Last updated September 10, 2026
Key finding
FBG decreased from 195±6.57 to 172±5.83 in NS group.
Long-term supplementation with Nigella sativa improved glucose control and antioxidant levels in type 2 diabetic patients on oral medications.
Quick read
The essential study design details in one scan.
EvidenceScore™
Moderate
Study type
RCTs
Follow-up
Medium-Term (3–12 mo)
Risk of bias
Some Concerns
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Plain-language summary
A plain-language read of the study’s main message and where it applies.
Study focus
Long-term supplementation with Nigella sativa improved glucose control and antioxidant levels in type 2 diabetic patients on oral medications.
Improving glucose control and antioxidant defenses is crucial for managing type 2 diabetes and preventing complications. This study suggests that Nigella sativa could be a beneficial adjunct therapy for patients already on oral hypoglycemic agents.
Limited sample size may affect generalizability. Short duration of the study may not reflect long-term effects. Lack of blinding may introduce bias in outcome assessment.
Published in
Publication details and source links for this paper.
Huda K, Abdullah OB, Ahmed B, et al. Long term supplementation with Nigella sativa improves glucose homeostasis and enhances antioxidant defense system in type 2 diabetic patients treated with oral hypoglycemic drugs. PLOS ONE. 2015;10(2):e0113486. doi:10.1371/journal.pone.0113486
Fasting Plasma Glucose decreased by 22 mg/dL in the Nigella sativa group.
Glycosylated hemoglobin (HbA1c) decreased by 0.4% in the Nigella sativa group.
Total antioxidant capacity significantly increased in the Nigella sativa group.
Evidence network
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This study contributes evidence to Nigella sativa oil and Fasting Plasma Glucose (FPG), Glutathione (GSH), HbA1c, and 5 more.
This study contributes evidence to
Primary intervention
Nigella sativa oil
Primary outcomes
Evidence topics
Primary intervention
Primary outcomes
Intervention and outcome relationships this study adds to the evidence network.
Editorial context
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Evidence network role
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3
Related topics
8
Evidence pairs
1344
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Contributes evidence
Evidence topic
Contributes evidence
Evidence topic
Contributes evidence
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Primary evidence
Evidence topic
matched_outcome
Related evidence
Evidence topic
Save evidence
Core evidence
The primary outcomes reported in this study.
Nigella sativa oil → Fasting Plasma Glucose (FPG)
Nigella sativa oil → Fasting Plasma Glucose (FPG)
Nigella sativa oil → Natural Killer Cell Activity
Nigella sativa oil → Natural Killer Cell Activity
Nigella sativa oil → Superoxide Dismutase (SOD)
Nigella sativa oil → Superoxide Dismutase (SOD)
Nigella sativa oil → Thiobarbituric acid reactive substances in erythrocytes
Nigella sativa oil → Thiobarbituric acid reactive substances in erythrocytes
Nigella sativa oil → Total Antioxidant Capacity (TAC)
Nigella sativa oil → Total Antioxidant Capacity (TAC)
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Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on Nigella sativa oil and Fasting Glucose, Nigella sativa oil and Fasting Glucose.
This study contributes to the evidence on the following intervention-outcome relationships.
Supplements
Supplements
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1 results
1 results
1 results
1 results
1 results
Generated from the study's connected evidence using Evidence Intelligence™.
Nigella sativa oil appears to improve fasting plasma glucose (FPG).
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Fasting Plasma Glucose (FPG)
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Nigella sativa oil appears to lower HbA1c.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
HbA1c
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Nigella sativa oil appears to improve thiobarbituric acid reactive substances in erythrocytes.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Thiobarbituric acid reactive substances in erythrocytes
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Current evidence does not show a clear benefit of Nigella sativa oil for glutathione (GSH).
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Glutathione (GSH)
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | neutral | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
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