#1 HbA1c
Insulin Therapies → HbA1c
Evidence Intelligence™
- EvidenceScore™
- 88
- Strong
- ImpactScore™
- 72
- Positive
- ConsistencyScore™
- 63
- generally_consistent
Estudios de apoyo: Basado en 19 estudios
Explore evidenceMedications
Last updated: 12 de septiembre de 2026
Key takeaway
Medications has evidence across 10 diabetes-related outcomes, with strongest support for HbA1c, HbA1c and HbA1c.
Evidence status
Moderate ResearchEvidence Strength: 60/100
Related Evidence Topics
Evidence Intelligence™
Every evidence topic is generated from structured relationships across diabetes research, including topics, interventions, outcomes, and individual studies.
1,709
Evidence relationships
2,112
Studies reviewed
39
Outcomes evaluated
Strongest evidence area
HbA1c
Top Interventions
Showing grouped evidence. Expand in Evidence Explorer for detailed intervention-outcome pairs.Open Evidence Explorer
| Rank | Outcome group | EvidenceScore™ | ImpactScore™ | Consistency | Studies | Effectiveness | Action |
|---|---|---|---|---|---|---|---|
| #1 | HbA1c | 88/100Strong | 72/100Positive | 63/100generally_consistent | 19 | moderate_positive | Explore evidence |
| #2 | HbA1c | 87/100Strong | 90/100Very Positive | 95/100consistent | 45 | strong_positive | Explore evidence |
| #3 | HbA1c | 86/100Strong | 84/100Positive | 92/100consistent | 27 | moderate_positive | Explore evidence |
| #4 | Body Weight | 86/100Strong | 83/100Positive | 97/100consistent | 43 | moderate_positive | Explore evidence |
| #5 | HbA1c | 86/100Strong | 78/100Positive | 67/100generally_consistent | 9 | moderate_positive | Explore evidence |
| #6 | HbA1c | 86/100Strong | 94/100Very Positive | 100/100consistent | 8 | strong_positive | Explore evidence |
| #7 | Body Weight | 86/100Strong | 77/100Positive | 91/100consistent | 11 | moderate_positive | Explore evidence |
| #8 | HbA1c | 86/100Strong | 96/100Very Positive | 100/100consistent | 12 | strong_positive | Explore evidence |
| #9 | Fasting Glucose | 86/100Strong | 81/100Positive | 72/100generally_consistent | 18 | moderate_positive | Explore evidence |
| #10 | Insulin Resistance | 86/100Strong | 88/100Very Positive | 88/100consistent | 8 | strong_positive | Explore evidence |
#2 HbA1c
GLP-1 Receptor Agonists → HbA1c
Evidence Intelligence™
- EvidenceScore™
- 87
- Strong
- ImpactScore™
- 90
- Very Positive
- ConsistencyScore™
- 95
- consistent
Estudios de apoyo: Basado en 45 estudios
Explore evidence#3 HbA1c
SGLT2 Inhibitors → HbA1c
Evidence Intelligence™
- EvidenceScore™
- 86
- Strong
- ImpactScore™
- 84
- Positive
- ConsistencyScore™
- 92
- consistent
Estudios de apoyo: Basado en 27 estudios
Explore evidence#4 Body Weight
GLP-1 Receptor Agonists → Body Weight
Evidence Intelligence™
- EvidenceScore™
- 86
- Strong
- ImpactScore™
- 83
- Positive
- ConsistencyScore™
- 97
- consistent
Estudios de apoyo: Basado en 43 estudios
Explore evidence#5 HbA1c
Sulfonylureas → HbA1c
Evidence Intelligence™
- EvidenceScore™
- 86
- Strong
- ImpactScore™
- 78
- Positive
- ConsistencyScore™
- 67
- generally_consistent
Estudios de apoyo: Basado en 9 estudios
Explore evidence#6 HbA1c
Thiazolidinediones → HbA1c
Evidence Intelligence™
- EvidenceScore™
- 86
- Strong
- ImpactScore™
- 94
- Very Positive
- ConsistencyScore™
- 100
- consistent
Estudios de apoyo: Basado en 8 estudios
Explore evidence#7 Body Weight
SGLT2 Inhibitors → Body Weight
Evidence Intelligence™
- EvidenceScore™
- 86
- Strong
- ImpactScore™
- 77
- Positive
- ConsistencyScore™
- 91
- consistent
Estudios de apoyo: Basado en 11 estudios
Explore evidence#8 HbA1c
DPP-4 Inhibitors → HbA1c
Evidence Intelligence™
- EvidenceScore™
- 86
- Strong
- ImpactScore™
- 96
- Very Positive
- ConsistencyScore™
- 100
- consistent
Estudios de apoyo: Basado en 12 estudios
Explore evidence#9 Fasting Glucose
GLP-1 Receptor Agonists → Fasting Glucose
Evidence Intelligence™
- EvidenceScore™
- 86
- Strong
- ImpactScore™
- 81
- Positive
- ConsistencyScore™
- 72
- generally_consistent
Estudios de apoyo: Basado en 18 estudios
Explore evidence#10 Insulin Resistance
Insulin Therapies → Insulin Resistance
Evidence Intelligence™
- EvidenceScore™
- 86
- Strong
- ImpactScore™
- 88
- Very Positive
- ConsistencyScore™
- 88
- consistent
Estudios de apoyo: Basado en 8 estudios
Explore evidencePractical Questions
Relationships organized using the Dediabetes Evidence Intelligence™ framework.
Which outcomes have the strongest evidence for Medications?
evidence strengthStrong Evidence
Body weight and HbA1c have the strongest available evidence signals for Medications.
ConsistencyScore™: Results are consistent across studies.
Ranked evidence signals
- 1
HbA1c
EvidenceScore™ Strong | EvidenceScore™ 88.2 | strong positive | ConsistencyScore™ Consistent | 29 studies
- 2
Body weight
EvidenceScore™ Strong | EvidenceScore™ 85.8 | moderate positive | ConsistencyScore™ Consistent | 13 studies
Why this answer: This answer is based on 30 supporting studies with consistent results and a positive effect signal.
What outcomes does Medications appear to affect most often?
most studiedEmerging Evidence
HbA1c, Body weight, and Fasting Plasma Glucose (FPG) are among the most studied areas in relation to Medications.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Evidence caveat: The evidence includes both beneficial and harmful or worsening results.
Ranked evidence signals
- 1
HbA1c
EvidenceScore™ Strong | EvidenceScore™ 88.2 | strong positive | ConsistencyScore™ Consistent | 154 studies
- 2
Body weight
EvidenceScore™ Strong | EvidenceScore™ 85.8 | moderate positive | ConsistencyScore™ Consistent | 79 studies
- 3
Fasting Plasma Glucose (FPG)
EvidenceScore™ Strong | EvidenceScore™ 83.9 | moderate positive | ConsistencyScore™ Generally Consistent | 53 studies
Why this answer: This answer is cautious because the available studies report mixed findings.
Where are results mixed or inconsistent for Medications?
consistency issuesModerate Evidence
Results are mixed or unclear for Coefficient of variation, Time below range, and Time in range in relation to Medications.
ConsistencyScore™: Results are mixed and should be interpreted cautiously.
Evidence caveat: The evidence includes both beneficial and harmful or worsening results.
Ranked evidence signals
- 1
Body weight
EvidenceScore™ Strong | EvidenceScore™ 83.1 | moderate positive | ConsistencyScore™ Mixed | 11 studies
- 2
Glucose iAUC (OGTT)
EvidenceScore™ Strong | EvidenceScore™ 79.0 | moderate positive | ConsistencyScore™ Mixed | 6 studies
- 3
BMI
EvidenceScore™ Strong | EvidenceScore™ 79.0 | moderate positive | ConsistencyScore™ Mixed | 4 studies
Why this answer: This answer is cautious because the available studies report mixed findings.
Which outcomes need more research for Medications?
research gapsEmerging Evidence
Mean difference in post-meal glucose surges, Meibomian gland quality (MGQ), and Non-invasive tear breakup time (NITBUT) need more research in relation to Medications.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
- 1
Meibomian gland quality (MGQ)
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
- 2
Non-invasive tear breakup time (NITBUT)
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
- 3
Mean difference in post-meal glucose surges
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | neutral | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a small number of supporting studies and should be interpreted cautiously.
Limitations
- Only a small number of supporting studies are available.
How does HbA1c compare with Body weight for Medications?
compareStrong Evidence
Body weight and HbA1c have available evidence for Medications, but the comparison requires review of the underlying studies.
ConsistencyScore™: Results are consistent across studies.
Ranked evidence signals
- 1
HbA1c
EvidenceScore™ Strong | EvidenceScore™ 88.2 | strong positive | ConsistencyScore™ Consistent | 16 studies
- 2
Body weight
EvidenceScore™ Strong | EvidenceScore™ 85.8 | moderate positive | ConsistencyScore™ Consistent | 13 studies
Why this answer: This answer is based on 17 supporting studies with consistent results and a positive effect signal.
Outcomes Influenced by Medications
Outcomes most commonly studied in relation to medications interventions.
Diabetes Distress
EvidenceScore™ 69/100
Evidence related to Diabetes Distress.
2 Studies
HbA1c Reduction
EvidenceScore™ 65/100
Evidence related to lowering or improving HbA1c/A1C in diabetes management.
236 Studies
Cardiovascular Risk
EvidenceScore™ 63/100
Evidence related to cardiovascular risk, cardiovascular events, ASCVD risk, vascular function, functional capacity, and mortality outcomes in diabetes studies.
67 Studies
Weight Loss
EvidenceScore™ 62/100
Evidence related to body weight reduction, BMI improvement, waist circumference, and body composition changes.
211 Studies
Glycemic Control
EvidenceScore™ 62/100
Evidence related to blood glucose control, fasting glucose, postprandial glucose, glucose variability, and time in range.
160 Studies
Blood Pressure
EvidenceScore™ 62/100
Evidence related to Blood Pressure.
72 Studies
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Evidence Landscape
Evidence landscape
Each bubble represents an evidence relationship. Position shows effectiveness and EvidenceScoreâ„¢; size reflects study volume.
- Strong evidence
- Moderate evidence
- Limited evidence
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