StrongIncrease
Adherence to aspirin
Aspirin → Adherence to aspirin
Aspirin → Adherence to aspirin
Evidence profile
StrongIncreaseAdherence & Engagement
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Research Summary
Analyzed using Evidence Intelligence™
Women and frailty linked to poorer adherence in diabetes trial
Key finding
7312 (47.2%) participants were fully adherent to aspirin.
The ASCEND study investigated cardiovascular events in diabetic participants through a randomized controlled trial involving aspirin and omega-3 fatty acid supplementation.
Evidence strength
Moderate confidence
Study type
RCTs
Follow-up
Extended (5–20+ y)
Some Concerns bias
Last updated July 3, 2026Quick read
Study at a glance
The essential study design details in one scan.
Population
Young Adult (19–39), Middle Aged (40-64), Male, Female, Asia-Pacific (APAC), with T2 Diabetes
Intervention
Aspirin, Placebo, Omega-3 Fatty Acid Supplementation, Placebo for Omega-3
Study type
RCTs
Follow-up
Extended (5–20+ y)
Primary outcome
Adherence to Aspirin
Comparator
Placebo for Aspirin, Placebo for Omega-3
Plain-language summary
What this paper says
A plain-language read of the study's main message and where it applies.
Study focus
The ASCEND study investigated cardiovascular events in diabetic participants through a randomized controlled trial involving aspirin and omega-3 fatty acid supplementation.
Clinical relevance
Understanding adherence rates and predictors is crucial for improving treatment strategies in diabetic patients at risk for cardiovascular events. This study highlights the need for targeted interventions to enhance adherence, which can ultimately lead to better health outcomes.
Keep in mind
Effectiveness of interventions remains unclear. Adherence rates may not reflect long-term outcomes. Generalizability may be limited to specific diabetic populations.
Published in
Journal Reference
Publication details and source links for this paper.
Vichithranie WM, Marion M, Georgina B, Louise B, Jane A. ASCEND: A Study of Cardiovascular Events in Diabetes. Trials. 2026;27:183. doi:10.1186/s13063-026-09551-4
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Main Effects
7312 participants (47.2%) were fully adherent to aspirin.
8937 participants (57.7%) were fully adherent to omega-3.
Adherence decreased with increasing frailty, smoking, and vascular risk score.
Evidence network
How this study fits
Understand where this research contributes within the broader evidence network.
Evidence Context
This study contributes evidence to Aspirin, Omega-3 Fatty Acid Supplementation and Adherence to aspirin, Treatment adherence, Adherence Predictors for Omega-3, and 1 more.
This study contributes evidence to
Primary intervention
Aspirin
Primary outcomes
- Adherence to aspirin
- Treatment adherence
- Adherence Predictors for Omega-3
Evidence topics
Primary intervention
Evidence relationships
Intervention and outcome relationships this study adds to the evidence network.
4
Evidence pairs
4
Relationships
1
Evidence topics
contributes_evidence
Editorial context
Why this study matters
See why this paper is useful beyond its individual results.
Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
Moderate contributionModerate confidenceNetwork score: 63
1
Related topics
4
Evidence pairs
45
Related studies
High relevance in at least one topic
Why it is useful
- Contributes to 4 evidence relationships
- Includes primary outcome data
- Linked to 1 direct semantic evidence topic
Topic contributions
Evidence topic
Contributes evidence
Core evidence
Study findings
The primary outcomes reported in this study.
NoneNo Change
Treatment adherence
Aspirin → Treatment adherence
Aspirin → Treatment adherence
Evidence profile
NoneNo ChangeAdherence & Engagement
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NoneNo Change
Adherence Predictors for Omega-3
Omega-3 Fatty Acid Supplementation → Adherence Predictors for Omega-3
Omega-3 Fatty Acid Supplementation → Adherence Predictors for Omega-3
Evidence profile
NoneNo ChangeAdherence & Engagement
Unlock full evidence details
StrongIncrease
Adherence to Omega-3
Omega-3 Fatty Acid Supplementation → Adherence to Omega-3
Omega-3 Fatty Acid Supplementation → Adherence to Omega-3
Evidence profile
StrongIncreaseAdherence & Engagement
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Evidence Suggest
- 47.2% adherence to aspirin and placebo.
- 57.7% adherence to omega-3 and its placebo.
- Adherence predictors included frailty, smoking, and vascular risk.
Who this applies to
- Adults with diabetes.
- Individuals at risk for cardiovascular events.
Keep in Mind
- The study's effectiveness findings are unclear.
- Adherence rates may vary in different populations.
- Results may not apply to non-diabetic individuals.
Between the Lines
- Effectiveness of interventions remains unclear.
- Adherence rates may not reflect long-term outcomes.
- Generalizability may be limited to specific diabetic populations.
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Connected Evidence
Explore related studies, evidence collections, and research questions.
Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on Aspirin and Treatment Adherence, Omega-3 Fatty Acid Supplementation and Treatment Adherence.
Related evidence relationships
Explore in Evidence ArchiveThis study contributes to the evidence on the following intervention-outcome relationships.
Included in these evidence collections
Curated evidence collections and hubs this study is part of.
Aspirin Evidence Hub
All studies on Aspirin
1 studies
intervention_hubContributes to Aspirin evidence base.
Omega-3 Fatty Acid Supplementation Evidence Hub
All studies on Omega-3 Fatty Acid Supplementation
1 studies
intervention_hubContributes to Omega-3 Fatty Acid Supplementation evidence base.
Treatment Adherence Evidence Hub
All studies measuring Treatment Adherence
1 studies
outcome_hubMeasures Treatment Adherence as a key outcome.
Recent Diabetes Research
Latest published studies
recency_collection
Published within the last 2 years.
Explore more in the evidence archive
Jump to pre-filtered views in the evidence archive.
All studies on Aspirin and Adherence to aspirin
Intervention: AspirinOutcome: Adherence to aspirin
1 results
All studies on Omega-3 Fatty Acid Supplementation and Adherence to Omega-3
Intervention: Omega-3 Fatty Acid SupplementationOutcome: Adherence to Omega-3
1 results
All studies on Aspirin
Intervention: Aspirin
1 results
All studies on Omega-3 Fatty Acid Supplementation
Intervention: Omega-3 Fatty Acid Supplementation
1 results
All studies measuring Adherence to aspirin
Outcome: Adherence to aspirin
1 results
Questions answered by this study
Generated from the study's connected evidence using Evidence Intelligence™.
Does Aspirin improve adherence to aspirin?
Emerging Evidence
Aspirin appears to improve Adherence to aspirin.
ConsensusScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
- 1
Adherence to aspirin
EvidenceScore™ Emerging | EvidenceScore™ 55.7 | strong positive | ConsensusScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
- Only one supporting study is available.
- Consistency cannot yet be determined.
- Population details are unavailable.
Does Omega-3 Fatty Acid Supplementation improve adherence to omega-3?
Emerging Evidence
Omega-3 Fatty Acid Supplementation appears to improve Adherence to Omega-3.
ConsensusScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
- 1
Adherence to Omega-3
EvidenceScore™ Emerging | EvidenceScore™ 55.7 | strong positive | ConsensusScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
- Only one supporting study is available.
- Consistency cannot yet be determined.
- Population details are unavailable.
Does Aspirin improve treatment adherence?
Limited Evidence
Current evidence does not show a clear benefit of Aspirin for Treatment adherence.
ConsensusScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
- 1
Treatment adherence
EvidenceScore™ Limited | EvidenceScore™ 38.1 | neutral | ConsensusScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
- Only one supporting study is available.
- Consistency cannot yet be determined.
- Population details are unavailable.
Does Omega-3 Fatty Acid Supplementation improve adherence predictors for omega-3?
Limited Evidence
Current evidence does not show a clear benefit of Omega-3 Fatty Acid Supplementation for Adherence Predictors for Omega-3.
ConsensusScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
- 1
Adherence Predictors for Omega-3
EvidenceScore™ Limited | EvidenceScore™ 38.1 | neutral | ConsensusScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
- Only one supporting study is available.
- Consistency cannot yet be determined.
- Population details are unavailable.
Next steps
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