Evidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 100
- Very Positive
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence TrackerResearch Summary
Analyzed using Evidence Intelligence™
Pentoxifylline improves kidney and heart health in diabetic patients
Last updated August 18, 2026
Key finding
Microalbuminuria changed −43.18 ± 52.13 mg/24 h in PTF-G at 12 months (p < 0.001).
Pentoxifylline added to standard therapy in adults with diabetic nephropathy.
Quick read
Study at a glance
The essential study design details in one scan.
EvidenceScore™
Moderate
Study type
RCTs
Follow-up
Long-Term (1–5 y)
Risk of bias
Some Concerns
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Plain-language summary
What this paper says
A plain-language read of the study’s main message and where it applies.
Study focus
Pentoxifylline added to standard therapy in adults with diabetic nephropathy.
Clinical relevance
This study evaluated Pentoxifylline added to standard therapy in adults with diabetic nephropathy.
Keep in mind
Limitations were not clearly described in the extracted text.
Published in
Journal Reference
Publication details and source links for this paper.
Oliva M, Marcela Á, Carmen P, et al. Pentoxifylline Treatment in Diabetic Nephropathy: A Randomized Controlled Trial. Medical Sciences. 2026;14(1):26. doi:10.3390/medsci14010026
Evidence network
How this study fits
Understand where this research contributes within the broader evidence network.
Evidence Context
This study contributes evidence to Pentoxifylline and Albuminuria, Estimated glomerular filtration rate, Left ventricular mass index.
This study contributes evidence to
Primary intervention
Pentoxifylline
Primary outcomes
- Albuminuria
- Estimated glomerular filtration rate
- Left ventricular mass index
Evidence topics
Primary intervention
Evidence relationships
Intervention and outcome relationships this study adds to the evidence network.
3
Evidence pairs
3
Relationships
1
Evidence topics
contributes_evidence
Editorial context
Why this study matters
See why this paper is useful beyond its individual results.
Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
Moderate contributionModerate confidenceNetwork score: 64
1
Related topics
3
Evidence pairs
93
Related studies
High relevance in at least one topic
Why it is useful
- Contributes to 3 evidence relationships
- Includes primary outcome data
- Linked to 1 direct semantic evidence topic
Topic contributions
Evidence topic
Contributes evidence
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Primary evidence
Evidence topic
Diabetic Kidney Disease
matched_intervention_and_outcome
Core evidence
Study findings
The primary outcomes reported in this study.
Estimated glomerular filtration rate
Pentoxifylline → Estimated glomerular filtration rate
Pentoxifylline → Estimated glomerular filtration rate
Evidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 25
- Negative
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence TrackerLeft ventricular mass index
Pentoxifylline → Left ventricular mass index
Pentoxifylline → Left ventricular mass index
Evidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 100
- Very Positive
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence TrackerEvidence Library
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Connected Evidence
Explore related studies, evidence collections, and research questions.
Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on Pentoxifylline and Kidney Function, Pentoxifylline and Kidney Function.
Related evidence relationships
Explore in Evidence ExplorerThis study contributes to the evidence on the following intervention-outcome relationships.
Medications
Pentoxifylline → Kidney Function
Medications
Evidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 100
- Very Positive
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
View evidenceMedications
Pentoxifylline → Kidney Function
Medications
Evidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 25
- Negative
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
View evidenceIncluded in these evidence collections
Curated evidence collections and hubs this study is part of.
Kidney Function Evidence Hub
All studies measuring Kidney Function
1 studies
outcome_hubMeasures Kidney Function as a key outcome.
Pentoxifylline Evidence Hub
All studies on Pentoxifylline
1 studies
intervention_hubContributes to Pentoxifylline evidence base.
Recent Diabetes Research
Latest published studies
recency_collection
Published within the last 2 years.
Explore more in Evidence Explorer
Jump to pre-filtered views in Evidence Explorer.
All studies on Pentoxifylline and Albuminuria
Intervention: PentoxifyllineOutcome: Albuminuria
1 results
All studies on Pentoxifylline and Estimated glomerular filtration rate
Intervention: PentoxifyllineOutcome: Estimated glomerular filtration rate
1 results
All studies on Pentoxifylline
Intervention: Pentoxifylline
1 results
All studies measuring Albuminuria
Outcome: Albuminuria
1 results
All studies measuring Estimated glomerular filtration rate
Outcome: Estimated glomerular filtration rate
1 results
Questions answered by this study
Generated from the study's connected evidence using Evidence Intelligence™.
Does Pentoxifylline improve albuminuria?
Emerging Evidence
Pentoxifylline appears to improve Albuminuria.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
- 1
Albuminuria
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
- Only one supporting study is available.
- Consistency cannot yet be determined.
- Population details are unavailable.
Does Pentoxifylline improve left ventricular mass index?
Emerging Evidence
Pentoxifylline appears to improve Left ventricular mass index.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
- 1
Left ventricular mass index
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
- Only one supporting study is available.
- Consistency cannot yet be determined.
- Population details are unavailable.
Does Pentoxifylline improve estimated glomerular filtration rate?
Emerging Evidence
Pentoxifylline may worsen Estimated glomerular filtration rate or be associated with harm.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
- 1
Estimated glomerular filtration rate
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | moderate negative | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
- Only one supporting study is available.
- Consistency cannot yet be determined.
- Population details are unavailable.
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