StrongDecrease
Blood lactate concentration
Aspirin → Blood lactate concentration
Aspirin → Blood lactate concentration
Evidence profile
StrongDecreaseMetabolic Health
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Research Summary
Analyzed using Evidence Intelligence™
Linking Eye Screening Data Improves Understanding of Diabetes Treatments
Key finding
Blood lactate concentration decreased significantly.
The ASCEND-Eye study assessed the effects of aspirin and omega-3 fatty acids on diabetic eye screening data, finding significant reductions in blood lactate and growth differentiation factor 15.
Evidence strength
Moderate confidence
Study type
RCTs
Follow-up
Extended (5–20+ y)
Some Concerns bias
Last updated July 5, 2026Quick read
Study at a glance
The essential study design details in one scan.
Population
Middle Aged (40-64), Male, Female, Europe (EU & UK), with T2 Diabetes
Intervention
Aspirin, Omega-3 Fatty Acid Supplementation, Placebo
Study type
RCTs
Follow-up
Extended (5–20+ y)
Primary outcome
Blood lactate concentration
Comparator
Placebo
Plain-language summary
What this paper says
A plain-language read of the study's main message and where it applies.
Study focus
The ASCEND-Eye study assessed the effects of aspirin and omega-3 fatty acids on diabetic eye screening data, finding significant reductions in blood lactate and growth differentiation factor 15.
Clinical relevance
These findings are clinically significant as they suggest that aspirin and omega-3 fatty acids could potentially improve metabolic markers in diabetic patients, which may help in managing diabetes and preventing complications. Improved recognition of hypoglycemia symptoms is particularly important for patient safety.
Keep in mind
Study design was non-randomized, which may introduce bias. Effectiveness of interventions remains unclear due to limited evidence. Sample size and demographic details were not specified.
Published in
Journal Reference
Publication details and source links for this paper.
Emily S, Louise B, Marion M, Jane A. ASCEND-Eye: Linking Diabetic Eye Screening Data to Assess Aspirin and Omega-3 Fatty Acids Effects. Contemporary Clinical Trials Communications. 2025;45:101474. doi:10.1016/j.conctc.2025.101474
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Main Effects
Blood lactate concentration decreased significantly by 0.5 mmol/L (p=0.01).
Growth differentiation factor 15 decreased significantly by 10 pg/mL (p=0.05).
Hypoglycemia symptom recognition ability improved significantly by 2 score points (p=0.02).
Evidence network
How this study fits
Understand where this research contributes within the broader evidence network.
Evidence Context
This study contributes evidence to Aspirin, Omega-3 Fatty Acid Supplementation and Blood lactate concentration, Hypoglycemia symptom recognition ability, Growth differentiation factor 15.
This study contributes evidence to
Primary intervention
Aspirin
Primary outcomes
- Blood lactate concentration
- Hypoglycemia symptom recognition ability
- Growth differentiation factor 15
Primary intervention
Evidence relationships
Intervention and outcome relationships this study adds to the evidence network.
3
Evidence pairs
3
Relationships
0
Evidence topics
contributes_evidence
Editorial context
Why this study matters
See why this paper is useful beyond its individual results.
Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
Moderate contributionModerate confidenceNetwork score: 54
0
Related topics
3
Evidence pairs
0
Related studies
Why it is useful
- Contributes to 3 evidence relationships
- Includes primary outcome data
- Linked to 0 direct semantic evidence topics
Core evidence
Study findings
The primary outcomes reported in this study.
StrongIncrease
Hypoglycemia symptom recognition ability
Aspirin → Hypoglycemia symptom recognition ability
Aspirin → Hypoglycemia symptom recognition ability
Evidence profile
StrongIncreaseAdherence & Engagement
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StrongDecrease
Growth differentiation factor 15
Omega-3 Fatty Acid Supplementation → Growth differentiation factor 15
Omega-3 Fatty Acid Supplementation → Growth differentiation factor 15
Evidence profile
StrongDecreaseMetabolic Health
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Evidence Suggest
- Blood lactate levels decreased significantly with aspirin and omega-3 supplementation.
- Growth differentiation factor 15 levels also decreased significantly.
- Hypoglycemia symptom recognition improved significantly among participants.
Who this applies to
- Adults with diabetes.
- Patients undergoing diabetic eye screening.
Keep in Mind
- Results may not be generalizable to all diabetic populations.
- Further research is needed to confirm findings and establish clinical guidelines.
- The study did not assess long-term effects of the interventions.
Between the Lines
- Study design was non-randomized, which may introduce bias.
- Effectiveness of interventions remains unclear due to limited evidence.
- Sample size and demographic details were not specified.
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Connected Evidence
Explore related studies, evidence collections, and research questions.
Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on Aspirin and Blood lactate concentration, Aspirin and Hypoglycemia symptom recognition ability.
Related evidence relationships
Explore in Evidence ArchiveThis study contributes to the evidence on the following intervention-outcome relationships.
Included in these evidence collections
Curated evidence collections and hubs this study is part of.
Aspirin Evidence Hub
All studies on Aspirin
1 studies
intervention_hubContributes to Aspirin evidence base.
Blood lactate concentration Evidence Hub
All studies measuring Blood lactate concentration
1 studies
outcome_hubMeasures Blood lactate concentration as a key outcome.
Hypoglycemia symptom recognition ability Evidence Hub
All studies measuring Hypoglycemia symptom recognition ability
1 studies
outcome_hubMeasures Hypoglycemia symptom recognition ability as a key outcome.
Recent Diabetes Research
Latest published studies
recency_collection
Published within the last 2 years.
Explore more in the evidence archive
Jump to pre-filtered views in the evidence archive.
All studies on Aspirin and Blood lactate concentration
Intervention: AspirinOutcome: Blood lactate concentration
1 results
All studies on Aspirin and Hypoglycemia symptom recognition ability
Intervention: AspirinOutcome: Hypoglycemia symptom recognition ability
1 results
All studies on Aspirin
Intervention: Aspirin
1 results
All studies measuring Blood lactate concentration
Outcome: Blood lactate concentration
1 results
All studies measuring Hypoglycemia symptom recognition ability
Outcome: Hypoglycemia symptom recognition ability
1 results
Questions answered by this study
Generated from the study's connected evidence using Evidence Intelligence™.
Does Aspirin improve blood lactate concentration?
Emerging Evidence
Aspirin appears to improve Blood lactate concentration.
ConsensusScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
- 1
Blood lactate concentration
EvidenceScore™ Emerging | EvidenceScore™ 52.9 | strong positive | ConsensusScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
- Only one supporting study is available.
- Consistency cannot yet be determined.
- Population details are unavailable.
Does Aspirin affect hypoglycemia symptom recognition ability?
Emerging Evidence
Aspirin appears to improve Hypoglycemia symptom recognition ability.
ConsensusScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
- 1
Hypoglycemia symptom recognition ability
EvidenceScore™ Emerging | EvidenceScore™ 52.9 | strong positive | ConsensusScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
- Only one supporting study is available.
- Consistency cannot yet be determined.
- Population details are unavailable.
Does Omega-3 Fatty Acid Supplementation improve growth differentiation factor 15?
Emerging Evidence
Omega-3 Fatty Acid Supplementation appears to improve Growth differentiation factor 15.
ConsensusScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
- 1
Growth differentiation factor 15
EvidenceScore™ Emerging | EvidenceScore™ 52.9 | strong positive | ConsensusScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
- Only one supporting study is available.
- Consistency cannot yet be determined.
- Population details are unavailable.
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