Last updated September 3, 2026
Key finding
The adjusted mean percent change from baseline in UACR for tirzepatide 5 mg compared with all pooled comparators was -19.3% (95% CI -25.5, -12.5).
The study evaluated the effects of tirzepatide on urine albumin-to-creatinine ratio in adults with type 2 diabetes and high cardiovascular risk, finding significant reductions across all doses.
Quick read
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EvidenceScore™
Moderate
Study type
RCTs
Follow-up
Short-Term (≤3 mo)
Risk of bias
High Risk
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Plain-language summary
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Study focus
The study evaluated the effects of tirzepatide on urine albumin-to-creatinine ratio in adults with type 2 diabetes and high cardiovascular risk, finding significant reductions across all doses.
This study is important as it highlights the potential of tirzepatide to improve kidney health in patients with type 2 diabetes, a group at high risk for kidney complications. Reducing urine albumin levels can indicate better kidney function and lower cardiovascular risk, making tirzepatide a valuable treatment option.
Effectiveness of tirzepatide remains unclear due to lack of statistical significance. No differences in eGFR were observed, limiting conclusions about kidney function. The study may have limited generalizability due to specific population characteristics.
Published in
Publication details and source links for this paper.
Ellen MA, Katherine RT, Imre P, et al. Tirzepatide Reduces Urine Albumin-to-Creatinine Ratio in Adults with Type 2 Diabetes and High Cardiovascular Risk. Diabetes Care. 2025;48(3):430-436. doi:10.2337/dc24-1773
Tirzepatide 5 mg reduced UACR by -19.3% (95% CI -25.5, -12.5).
Tirzepatide 10 mg reduced UACR by -22.0% (95% CI -28.1, -15.3).
Tirzepatide 15 mg reduced UACR by -26.3% (95% CI -32.0, -20.0).
Evidence network
Understand where this research contributes within the broader evidence network.
This study contributes evidence to Tirzepatide and Estimated glomerular filtration rate, Urinary albumin-to-creatinine ratio.
This study contributes evidence to
Primary intervention
Tirzepatide
Primary outcomes
Evidence topics
Primary intervention
Intervention and outcome relationships this study adds to the evidence network.
Editorial context
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Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
1
Related topics
2
Evidence pairs
70
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Contributes evidence
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Primary evidence
Evidence relationship
Related evidence
Evidence topic
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Intervention
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Core evidence
The primary outcomes reported in this study.
Tirzepatide → Estimated glomerular filtration rate
Tirzepatide → Estimated glomerular filtration rate
Tirzepatide → Urinary albumin-to-creatinine ratio
Tirzepatide → Urinary albumin-to-creatinine ratio
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Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on GLP-1 Receptor Agonists and Kidney Function, GLP-1 Receptor Agonists and Kidney Function.
This study contributes to the evidence on the following intervention-outcome relationships.
Medications
Medications
Curated evidence collections and hubs this study is part of.
All studies on GLP-1 Receptor Agonists
Contributes to GLP-1 Receptor Agonists evidence base.
All studies measuring Kidney Function
Measures Kidney Function as a key outcome.
Latest published studies
Published within the last 2 years.
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2 results
1 results
2 results
2 results
1 results
Generated from the study's connected evidence using Evidence Intelligence™.
GLP-1 Receptor Agonists may improve kidney function.
ConsistencyScore™: Results are mixed and should be interpreted cautiously.
Ranked evidence signals
Estimated glomerular filtration rate
EvidenceScore™ Moderate | EvidenceScore™ 69.0 | neutral | ConsistencyScore™ Consistent | 1 study
Urinary albumin-to-creatinine ratio
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is cautious because the available studies report mixed findings.
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