Adding sitagliptin to insulin improves glycemic control in type 2 diabetesView research summary→
Highly relevant
Interventions:
Outcomes:
Strength:
Insulin Therapies for Diabetes: Evidence and Outcomes
Evidence on outcomes studied for Insulin Therapies
Evidence related to insulin therapies in diabetes studies.
8
Studies
31
Evidence Pairs
Moderate Evidence
Evidence Strength: 51/100
Supporting Studies
8
Research documents analyzed
Evidence Pairs
31
Intervention-outcome relationships
Latest Publication
May 2026
Avg. Evidence: 51/100
Evidence Snapshot
Qualitative overview of the evidence landscape
Low Confidence
Based on 8 studies, moderate evidence suggests Total daily insulin dose, Body Mass Index (BMI) change, Glycemia risk index are the strongest-supported outcomes for insulin therapies.
Practical Questions
What outcomes has Insulin Therapies been studied for?
outcomes studiedEmerging Evidence
Total daily insulin dose, Fasting Plasma Glucose (FPG), and Urinary albumin-to-creatinine ratio are among the most studied areas in relation to Insulin Therapies.
Consistency: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
- 1
Total daily insulin dose
Moderate | score 60.0 | strong positive | Consistent | 2 studies
- 2
24-Hour Urinary Protein (24hUpr)
Emerging | score 57.0 | strong positive | Unclear | 1 study
- 3
Endothelin-1 (ET-1)
Emerging | score 57.0 | strong positive | Unclear | 1 study
Why this answer: This answer is based on 8 supporting studies and existing graph evidence signals.
Limitations
- Consistency cannot yet be determined.
- Population details are unavailable.
Does Insulin Therapies improve HbA1c?
intervention outcome_effectEmerging Evidence
Insulin Therapies may improve HbA1c.
Consistency: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
- 1
HbA1c
Emerging | score 52.3 | weak positive | Generally Consistent | 7 studies
Why this answer: This answer is based on 7 supporting studies and existing graph evidence signals.
Limitations
- Consistency cannot yet be determined.
- Population details are unavailable.
Which outcomes have the strongest evidence for Insulin Therapies?
evidence strengthEmerging Evidence
Total daily insulin dose, Fasting Plasma Glucose (FPG), and Urinary albumin-to-creatinine ratio have the strongest available evidence signals for Insulin Therapies.
Consistency: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
- 1
Total daily insulin dose
Moderate | score 60.0 | strong positive | Consistent | 2 studies
- 2
24-Hour Urinary Protein (24hUpr)
Emerging | score 57.0 | strong positive | Unclear | 1 study
- 3
Endothelin-1 (ET-1)
Emerging | score 57.0 | strong positive | Unclear | 1 study
Why this answer: This answer is based on 3 supporting studies and existing graph evidence signals.
Limitations
- Consistency cannot yet be determined.
- Population details are unavailable.
Where does Insulin Therapies need more research?
research gapsEmerging Evidence
Total daily insulin dose, Fasting Plasma Glucose (FPG), and Urinary albumin-to-creatinine ratio need more research in relation to Insulin Therapies.
Consistency: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
- 1
Total daily insulin dose
Moderate | score 60.0 | strong positive | Consistent | 2 studies
- 2
24-Hour Urinary Protein (24hUpr)
Emerging | score 57.0 | strong positive | Unclear | 1 study
- 3
Endothelin-1 (ET-1)
Emerging | score 57.0 | strong positive | Unclear | 1 study
Why this answer: This answer is based on 3 supporting studies and existing graph evidence signals.
Limitations
- Consistency cannot yet be determined.
- Population details are unavailable.
How does Insulin Therapies compare across studied outcomes?
cross outcome_comparisonEmerging Evidence
Total daily insulin dose, Fasting Plasma Glucose (FPG), and Urinary albumin-to-creatinine ratio have available evidence for Insulin Therapies, but the comparison requires review of the underlying studies.
Consistency: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
- 1
Total daily insulin dose
Moderate | score 60.0 | strong positive | Consistent | 2 studies
- 2
24-Hour Urinary Protein (24hUpr)
Emerging | score 57.0 | strong positive | Unclear | 1 study
- 3
Endothelin-1 (ET-1)
Emerging | score 57.0 | strong positive | Unclear | 1 study
Why this answer: This answer is based on 3 supporting studies and existing graph evidence signals.
Limitations
- Consistency cannot yet be determined.
- Population details are unavailable.
Top outcomes affected
Outcome areas reported in the evidence summary.
Rank #1
Total daily insulin dose
Evidence strength: Moderate
Direction: strong positive
Consistency: Consistent
Studies: 2
Rank #2
24-Hour Urinary Protein (24hUpr)
Evidence strength: Emerging
Direction: strong positive
Consistency: Unclear
Studies: 1
Rank #3
Endothelin-1 (ET-1)
Evidence strength: Emerging
Direction: strong positive
Consistency: Unclear
Studies: 1
Strongest evidence relationships
Key patterns and insights identified across the research landscape
Strong positive signal
Total daily insulin dose
Across 2 studies, Insulin glargine/lixisenatide fixed-ratio combination (iGlarLixi) shows a consistent strong positive signal for Total daily insulin dose.
2 studies
Strength: 60.025/100
Strong positive signal
24-Hour Urinary Protein (24hUpr)
Across 1 study, Insulin therapy shows a strong positive signal for 24-Hour Urinary Protein (24hUpr).
1 studies
Strength: 56.95/100
Strong positive signal
Endothelin-1 (ET-1)
Across 1 study, Insulin therapy shows a strong positive signal for Endothelin-1 (ET-1).
1 studies
Strength: 56.95/100
Strong positive signal
Estimated glomerular filtration rate
Across 1 study, Insulin therapy shows a strong positive signal for Estimated glomerular filtration rate.
1 studies
Strength: 56.95/100
Strong positive signal
Fasting Plasma Glucose (FPG)
Across 1 study, Insulin therapy shows a strong positive signal for Fasting Plasma Glucose (FPG).
1 studies
Strength: 56.95/100
Studies evaluating Insulin Therapies
Studies connected to this intervention in the evidence record.
iGlarLixi improves glycemic control and reduces insulin injections in type 2 diabetesView research summary→
High quality
Outcomes:
Strength:
High-intensity interval exercise causes less blood sugar drop than moderate exercise in type 1 diabetesView research summary→
May 16, 2026
Recent
Interventions:
Outcomes:
Strength:
Semaglutide with Insulin Improves Diabetes Control and Kidney HealthView research summary→
High quality
Interventions:
Outcomes:
24-Hour Urinary Protein (24hUpr)Adverse events incidenceEndothelin-1 (ET-1)Estimated glomerular filtration rateFasting Plasma Glucose (FPG)Glucose iAUC (OGTT)HbA1cHomeostatic Model Assessment of Beta-cell function (HOMA-β)Insulin resistanceNitric Oxide (NO)Serum VEGFUrinary albumin-to-creatinine ratio
Strength:
Click outcomes and interventions to filter the archive when links are available.
Related Evidence Topics
Explore related evidence areas connected by shared studies, interventions, or outcomes.
Explore all Insulin Therapies evidence
Browse the complete evidence archive for this topic, including interventions, outcomes, and related research.
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