NoneNo Change
Diastolic blood pressure
Multifactorial interventions → Diastolic blood pressure
Multifactorial interventions → Diastolic blood pressure
Evidence profile
NoneNo ChangeMetabolic Health
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Research Summary
Analyzed using Evidence Intelligence™
Multifactorial interventions improve diabetes control in Emirati patients
Key finding
A significant mean difference of -0.36% in HbA1c levels between the groups (95% CI: -0.54 – -0.19, P < 0.01)
This study evaluated the effects of long-term multifactorial interventions on clinical outcomes in Emirati patients with diabetes, finding significant improvements in HbA1c and LDL-C levels.
Evidence strength
Moderate confidence
Study type
RCTs
Follow-up
Long-Term (1–5 y)
Some Concerns bias
Last updated July 6, 2026Quick read
Study at a glance
The essential study design details in one scan.
Population
Young Adult (19–39), Middle Aged (40-64), Male, Female, Asia-Pacific (APAC), with T2 Diabetes
Intervention
Multifactorial interventions
Study type
RCTs
Follow-up
Long-Term (1–5 y)
Primary outcome
Glycated haemoglobin A1c (HbA1c)
Comparator
Standard routine care
Plain-language summary
What this paper says
A plain-language read of the study's main message and where it applies.
Study focus
This study evaluated the effects of long-term multifactorial interventions on clinical outcomes in Emirati patients with diabetes, finding significant improvements in HbA1c and LDL-C levels.
Clinical relevance
These findings highlight the importance of multifactorial interventions in managing diabetes, particularly in reducing key risk factors like HbA1c and LDL-C. Effective management of these parameters can lead to better long-term health outcomes for patients with diabetes, potentially reducing the risk of complications associated with the disease.
Keep in mind
Limited generalizability due to the specific population studied No significant changes in blood pressure outcomes Unclear effectiveness for some outcomes
Published in
Journal Reference
Publication details and source links for this paper.
Marwan E, Luai A, Jeffrey K, et al. Effects of long-term multifactorial interventions on clinical outcomes in Emirati patients with diabetes. PLOS One. 2025;20(7):e0327211. doi:10.1371/journal.pone.0327211
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Main Effects
HbA1c levels decreased by -0.36% (P < 0.01)
LDL-C levels decreased by -0.14 mmol/L (P < 0.03)
eGFR levels increased by 3.93 mL/min/1.73 m² (P < 0.01)
Evidence network
How this study fits
Understand where this research contributes within the broader evidence network.
Evidence Context
This study contributes evidence to Multifactorial interventions and Diastolic blood pressure, Estimated glomerular filtration rate, HbA1c, and 3 more.
This study contributes evidence to
Primary intervention
Multifactorial interventions
Primary outcomes
- Diastolic blood pressure
- Estimated glomerular filtration rate
- HbA1c
Evidence topics
Primary intervention
Evidence relationships
Intervention and outcome relationships this study adds to the evidence network.
6
Evidence pairs
6
Relationships
1
Evidence topics
contributes_evidence
Editorial context
Why this study matters
See why this paper is useful beyond its individual results.
Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
Moderate contributionModerate confidenceNetwork score: 63
1
Related topics
6
Evidence pairs
161
Related studies
High relevance in at least one topic
Why it is useful
- Contributes to 6 evidence relationships
- Includes primary outcome data
- Linked to 1 direct semantic evidence topic
Topic contributions
Evidence topic
Contributes evidence
Core evidence
Study findings
The primary outcomes reported in this study.
StrongIncrease
Estimated glomerular filtration rate
Multifactorial interventions → Estimated glomerular filtration rate
Multifactorial interventions → Estimated glomerular filtration rate
Evidence profile
StrongIncreaseClinical Outcomes
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StrongDecrease
HbA1c
Multifactorial interventions → HbA1c
Multifactorial interventions → HbA1c
Evidence profile
StrongDecreaseGlycemic Control
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StrongDecrease
LDL cholesterol
Multifactorial interventions → LDL cholesterol
Multifactorial interventions → LDL cholesterol
Evidence profile
StrongDecreaseMetabolic Health
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StrongIncrease
Percentage of participants achieving blood pressure target
Multifactorial interventions → Percentage of participants achieving blood pressure target
Multifactorial interventions → Percentage of participants achieving blood pressure target
Evidence profile
StrongIncreaseClinical Outcomes
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NoneNo Change
Systolic blood pressure
Multifactorial interventions → Systolic blood pressure
Multifactorial interventions → Systolic blood pressure
Evidence profile
NoneNo ChangeMetabolic Health
Unlock full evidence details
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Evidence Suggest
- HbA1c reduced by -0.36%, indicating improved blood sugar control.
- LDL-C decreased by -0.14 mmol/L, suggesting better cholesterol management.
- eGFR improved by 3.93 mL/min/1.73 m², indicating enhanced kidney function.
Who this applies to
- Emirati patients diagnosed with diabetes
- Adults aged 18 and older with diabetes
Keep in Mind
- Results may not apply to non-Emirati populations.
- The study did not find significant changes in blood pressure.
- Further research is needed to explore long-term effects.
Between the Lines
- Limited generalizability due to the specific population studied
- No significant changes in blood pressure outcomes
- Unclear effectiveness for some outcomes
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Connected Evidence
Explore related studies, evidence collections, and research questions.
Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on Multifactorial interventions and Kidney Function, Multifactorial interventions and HbA1c.
Related evidence relationships
Explore in Evidence ArchiveThis study contributes to the evidence on the following intervention-outcome relationships.
Multifactorial interventionsAdipokine and Angiogenic Markers
Behavioral & Lifestyle
1 studies
Detailed evidenceIncluded in these evidence collections
Curated evidence collections and hubs this study is part of.
Adipokine and Angiogenic Markers Evidence Hub
All studies measuring Adipokine and Angiogenic Markers
1 studies
outcome_hubMeasures Adipokine and Angiogenic Markers as a key outcome.
HbA1c Evidence Hub
All studies measuring HbA1c
1 studies
outcome_hubMeasures HbA1c as a key outcome.
Kidney Function Evidence Hub
All studies measuring Kidney Function
1 studies
outcome_hubMeasures Kidney Function as a key outcome.
Multifactorial interventions Evidence Hub
All studies on Multifactorial interventions
1 studies
intervention_hubContributes to Multifactorial interventions evidence base.
Recent Diabetes Research
Latest published studies
recency_collection
Published within the last 2 years.
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All studies on Multifactorial interventions and Estimated glomerular filtration rate
Intervention: Multifactorial interventionsOutcome: Estimated glomerular filtration rate
1 results
All studies on Multifactorial interventions and HbA1c
Intervention: Multifactorial interventionsOutcome: HbA1c
1 results
All studies on Multifactorial interventions
Intervention: Multifactorial interventions
1 results
All studies measuring Estimated glomerular filtration rate
Outcome: Estimated glomerular filtration rate
1 results
All studies measuring HbA1c
Outcome: HbA1c
1 results
Questions answered by this study
Generated from the study's connected evidence using Evidence Intelligence™.
Does Multifactorial interventions improve estimated glomerular filtration rate?
Emerging Evidence
Multifactorial interventions appears to improve Estimated glomerular filtration rate.
ConsensusScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
- 1
Estimated glomerular filtration rate
EvidenceScore™ Emerging | EvidenceScore™ 54.2 | strong positive | ConsensusScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
- Only one supporting study is available.
- Consistency cannot yet be determined.
- Population details are unavailable.
Does Multifactorial interventions improve HbA1c?
Emerging Evidence
Multifactorial interventions appears to improve HbA1c.
ConsensusScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
- 1
HbA1c
EvidenceScore™ Emerging | EvidenceScore™ 54.2 | strong positive | ConsensusScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
- Only one supporting study is available.
- Consistency cannot yet be determined.
- Population details are unavailable.
Does Multifactorial interventions improve ldl cholesterol?
Emerging Evidence
Multifactorial interventions appears to improve LDL cholesterol.
ConsensusScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
- 1
LDL cholesterol
EvidenceScore™ Emerging | EvidenceScore™ 54.2 | strong positive | ConsensusScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
- Only one supporting study is available.
- Consistency cannot yet be determined.
- Population details are unavailable.
Does Multifactorial interventions improve percentage of participants achieving blood pressure target?
Emerging Evidence
Multifactorial interventions appears to improve Percentage of participants achieving blood pressure target.
ConsensusScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
- 1
Percentage of participants achieving blood pressure target
EvidenceScore™ Emerging | EvidenceScore™ 54.2 | strong positive | ConsensusScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
- Only one supporting study is available.
- Consistency cannot yet be determined.
- Population details are unavailable.
Next steps
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All studies on Multifactorial interventions and Estimated glomerular filtration rateAll studies on Multifactorial interventions and HbA1cAll studies on Multifactorial interventions and LDL cholesterolAll studies on Multifactorial interventions and Percentage of participants achieving blood pressure target
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