Last updated July 6, 2026
Key finding
FBS decreased significantly in the sitagliptin + metformin group compared to metformin alone (P = 0.030).
This study evaluated the effects of sitagliptin plus metformin therapy on metabolic profiles in patients with type 2 diabetes and NAFLD, finding significant improvements in various metabolic markers.
Quick read
The essential study design details in one scan.
EvidenceScore™
Moderate
Study type
RCTs
Follow-up
Medium-Term (3–12 mo)
Risk of bias
Some Concerns
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Plain-language summary
A plain-language read of the study’s main message and where it applies.
Study focus
This study evaluated the effects of sitagliptin plus metformin therapy on metabolic profiles in patients with type 2 diabetes and NAFLD, finding significant improvements in various metabolic markers.
The findings highlight the potential of combining sitagliptin with metformin to improve metabolic health in patients suffering from both type 2 diabetes and NAFLD. Given the rising prevalence of these conditions, effective treatment strategies are crucial for reducing long-term complications and improving patient outcomes.
The study's sample size may limit the generalizability of the findings. The duration of the intervention may not reflect long-term effects. Potential confounding factors were not fully controlled.
Published in
Publication details and source links for this paper.
Habib Y, Majid R, Niki K, Majid M, Narges ST. Sitagliptin Plus Metformin Therapy Improves Metabolic Profile in Patients with Type 2 Diabetes and NAFLD. Current Therapeutic Research, Clinical and Experimental. 2024;101:100764. doi:10.1016/j.curtheres.2024.100764
Fasting blood sugar decreased by 18 mg/dL in the sitagliptin + metformin group (P = 0.030).
Total cholesterol decreased by 58 mg/dL in the sitagliptin + metformin group (P = 0.017).
Triglycerides decreased by 93 mg/dL in the sitagliptin + metformin group (P = 0.008).
Evidence network
Understand where this research contributes within the broader evidence network.
This study contributes evidence to Dipeptidyl peptidase-4 inhibitors, Metformin and Alanine Aminotransferase (ALT), Fasting blood sugar (FBS), Glycemia risk index, and 2 more.
This study contributes evidence to
Primary intervention
Dipeptidyl peptidase-4 inhibitors
Primary outcomes
Primary intervention
Intervention and outcome relationships this study adds to the evidence network.
Editorial context
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Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
4
Related topics
10
Evidence pairs
664
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Contributes evidence
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Contributes evidence
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Contributes evidence
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Contributes evidence
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Primary evidence
Evidence relationship
Related evidence
Evidence relationship
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Evidence relationship
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Core evidence
The primary outcomes reported in this study.
Dipeptidyl peptidase-4 inhibitors → Alanine Aminotransferase (ALT)
Dipeptidyl peptidase-4 inhibitors → Alanine Aminotransferase (ALT)
Dipeptidyl peptidase-4 inhibitors → Fasting blood sugar (FBS)
Dipeptidyl peptidase-4 inhibitors → Fasting blood sugar (FBS)
Dipeptidyl peptidase-4 inhibitors → Glycemia risk index
Dipeptidyl peptidase-4 inhibitors → Glycemia risk index
Dipeptidyl peptidase-4 inhibitors → Total cholesterol
Dipeptidyl peptidase-4 inhibitors → Total cholesterol
Dipeptidyl peptidase-4 inhibitors → Triglycerides
Dipeptidyl peptidase-4 inhibitors → Triglycerides
Metformin → Alanine Aminotransferase (ALT)
Metformin → Alanine Aminotransferase (ALT)
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Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on Metformin Therapies and Fasting Glucose, DPP-4 Inhibitors and Fasting Glucose.
This study contributes to the evidence on the following intervention-outcome relationships.
Medications
Medications
Curated evidence collections and hubs this study is part of.
All studies measuring Fasting Glucose
Measures Fasting Glucose as a key outcome.
All studies on Metformin Therapies
Contributes to Metformin Therapies evidence base.
All studies on DPP-4 Inhibitors
Contributes to DPP-4 Inhibitors evidence base.
All studies measuring Adipokine and Angiogenic Markers
Measures Adipokine and Angiogenic Markers as a key outcome.
Latest published studies
Published within the last 2 years.
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4 results
2 results
4 results
2 results
4 results
Generated from the study's connected evidence using Evidence Intelligence™.
Metformin Therapies may improve Fasting Glucose.
ConsistencyScore™: Results are mixed and should be interpreted cautiously.
Ranked evidence signals
Fasting blood sugar (FBS)
EvidenceScore™ Strong | EvidenceScore™ 78.8 | moderate positive | ConsistencyScore™ Mixed | 1 study
Why this answer: This answer is cautious because the available studies report mixed findings.
Limitations
DPP-4 Inhibitors may improve CGM Time in Range.
ConsistencyScore™: Results are mixed and should be interpreted cautiously.
Ranked evidence signals
Glycemia risk index
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is cautious because the available studies report mixed findings.
Limitations
DPP-4 Inhibitors may improve Fasting Glucose.
ConsistencyScore™: Results are consistent across studies.
Ranked evidence signals
Fasting blood sugar (FBS)
EvidenceScore™ Moderate | EvidenceScore™ 69.0 | strong positive | ConsistencyScore™ Consistent | 1 study
Why this answer: This answer is based on 6 supporting studies with consistent results and a positive effect signal.
Limitations
Metformin Therapies may improve CGM Time in Range.
ConsistencyScore™: Results are generally consistent across studies.
Ranked evidence signals
Glycemia risk index
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | neutral | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on 3 supporting studies with generally consistent results and a positive effect signal.
Limitations
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