Last updated July 12, 2026
Key finding
HOMA-β increased from 32.48 ± 13.12 to 45.71 ± 25.18; p = 0.003
This study examined the effects of probiotic supplementation on β-cell function in individuals with type 2 diabetes, finding significant improvements in several metabolic parameters.
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EvidenceScore™
Moderate
Study type
RCTs
Follow-up
Short-Term (≤3 mo)
Risk of bias
Some Concerns
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Plain-language summary
A plain-language read of the study’s main message and where it applies.
Study focus
This study examined the effects of probiotic supplementation on β-cell function in individuals with type 2 diabetes, finding significant improvements in several metabolic parameters.
The findings are significant as they suggest that probiotic supplementation could be a beneficial adjunct therapy for individuals with type 2 diabetes, potentially leading to better management of blood sugar levels and improved overall metabolic health. This could help reduce the risk of diabetes-related complications and improve quality of life for patients.
Limited sample size may affect generalizability. Short duration of intervention may not capture long-term effects. Lack of detailed demographic data limits understanding of population diversity.
Published in
Publication details and source links for this paper.
Maryana S, Dmytro K, Iuliia K, Oleksandr K, Tetyana F, Nazarii K. The influence of probiotic supplementation vs. placebo on β-cell function in people with type 2 diabetes (T2D). Diabetes Therapy. 2023;14(11):1915-1931. doi:10.1007/s13300-023-01474-6
HOMA-β increased from 32.48 ± 13.12 to 45.71 ± 25.18; p = 0.003
Fasting plasma glucose decreased from 13.03 ± 3.46 to 10.66 ± 2.63 mmol/L; p < 0.001
HbA1c decreased from 8.86 ± 1.28 to 8.48 ± 1.22; p = 0.043
Evidence network
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This study contributes evidence to Probiotics and Fasting Plasma Glucose (FPG), HbA1c, Homeostatic Model Assessment of Beta-cell function (HOMA-β), and 1 more.
This study contributes evidence to
Primary intervention
Probiotics
Primary outcomes
Evidence topics
Primary intervention
Intervention and outcome relationships this study adds to the evidence network.
Editorial context
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Evidence network role
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Primary evidence
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Core evidence
The primary outcomes reported in this study.
Probiotics → Fasting Plasma Glucose (FPG)
Probiotics → Fasting Plasma Glucose (FPG)
Probiotics → Homeostatic Model Assessment of Beta-cell function (HOMA-β)
Probiotics → Homeostatic Model Assessment of Beta-cell function (HOMA-β)
Probiotics → Reduction of pro-inflammatory cytokine levels
Probiotics → Reduction of pro-inflammatory cytokine levels
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Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on Probiotics and Synbiotics and HbA1c, Probiotics and Synbiotics and Fasting Glucose.
This study contributes to the evidence on the following intervention-outcome relationships.
Supplements
Supplements
Curated evidence collections and hubs this study is part of.
All studies measuring HbA1c
Measures HbA1c as a key outcome.
All studies on Probiotics and Synbiotics
Contributes to Probiotics and Synbiotics evidence base.
All studies measuring Fasting Glucose
Measures Fasting Glucose as a key outcome.
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3 results
1 results
3 results
3 results
1 results
Generated from the study's connected evidence using Evidence Intelligence™.
Probiotics and Synbiotics may improve Fasting Glucose.
ConsistencyScore™: Results are generally consistent across studies.
Ranked evidence signals
Fasting Plasma Glucose (FPG)
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on 11 supporting studies with generally consistent results and a positive effect signal.
Limitations
Probiotics and Synbiotics appears to improve HbA1c.
ConsistencyScore™: Results are consistent across studies.
Ranked evidence signals
HbA1c
EvidenceScore™ Moderate | EvidenceScore™ 73.2 | moderate positive | ConsistencyScore™ Consistent | 1 study
Why this answer: This answer is based on 12 supporting studies with consistent results and a positive effect signal.
Limitations
Probiotics and Synbiotics appears to improve Beta-cell Function.
ConsistencyScore™: Results are consistent across studies.
Ranked evidence signals
Homeostatic Model Assessment of Beta-cell function (HOMA-β)
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a small number of supporting studies and should be interpreted cautiously.
Limitations
Probiotics appears to improve Reduction of pro-inflammatory cytokine levels.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Reduction of pro-inflammatory cytokine levels
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
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