Key finding
HbA1c decreased significantly from baseline.
This study investigated the impact of a multi-strain probiotic supplement on various health outcomes in individuals with Type 2 diabetes, finding significant reductions in HbA1c, fasting plasma glucose, and total cholesterol.
Evidence strength
Moderate confidence
Study type
RCTs
Follow-up
Medium-Term (3–12 mo)
Quick read
The essential study design details in one scan.
Population
Young Adult (19–39), Middle Aged (40-64), Male, Female, Asia-Pacific (APAC), with T2 Diabetes
Intervention
Multi-strain probiotic supplement (LactoLevure R)
Study type
RCTs
Follow-up
Medium-Term (3–12 mo)
Primary outcome
HbA1c
Comparator
Placebo Group
Plain-language summary
A plain-language read of the study's main message and where it applies.
Study focus
This study investigated the impact of a multi-strain probiotic supplement on various health outcomes in individuals with Type 2 diabetes, finding significant reductions in HbA1c, fasting plasma glucose, and total cholesterol.
The findings suggest that probiotic supplementation could be a beneficial adjunct therapy for managing Type 2 diabetes, potentially improving metabolic markers like blood sugar and cholesterol levels. This could lead to better overall health outcomes for patients, highlighting the importance of exploring dietary supplements in diabetes management.
Effectiveness of the intervention remains unclear due to limited evidence. No significant changes in gut microbiome diversity were observed. Study results may not be generalizable to all populations with Type 2 diabetes.
Published in
Publication details and source links for this paper.
Eva Z, Nikolas D, Charilaos D, et al. The Role of Probiotic Supplementation in Type 2 Diabetes Treatment: A Randomized Controlled Trial. Nutrients. 2023;15(21):4663. doi:10.3390/nu15214663
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HbA1c decreased by 0.73% (p=0.001)
Fasting plasma glucose decreased by 1.39 mmol/L (p=0.001)
Total cholesterol decreased by 0.28 mmol/L (p=0.012)
Evidence network
Understand where this research contributes within the broader evidence network.
This study contributes evidence to Multi-species synbiotic (12 probiotic strains + FOS prebiotic) and Adiposity indices, Fasting Plasma Glucose (FPG), Gut microbiota diversity, and 2 more.
This study contributes evidence to
Primary intervention
Multi-species synbiotic (12 probiotic strains + FOS prebiotic)
Primary outcomes
Intervention and outcome relationships this study adds to the evidence network.
Editorial context
See why this paper is useful beyond its individual results.
Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
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Related topics
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Evidence pairs
478
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Core evidence
The primary outcomes reported in this study.
Multi-species synbiotic (12 probiotic strains + FOS prebiotic) → Adiposity indices
Multi-species synbiotic (12 probiotic strains + FOS prebiotic) → Adiposity indices
Evidence profile
Multi-species synbiotic (12 probiotic strains + FOS prebiotic) → Fasting Plasma Glucose (FPG)
Multi-species synbiotic (12 probiotic strains + FOS prebiotic) → Fasting Plasma Glucose (FPG)
Evidence profile
Multi-species synbiotic (12 probiotic strains + FOS prebiotic) → Gut microbiota diversity
Multi-species synbiotic (12 probiotic strains + FOS prebiotic) → Gut microbiota diversity
Evidence profile
Multi-species synbiotic (12 probiotic strains + FOS prebiotic) → HbA1c
Multi-species synbiotic (12 probiotic strains + FOS prebiotic) → HbA1c
Evidence profile
Multi-species synbiotic (12 probiotic strains + FOS prebiotic) → Total cholesterol
Multi-species synbiotic (12 probiotic strains + FOS prebiotic) → Total cholesterol
Evidence profile
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Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on Probiotics and Synbiotics and HbA1c, Probiotics and Synbiotics and Fasting Glucose.
This study contributes to the evidence on the following intervention-outcome relationships.
Curated evidence collections and hubs this study is part of.
All studies measuring Fasting Glucose
Measures Fasting Glucose as a key outcome.
All studies measuring Adipokine and Angiogenic Markers
Measures Adipokine and Angiogenic Markers as a key outcome.
All studies measuring HbA1c
Measures HbA1c as a key outcome.
All studies on Probiotics and Synbiotics
Contributes to Probiotics and Synbiotics evidence base.
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2 results
3 results
2 results
2 results
3 results
Generated from the study's connected evidence using Evidence Intelligence™.
Probiotics and Synbiotics appears to improve HbA1c.
ConsensusScore™: Results are consistent across studies.
Ranked evidence signals
HbA1c
EvidenceScore™ Emerging | EvidenceScore™ 55.9 | strong positive | ConsensusScore™ Consistent | 1 study
Why this answer: This answer is based on 10 supporting studies with consistent results and a positive effect signal.
Limitations
Probiotics and Synbiotics may improve Fasting Glucose.
ConsensusScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Fasting Plasma Glucose (FPG)
EvidenceScore™ Emerging | EvidenceScore™ 54.3 | moderate positive | ConsensusScore™ Generally Consistent | 1 study
Why this answer: This answer is based on 9 supporting studies and existing graph evidence signals.
Limitations
Current evidence does not show a clear benefit of Probiotics and Synbiotics for Adipokine and Angiogenic Markers.
ConsensusScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Total cholesterol
EvidenceScore™ Emerging | EvidenceScore™ 47.1 | moderate positive | ConsensusScore™ Mixed | 1 study
Why this answer: This answer is based on 9 supporting studies and existing graph evidence signals.
Limitations
Current evidence does not show a clear benefit of Probiotics and Synbiotics for Gut Microbiota Diversity.
ConsensusScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Gut microbiota diversity
EvidenceScore™ Limited | EvidenceScore™ 34.2 | neutral | ConsensusScore™ Unclear | 1 study
Why this answer: This answer is based on a small number of supporting studies and should be interpreted cautiously.
Limitations
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