Paste → Reduction in microbial count of Enterococcus faecalis
Triple Antibiotic Paste → Reduction in microbial count of Enterococcus faecalis
Triple Antibiotic Paste → Reduction in microbial count of Streptococcus spp.
Triple Antibiotic Paste → Reduction in microbial count of Streptococcus spp.
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Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on A. soehngenii CH-106 and Comparison of microbial load reduction between groups, A. soehngenii CH-106 and Reduction in microbial count of Enterococcus faecalis.
This study contributes to the evidence on the following intervention-outcome relationships.
Curated evidence collections and hubs this study is part of.
All studies on A. soehngenii CH-106
Contributes to A. soehngenii CH-106 evidence base.
All studies measuring Comparison of microbial load reduction between groups
Measures Comparison of microbial load reduction between groups as a key outcome.
All studies measuring Reduction in microbial count of Enterococcus faecalis
Measures Reduction in microbial count of Enterococcus faecalis as a key outcome.
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1 results
1 results
1 results
1 results
1 results
Generated from the study's connected evidence using Evidence Intelligence™.
A. soehngenii CH-106 appears to improve Reduction in microbial count of Enterococcus faecalis.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Reduction in microbial count of Enterococcus faecalis
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
A. soehngenii CH-106 appears to improve Reduction in microbial count of Streptococcus spp..
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Reduction in microbial count of Streptococcus spp.
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Propolis with Moxifloxacin appears to improve Reduction in microbial count of Enterococcus faecalis.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Reduction in microbial count of Enterococcus faecalis
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Propolis with Moxifloxacin appears to improve Reduction in microbial count of Streptococcus spp..
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Reduction in microbial count of Streptococcus spp.
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
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