Evidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 50
- Neutral
- ConsistencyScore™
- unclear
- Not enough independent studies
Estudios de apoyo: Basado en 1 estudio
Add to Evidence TrackerResumen de Investigación
Analyzed using Evidence Intelligence™
Ketoanalogues may slow eGFR decline in type 2 diabetes patients
Última actualización 12 de septiembre de 2026
Key finding
The decrease in eGFR CysC from the baseline was -4.29 ± 0.96 mL/min in LPD + KA and -8.54 ± 2.19 mL/min in LPD (p = 0.012).
This study investigated the effects of a low-protein diet supplemented with ketoanalogues on kidney function in patients with type 2 diabetes, finding a slower decline in eGFR compared to a standard low-protein diet.
Quick read
Study at a glance
The essential study design details in one scan.
EvidenceScore™
Moderate
Study type
RCTs
Follow-up
Extended (5–20+ y)
Risk of bias
Some Concerns
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Plain-language summary
What this paper says
A plain-language read of the study’s main message and where it applies.
Study focus
This study investigated the effects of a low-protein diet supplemented with ketoanalogues on kidney function in patients with type 2 diabetes, finding a slower decline in eGFR compared to a standard low-protein diet.
Clinical relevance
The findings are significant for managing kidney health in patients with type 2 diabetes, a population at high risk for kidney disease. Slowing the decline in kidney function can reduce the need for dialysis and improve overall patient outcomes, making ketoanalogues a valuable dietary intervention.
Keep in mind
The study did not assess long-term outcomes beyond the intervention period. Sample size and demographic diversity may limit generalizability. The effects of ketoanalogues on other health parameters were not evaluated.
Published in
Referencia de la Revista
Publication details and source links for this paper.
Ramón P, Marcela &, Julia N, et al. The Use of Ketoanalogues Slows the Decline in eGFR in Patients with Type 2 Diabetes. Nutrients. 2026;18(16):2630. doi:10.3390/nu18162630
Efectos Principales
The decline in eGFR Cystatin C was -4.29 ± 0.96 mL/min in the LPD + KA group compared to -8.54 ± 2.19 mL/min in the LPD group (p = 0.012).
No differences in dialysis requirement were observed between the two groups.
Nutritional status, hospitalization rates, morbidity, and mortality showed no significant differences between the groups.
Evidence network
How this study fits
Understand where this research contributes within the broader evidence network.
Evidence Context
This study contributes evidence to Low-protein diet and All-cause mortality, Composite multimorbidity score, Dialysis requirement, and 3 more.
This study contributes evidence to
Primary intervention
Low-protein diet
Primary outcomes
- All-cause mortality
- Composite multimorbidity score
- Dialysis requirement
Evidence topics
Primary intervention
Evidence relationships
Intervention and outcome relationships this study adds to the evidence network.
6
Evidence pairs
6
Relationships
1
Evidence topics
contributes_evidence
Editorial context
Why this study matters
See why this paper is useful beyond its individual results.
Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
Moderate contributionModerate confidenceNetwork score: 63
1
Related topics
6
Evidence pairs
56
Related studies
High relevance in at least one topic
Why it is useful
- Contributes to 6 evidence relationships
- Includes primary outcome data
- Linked to 1 direct semantic evidence topic
Topic contributions
Evidence topic
Contributes evidence
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Evidencia principal
Tema de evidencia
Cardiovascular Risk
matched_outcome
Core evidence
Study findings
The primary outcomes reported in this study.
Composite multimorbidity score
Low-protein diet → Composite multimorbidity score
Low-protein diet → Composite multimorbidity score
Evidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 50
- Neutral
- ConsistencyScore™
- unclear
- Not enough independent studies
Estudios de apoyo: Basado en 1 estudio
Add to Evidence TrackerEvidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 50
- Neutral
- ConsistencyScore™
- unclear
- Not enough independent studies
Estudios de apoyo: Basado en 1 estudio
Add to Evidence TrackerEstimated glomerular filtration rate
Low-protein diet → Estimated glomerular filtration rate
Low-protein diet → Estimated glomerular filtration rate
Evidence Intelligence™
- EvidenceScore™
- Moderate
- Score 69 · Based on 2 studies
- ImpactScore™
- 100
- Very Positive
- ConsistencyScore™
- 100
- consistent
Estudios de apoyo: Basado en 2 estudios
Add to Evidence TrackerEvidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 50
- Neutral
- ConsistencyScore™
- unclear
- Not enough independent studies
Estudios de apoyo: Basado en 1 estudio
Add to Evidence TrackerEvidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 50
- Neutral
- ConsistencyScore™
- unclear
- Not enough independent studies
Estudios de apoyo: Basado en 1 estudio
Add to Evidence TrackerEvidence Library
Build your evidence library
Save research, organize studies, and quickly find important evidence again.
La Evidencia Sugiere
- Ketoanalogues reduced the decline in eGFR by 4.25 mL/min compared to standard low-protein diet.
- No differences in dialysis needs were found between the two dietary approaches.
- Nutritional status remained stable across both groups.
A quién se aplica
- Adults with type 2 diabetes.
- Patients at risk of kidney disease due to diabetes.
Tener en Cuenta
- The study's findings are based on a specific population and may not apply to all diabetes patients.
- Further research is needed to confirm long-term benefits of ketoanalogues.
- The study did not explore the impact of ketoanalogues on other health outcomes.
Entre Líneas
- The study did not assess long-term outcomes beyond the intervention period.
- Sample size and demographic diversity may limit generalizability.
- The effects of ketoanalogues on other health parameters were not evaluated.
Evidence Library
Build your evidence library
Save research, organize studies, and quickly find important evidence again.
Connected Evidence
Explore related studies, evidence collections, and research questions.
Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on Low-protein diet and Kidney Function, Low-protein diet and Cardiovascular Outcomes.
Relaciones de evidencia relacionadas
Explore in Evidence ExplorerThis study contributes to the evidence on the following intervention-outcome relationships.
Diet and Nutrition
Low-protein diet → Kidney Function
Diet and Nutrition
Evidence Intelligence™
- EvidenceScore™
- Moderate
- Score 69 · Based on 2 studies
- ImpactScore™
- 100
- Very Positive
- ConsistencyScore™
- 100
- consistent
Estudios de apoyo: Basado en 2 estudios
View evidenceDiet and Nutrition
Low-protein diet → Cardiovascular Outcomes
Diet and Nutrition
Evidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 50
- Neutral
- ConsistencyScore™
- unclear
- Not enough independent studies
Estudios de apoyo: Basado en 1 estudio
View evidenceIncluido en estas colecciones de evidencia
Curated evidence collections and hubs this study is part of.
Kidney Function Evidence Hub
All studies measuring Kidney Function
2 studies
outcome_hubMeasures Kidney Function as a key outcome.
Low-protein diet Evidence Hub
All studies on Low-protein diet
2 studies
intervention_hubContributes to Low-protein diet evidence base.
Cardiovascular Outcomes Evidence Hub
All studies measuring Cardiovascular Outcomes
1 studies
outcome_hubMeasures Cardiovascular Outcomes as a key outcome.
Recent Diabetes Research
Latest published studies
recency_collection
Published within the last 2 years.
Explora más en Evidence Explorer
Jump to pre-filtered views in Evidence Explorer.
All studies on Low-protein diet and Estimated glomerular filtration rate
Intervention: Low-protein dietOutcome: Estimated glomerular filtration rate
2 results
All studies on Low-protein diet and All-cause mortality
Intervention: Low-protein dietOutcome: All-cause mortality
1 results
All studies on Low-protein diet
Intervention: Low-protein diet
2 results
All studies measuring Estimated glomerular filtration rate
Outcome: Estimated glomerular filtration rate
2 results
All studies measuring All-cause mortality
Outcome: All-cause mortality
1 results
Questions answered by this study
Generated from the study's connected evidence using Evidence Intelligence™.
Does Low-protein diet improve estimated glomerular filtration rate?
Moderate Evidence
Low-protein diet appears to improve estimated glomerular filtration rate.
ConsistencyScore™: Results are consistent across studies.
Ranked evidence signals
- 1
Estimated glomerular filtration rate
EvidenceScore™ Moderate | EvidenceScore™ 69.0 | strong positive | ConsistencyScore™ Consistent | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
- Only one supporting study is available.
Does Low-protein diet improve all-cause mortality?
Emerging Evidence
Current evidence does not show a clear benefit of Low-protein diet for all-cause mortality.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
- 1
All-cause mortality
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | neutral | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
- Only one supporting study is available.
Does Low-protein diet improve composite multimorbidity score?
Emerging Evidence
Current evidence does not show a clear benefit of Low-protein diet for composite multimorbidity score.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
- 1
Composite multimorbidity score
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | neutral | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
- Only one supporting study is available.
Does Low-protein diet improve dialysis requirement?
Emerging Evidence
Current evidence does not show a clear benefit of Low-protein diet for dialysis requirement.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
- 1
Dialysis requirement
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | neutral | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
- Only one supporting study is available.
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