Evidence Intelligence™
- EvidenceScore™
- Strong
- Score 79 · Based on 3 studies
- ImpactScore™
- 50
- Neutral
- ConsistencyScore™
- 67
- generally_consistent
Estudios de apoyo: Basado en 3 estudios
Add to Evidence TrackerResumen de Investigación
Analyzed using Evidence Intelligence™
Intermittent fasting improves glycemic control in insulin-treated type 2 diabetes
Última actualización 4 de septiembre de 2026
Key finding
HbA1c decreased by 7.3 ± 12.0 mmol/mol in the IF group compared to an increase of 0.1 ± 6.1 mmol/mol in the control group.
The INTERFAST-2 study evaluated the effects of intermittent fasting on individuals with insulin-treated type 2 diabetes, finding significant improvements in glycemic control and weight loss.
Quick read
Study at a glance
The essential study design details in one scan.
EvidenceScore™
Moderate
Study type
RCTs
Follow-up
Extended (5–20+ y)
Risk of bias
Some Concerns
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Plain-language summary
What this paper says
A plain-language read of the study’s main message and where it applies.
Study focus
The INTERFAST-2 study evaluated the effects of intermittent fasting on individuals with insulin-treated type 2 diabetes, finding significant improvements in glycemic control and weight loss.
Clinical relevance
These findings suggest that intermittent fasting could be a beneficial dietary strategy for managing type 2 diabetes, potentially leading to better glycemic control and reduced medication needs. This approach may help patients achieve weight loss and improve their overall health, which is crucial in diabetes management.
Keep in mind
Limited sample size may affect generalizability. Short duration of the study may not capture long-term effects. Lack of diversity in the participant population.
Published in
Referencia de la Revista
Publication details and source links for this paper.
Anna O, Norbert JT, Peter NP, et al. Intermittent fasting in subjects with insulin-treated type 2 diabetes mellitus (INTERFAST-2). Diabetes Care. 2023;46(2):463-468. doi:10.2337/dc22-1622
Efectos Principales
HbA1c decreased by 7.3 ± 12.0 mmol/mol in the IF group (p=0.012).
Weight decreased by 4.77 ± 4.99 kg in the IF group (p=0.001).
Total daily insulin dose reduced by 9 ± 10 IU in the IF group (p=0.008).
Evidence network
How this study fits
Understand where this research contributes within the broader evidence network.
Evidence Context
This study contributes evidence to Control Group Usual Activity, Intermittent Fasting (IF) and HbA1c, Body fat mass, Change in self-reported perceived health status, and 5 more.
This study contributes evidence to
Primary intervention
Control Group Usual Activity
Primary outcomes
- HbA1c
- Body fat mass
- Change in self-reported perceived health status
Primary intervention
Evidence relationships
Intervention and outcome relationships this study adds to the evidence network.
9
Evidence pairs
9
Relationships
6
Evidence topics
contributes_evidence
Editorial context
Why this study matters
See why this paper is useful beyond its individual results.
Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
Moderate contributionModerate confidenceNetwork score: 68
6
Related topics
9
Evidence pairs
2131
Related studies
High relevance in at least one topic
Why it is useful
- Contributes to 9 evidence relationships
- Includes primary outcome data
- Linked to 6 direct semantic evidence topics
Topic contributions
Evidence topic
Contributes evidence
Evidence topic
Contributes evidence
Evidence topic
Contributes evidence
Evidence topic
Contributes evidence
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Evidencia principal
Tema de evidencia
Dietary Patterns
matched_intervention_and_outcome
Evidencia relacionada
Tema de evidencia
CGM Time in Range
Guardar evidencia
Core evidence
Study findings
The primary outcomes reported in this study.
Evidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 100
- Very Positive
- ConsistencyScore™
- unclear
- Not enough independent studies
Estudios de apoyo: Basado en 1 estudio
Add to Evidence TrackerChange in self-reported perceived health status
Intermittent Fasting (IF) → Change in self-reported perceived health status
Intermittent Fasting (IF) → Change in self-reported perceived health status
Evidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 100
- Very Positive
- ConsistencyScore™
- unclear
- Not enough independent studies
Estudios de apoyo: Basado en 1 estudio
Add to Evidence TrackerComposite endpoint achievement
Intermittent Fasting (IF) → Composite endpoint achievement
Intermittent Fasting (IF) → Composite endpoint achievement
Evidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 100
- Very Positive
- ConsistencyScore™
- unclear
- Not enough independent studies
Estudios de apoyo: Basado en 1 estudio
Add to Evidence TrackerEvidence Intelligence™
- EvidenceScore™
- 84
- Strong
- ImpactScore™
- 100
- Very Positive
- ConsistencyScore™
- 100
- consistent
Estudios de apoyo: Basado en 5 estudios
Add to Evidence TrackerTime above range
Intermittent Fasting (IF) → Time above range
Intermittent Fasting (IF) → Time above range
Evidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 100
- Very Positive
- ConsistencyScore™
- unclear
- Not enough independent studies
Estudios de apoyo: Basado en 1 estudio
Add to Evidence TrackerEvidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 100
- Very Positive
- ConsistencyScore™
- unclear
- Not enough independent studies
Estudios de apoyo: Basado en 1 estudio
Add to Evidence TrackerTotal daily insulin dose
Intermittent Fasting (IF) → Total daily insulin dose
Intermittent Fasting (IF) → Total daily insulin dose
Evidence Intelligence™
- EvidenceScore™
- Moderate
- Score 69 · Based on 2 studies
- ImpactScore™
- 75
- Positive
- ConsistencyScore™
- 100
- consistent
Estudios de apoyo: Basado en 2 estudios
Add to Evidence TrackerEvidence Intelligence™
- EvidenceScore™
- Strong
- Score 79 · Based on 3 studies
- ImpactScore™
- 100
- Very Positive
- ConsistencyScore™
- 100
- consistent
Estudios de apoyo: Basado en 3 estudios
Add to Evidence TrackerEvidence Library
Build your evidence library
Save research, organize studies, and quickly find important evidence again.
La Evidencia Sugiere
- 8 participants in the IF group achieved the composite end point (p=0.001).
- Fat mass decreased by 3.5 ± 3.3 kg in the IF group (p=0.001).
- Mean time in range improved to 68.0 ± 20.2% in the IF group.
A quién se aplica
- Adults with insulin-treated type 2 diabetes.
- Individuals seeking alternative dietary strategies for diabetes management.
Tener en Cuenta
- Results may not apply to non-insulin-treated diabetes patients.
- Further research is needed to confirm long-term effects.
- Individual responses to intermittent fasting can vary.
Entre Líneas
- Limited sample size may affect generalizability.
- Short duration of the study may not capture long-term effects.
- Lack of diversity in the participant population.
Evidence Library
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Connected Evidence
Explore related studies, evidence collections, and research questions.
Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on Intermittent Fasting (IF) and HbA1c, Control Group Usual Activity and HbA1c.
Relaciones de evidencia relacionadas
Explore in Evidence ExplorerThis study contributes to the evidence on the following intervention-outcome relationships.
Diet and Nutrition
Intermittent Fasting (IF) → HbA1c
Diet and Nutrition
Evidence Intelligence™
- EvidenceScore™
- 84
- Strong
- ImpactScore™
- 100
- Very Positive
- ConsistencyScore™
- 100
- consistent
Estudios de apoyo: Basado en 5 estudios
View evidencePhysical Activity
Control Group Usual Activity → HbA1c
Physical Activity
Evidence Intelligence™
- EvidenceScore™
- Strong
- Score 79 · Based on 3 studies
- ImpactScore™
- 50
- Neutral
- ConsistencyScore™
- 67
- generally_consistent
Estudios de apoyo: Basado en 3 estudios
View evidenceDiet and Nutrition
Intermittent Fasting (IF) → Body Weight
Diet and Nutrition
Evidence Intelligence™
- EvidenceScore™
- Strong
- Score 79 · Based on 3 studies
- ImpactScore™
- 100
- Very Positive
- ConsistencyScore™
- 100
- consistent
Estudios de apoyo: Basado en 3 estudios
View evidenceIncluido en estas colecciones de evidencia
Curated evidence collections and hubs this study is part of.
HbA1c Evidence Hub
All studies measuring HbA1c
5 studies
outcome_hubMeasures HbA1c as a key outcome.
Intermittent Fasting (IF) Evidence Hub
All studies on Intermittent Fasting (IF)
5 studies
intervention_hubContributes to Intermittent Fasting (IF) evidence base.
Body Weight Evidence Hub
All studies measuring Body Weight
3 studies
outcome_hubMeasures Body Weight as a key outcome.
Control Group Usual Activity Evidence Hub
All studies on Control Group Usual Activity
3 studies
intervention_hubContributes to Control Group Usual Activity evidence base.
Explora más en Evidence Explorer
Jump to pre-filtered views in Evidence Explorer.
All studies on Intermittent Fasting (IF) and HbA1c
Intervention: Intermittent Fasting (IF)Outcome: HbA1c
5 results
All studies on Control Group Usual Activity and HbA1c
Intervention: Control Group Usual ActivityOutcome: HbA1c
3 results
All studies on Intermittent Fasting (IF)
Intervention: Intermittent Fasting (IF)
5 results
All studies on Control Group Usual Activity
Intervention: Control Group Usual Activity
3 results
All studies measuring HbA1c
Outcome: HbA1c
5 results
Questions answered by this study
Generated from the study's connected evidence using Evidence Intelligence™.
Does Intermittent Fasting (IF) lower HbA1c?
Strong Evidence
Intermittent Fasting (IF) appears to lower HbA1c.
ConsistencyScore™: Results are consistent across studies.
Ranked evidence signals
- 1
HbA1c
EvidenceScore™ Strong | EvidenceScore™ 83.8 | strong positive | ConsistencyScore™ Consistent | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
- Only one supporting study is available.
Does Intermittent Fasting (IF) improve weight change?
Strong Evidence
Intermittent Fasting (IF) appears to improve weight change.
ConsistencyScore™: Results are consistent across studies.
Ranked evidence signals
- 1
Weight change
EvidenceScore™ Strong | EvidenceScore™ 79.0 | strong positive | ConsistencyScore™ Consistent | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
- Only one supporting study is available.
Does Control Group Usual Activity lower HbA1c?
Strong Evidence
Current evidence does not show a clear benefit of Control Group Usual Activity for HbA1c.
ConsistencyScore™: Results are generally consistent across studies.
Ranked evidence signals
- 1
HbA1c
EvidenceScore™ Strong | EvidenceScore™ 79.0 | neutral | ConsistencyScore™ Generally Consistent | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
- Only one supporting study is available.
Does Intermittent Fasting (IF) improve total daily insulin dose?
Moderate Evidence
Intermittent Fasting (IF) may improve total daily insulin dose.
ConsistencyScore™: Results are consistent across studies.
Ranked evidence signals
- 1
Total daily insulin dose
EvidenceScore™ Moderate | EvidenceScore™ 69.0 | moderate positive | ConsistencyScore™ Consistent | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
- Only one supporting study is available.
Next steps
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Evidence topics
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Related research
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Video education improves dietary compliance for diabetesStructured exercise improves metabolic health in prediabetic adultsAdding medications improves blood sugar control in diabetes patients.Dietary interventions improve glycemic control in pre-diabetic patientsIntermittent fasting improves glycemic control.
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