Last updated August 25, 2026
Key finding
There was a non-linear association between baseline fasting glucose and prediabetes remission at 1 year (P = 0.008).
This study analyzed the predictive value of novel OGTT metrics for prediabetes remission during lifestyle interventions in the PREVIEW trial, finding unclear effectiveness.
Quick read
The essential study design details in one scan.
EvidenceScore™
Moderate
Study type
RCTs
Follow-up
Long-Term (1–5 y)
Risk of bias
High Risk
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Plain-language summary
A plain-language read of the study’s main message and where it applies.
Study focus
This study analyzed the predictive value of novel OGTT metrics for prediabetes remission during lifestyle interventions in the PREVIEW trial, finding unclear effectiveness.
Understanding the factors that predict prediabetes remission is crucial for developing effective interventions. This study highlights the complexity of using novel OGTT metrics, suggesting that while lifestyle changes are important, the specific metrics may not reliably indicate remission outcomes.
Effectiveness of interventions remains unclear due to non-significant findings. Limited generalizability due to specific population characteristics. Potential confounding factors not accounted for in the analysis.
Published in
Publication details and source links for this paper.
Ruixin Z, Jie G, Gareth S, et al. Incremental predictive value of novel OGTT metrics for prediabetes remission during lifestyle intervention: a post-hoc analysis of the PREVIEW trial. Cardiovascular Diabetology. 2026;25:168. doi:10.1186/s12933-026-03186-0
Prediabetes remission at 1 year showed a non-linear association with baseline fasting glucose (P = 0.008).
At 2 years, inverse linear associations were observed, independent of 2-h glucose and HbA1c.
Higher baseline HbA1c was linked to a lower likelihood of remission at 3 years.
Evidence network
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This study contributes evidence to Moderate continuous exercise and 1-hour glucose level, 2-hour plasma glucose, Fasting Plasma Glucose (FPG), and 9 more.
This study contributes evidence to
Primary intervention
Moderate continuous exercise
Primary outcomes
Evidence topics
Primary intervention
Intervention and outcome relationships this study adds to the evidence network.
Editorial context
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Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
3
Related topics
12
Evidence pairs
796
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Evidence topic
Contributes evidence
Evidence topic
Contributes evidence
Evidence topic
Contributes evidence
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Primary evidence
Evidence relationship
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Evidence relationship
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Core evidence
The primary outcomes reported in this study.
Moderate continuous exercise → 1-hour glucose level
Moderate continuous exercise → 1-hour glucose level
Moderate continuous exercise → 2-hour plasma glucose
Moderate continuous exercise → 2-hour plasma glucose
Moderate continuous exercise → Fasting Plasma Glucose (FPG)
Moderate continuous exercise → Fasting Plasma Glucose (FPG)
Moderate continuous exercise → Glucose area under the curve (AUC)
Moderate continuous exercise → Glucose area under the curve (AUC)
Moderate continuous exercise → Maximum glucose
Moderate continuous exercise → Maximum glucose
Moderate continuous exercise → Maximum glucose excursion during OGTT
Moderate continuous exercise → Maximum glucose excursion during OGTT
Moderate continuous exercise → Minimum glucose
Moderate continuous exercise → Minimum glucose
Moderate continuous exercise → OGTT glucose AUC shape
Moderate continuous exercise → OGTT glucose AUC shape
Moderate continuous exercise → Prediabetes remission at 1 year
Moderate continuous exercise → Prediabetes remission at 1 year
Moderate continuous exercise → Prediabetes remission at 3 years
Moderate continuous exercise → Prediabetes remission at 3 years
Moderate continuous exercise → Time to glycemic target
Moderate continuous exercise → Time to glycemic target
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Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on Aerobic Exercise and Postprandial and OGTT Glucose, Aerobic Exercise and HbA1c.
This study contributes to the evidence on the following intervention-outcome relationships.
Physical Activity
Physical Activity
Curated evidence collections and hubs this study is part of.
All studies on Aerobic Exercise
Contributes to Aerobic Exercise evidence base.
All studies measuring HbA1c
Measures HbA1c as a key outcome.
All studies measuring Postprandial and OGTT Glucose
Measures Postprandial and OGTT Glucose as a key outcome.
Latest published studies
Published within the last 2 years.
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2 results
2 results
2 results
2 results
2 results
Generated from the study's connected evidence using Evidence Intelligence™.
Aerobic Exercise may improve Postprandial and OGTT Glucose.
ConsistencyScore™: Results are generally consistent across studies.
Ranked evidence signals
2-hour plasma glucose
EvidenceScore™ Moderate | EvidenceScore™ 69.0 | moderate positive | ConsistencyScore™ Mixed | 1 study
Glucose area under the curve (AUC)
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | neutral | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on 6 supporting studies with generally consistent results and a positive effect signal.
Limitations
Aerobic Exercise may improve HbA1c.
ConsistencyScore™: Results are generally consistent across studies.
Ranked evidence signals
HbA1c
EvidenceScore™ Moderate | EvidenceScore™ 69.0 | moderate positive | ConsistencyScore™ Mixed | 1 study
Why this answer: This answer is based on 7 supporting studies with generally consistent results and a positive effect signal.
Limitations
Aerobic Exercise appears to improve Fasting Glucose.
ConsistencyScore™: Results are consistent across studies.
Ranked evidence signals
Fasting Plasma Glucose (FPG)
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | neutral | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on 7 supporting studies with consistent results and a positive effect signal.
Limitations
Aerobic Exercise may improve CGM Time in Range.
ConsistencyScore™: Results are generally consistent across studies.
Ranked evidence signals
Time to glycemic target
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | neutral | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on 5 supporting studies with generally consistent results and a positive effect signal.
Limitations
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