Last updated July 3, 2026
Key finding
Fasting blood glucose decreased significantly (p = 0.01 within-group effects, p = 0.03 interaction effects).
This study evaluated the effects of combined antioxidant and prebiotic supplementation on type 2 diabetes outcomes, finding significant improvements in fasting plasma glucose and glycated hemoglobin.
Quick read
The essential study design details in one scan.
EvidenceScore™
Moderate
Study type
RCTs
Follow-up
Short-Term (≤3 mo)
Risk of bias
Some Concerns
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Plain-language summary
A plain-language read of the study’s main message and where it applies.
Study focus
This study evaluated the effects of combined antioxidant and prebiotic supplementation on type 2 diabetes outcomes, finding significant improvements in fasting plasma glucose and glycated hemoglobin.
The findings highlight the potential of dietary supplements in managing type 2 diabetes, which is a growing health concern globally. Effective management strategies can lead to better health outcomes and reduced complications for patients with diabetes. This study provides evidence that combined antioxidant and prebiotic supplementation may serve as a complementary approach to traditional diabetes treatments.
Limited sample size may affect generalizability. Short duration of the study may not capture long-term effects. No assessment of potential confounding factors.
Published in
Publication details and source links for this paper.
Chompoonut T, Juntanee U, Jatuporn P, et al. Therapeutic Effects of Combined Antioxidant and Prebiotic Supplementation on Type 2 Diabetes Outcomes. Nutrients. 2025;17(7):1098. doi:10.3390/nu17071098
Fasting plasma glucose decreased by 1.5 mmol/L (p = 0.01).
Glycated hemoglobin decreased by 0.8% (p = 0.004).
Low density lipoprotein decreased by 0.5 mmol/L (p = 0.006).
Glomerular filtration rate improved by 5 mL/min (p = 0.01).
Evidence network
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This study contributes evidence to Combined antioxidant/prebiotic supplement and Estimated glomerular filtration rate, Fasting Plasma Glucose (FPG), HbA1c, and 1 more.
This study contributes evidence to
Primary intervention
Combined antioxidant/prebiotic supplement
Primary outcomes
Evidence topics
Primary intervention
Intervention and outcome relationships this study adds to the evidence network.
Editorial context
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Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
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4
Evidence pairs
793
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Evidence topic
Contributes evidence
Evidence topic
Contributes evidence
Evidence topic
Contributes evidence
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Primary evidence
Evidence relationship
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Evidence relationship
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Core evidence
The primary outcomes reported in this study.
Combined antioxidant/prebiotic supplement → Estimated glomerular filtration rate
Combined antioxidant/prebiotic supplement → Estimated glomerular filtration rate
Combined antioxidant/prebiotic supplement → Fasting Plasma Glucose (FPG)
Combined antioxidant/prebiotic supplement → Fasting Plasma Glucose (FPG)
Combined antioxidant/prebiotic supplement → HbA1c
Combined antioxidant/prebiotic supplement → HbA1c
Combined antioxidant/prebiotic supplement → LDL cholesterol
Combined antioxidant/prebiotic supplement → LDL cholesterol
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Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on Probiotics and Synbiotics and Kidney Function, Probiotics and Synbiotics and Fasting Glucose.
This study contributes to the evidence on the following intervention-outcome relationships.
Supplements
Supplements
Curated evidence collections and hubs this study is part of.
All studies measuring Adipokine and Angiogenic Markers
Measures Adipokine and Angiogenic Markers as a key outcome.
All studies measuring Fasting Glucose
Measures Fasting Glucose as a key outcome.
All studies measuring Kidney Function
Measures Kidney Function as a key outcome.
All studies on Probiotics and Synbiotics
Contributes to Probiotics and Synbiotics evidence base.
Latest published studies
Published within the last 2 years.
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1 results
1 results
1 results
1 results
1 results
Generated from the study's connected evidence using Evidence Intelligence™.
Probiotics and Synbiotics may improve Adipokine and Angiogenic Markers.
ConsistencyScore™: Results are generally consistent across studies.
Ranked evidence signals
LDL cholesterol
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on 9 supporting studies with generally consistent results and a positive effect signal.
Limitations
Probiotics and Synbiotics appears to improve HbA1c.
ConsistencyScore™: Results are consistent across studies.
Ranked evidence signals
HbA1c
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on 11 supporting studies with consistent results and a positive effect signal.
Limitations
Probiotics and Synbiotics may improve Fasting Glucose.
ConsistencyScore™: Results are generally consistent across studies.
Ranked evidence signals
Fasting Plasma Glucose (FPG)
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on 12 supporting studies with generally consistent results and a positive effect signal.
Limitations
Probiotics and Synbiotics appears to improve Kidney Function.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Estimated glomerular filtration rate
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
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