Last updated July 5, 2026
Key finding
Blood lactate concentration decreased significantly.
The ASCEND-Eye study assessed the effects of aspirin and omega-3 fatty acids on diabetic eye screening data, finding significant reductions in blood lactate and growth differentiation factor 15.
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EvidenceScore™
Moderate
Study type
RCTs
Follow-up
Extended (5–20+ y)
Risk of bias
Some Concerns
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Plain-language summary
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Study focus
The ASCEND-Eye study assessed the effects of aspirin and omega-3 fatty acids on diabetic eye screening data, finding significant reductions in blood lactate and growth differentiation factor 15.
These findings are clinically significant as they suggest that aspirin and omega-3 fatty acids could potentially improve metabolic markers in diabetic patients, which may help in managing diabetes and preventing complications. Improved recognition of hypoglycemia symptoms is particularly important for patient safety.
Study design was non-randomized, which may introduce bias. Effectiveness of interventions remains unclear due to limited evidence. Sample size and demographic details were not specified.
Published in
Publication details and source links for this paper.
Emily S, Louise B, Marion M, Jane A. ASCEND-Eye: Linking Diabetic Eye Screening Data to Assess Aspirin and Omega-3 Fatty Acids Effects. Contemporary Clinical Trials Communications. 2025;45:101474. doi:10.1016/j.conctc.2025.101474
Blood lactate concentration decreased significantly by 0.5 mmol/L (p=0.01).
Growth differentiation factor 15 decreased significantly by 10 pg/mL (p=0.05).
Hypoglycemia symptom recognition ability improved significantly by 2 score points (p=0.02).
Evidence network
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This study contributes evidence to Aspirin, Omega-3 Fatty Acid Supplementation and Blood lactate concentration, Hypoglycemia symptom recognition ability, Growth differentiation factor 15.
This study contributes evidence to
Primary intervention
Aspirin
Primary outcomes
Primary intervention
Intervention and outcome relationships this study adds to the evidence network.
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Evidence network role
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Primary evidence
Evidence relationship
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Intervention
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Outcome
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Core evidence
The primary outcomes reported in this study.
Aspirin → Blood lactate concentration
Aspirin → Blood lactate concentration
Aspirin → Hypoglycemia symptom recognition ability
Aspirin → Hypoglycemia symptom recognition ability
Omega-3 Fatty Acid Supplementation → Growth differentiation factor 15
Omega-3 Fatty Acid Supplementation → Growth differentiation factor 15
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Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on Aspirin and Blood lactate concentration, Aspirin and Hypoglycemia symptom recognition ability.
This study contributes to the evidence on the following intervention-outcome relationships.
Medications
Curated evidence collections and hubs this study is part of.
All studies on Aspirin
Contributes to Aspirin evidence base.
All studies measuring Blood lactate concentration
Measures Blood lactate concentration as a key outcome.
All studies measuring Hypoglycemia symptom recognition ability
Measures Hypoglycemia symptom recognition ability as a key outcome.
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Published within the last 2 years.
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1 results
1 results
1 results
1 results
1 results
Generated from the study's connected evidence using Evidence Intelligence™.
Omega-3 Fatty Acid Supplements appears to improve Inflammatory Markers.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Growth differentiation factor 15
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Aspirin appears to improve Blood lactate concentration.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Blood lactate concentration
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Aspirin appears to improve Hypoglycemia symptom recognition ability.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Hypoglycemia symptom recognition ability
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
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