Última actualización 11 de julio de 2026
Key finding
No significant RMR differences were found between groups at baseline and post-intervention.
This study investigated the effects of circuit resistance training, a vegetarian/Mediterranean diet, and empagliflozin on resting metabolic rate in older adults with type 2 diabetes, finding no significant differences in resting metabolic rate across groups.
Quick read
The essential study design details in one scan.
EvidenceScore™
Moderate
Study type
RCTs
Follow-up
Medium-Term (3–12 mo)
Risk of bias
Some Concerns
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Plain-language summary
A plain-language read of the study’s main message and where it applies.
Study focus
This study investigated the effects of circuit resistance training, a vegetarian/Mediterranean diet, and empagliflozin on resting metabolic rate in older adults with type 2 diabetes, finding no significant differences in resting metabolic rate across groups.
Understanding how different interventions affect metabolic rates is crucial for managing type 2 diabetes in older adults. While this study did not find significant changes in resting metabolic rate, it highlights the importance of exploring various lifestyle and medication strategies to optimize health outcomes in this population.
The study did not find significant changes in the primary outcome, limiting the effectiveness conclusions. Results may not be generalizable to younger populations or those without diabetes. Potential confounding factors were not fully controlled, which may affect the findings.
Published in
Publication details and source links for this paper.
Assaf B, Roy E, Ofer K, et al. Effects of Circuit Resistance Training, Vegetarian/Mediterranean Diet, and Empagliflozin on Resting Metabolic Rate in Older Adults with Type 2 Diabetes. Heliyon. 2025;11(2):e41593. doi:10.1016/j.heliyon.2024.e41593
No significant differences in resting metabolic rate were found between intervention groups at baseline and post-intervention.
Systolic blood pressure showed a correlation with resting metabolic rate changes (r = 0.24).
Fat percentage was negatively correlated with resting metabolic rate changes (r = -0.27).
Leg strength positively correlated with resting metabolic rate changes (r = 0.29).
Evidence network
Understand where this research contributes within the broader evidence network.
This study contributes evidence to Empagliflozin, Mediterranean diet, Resistance training and Changes in Resting Metabolic Rate, Body fat percentage reduction, Correlation of Sleep Hours with Changes in Resting Metabolic Rate, and 2 more.
This study contributes evidence to
Primary intervention
Empagliflozin
Primary outcomes
Evidence topics
Primary intervention
Intervention and outcome relationships this study adds to the evidence network.
Editorial context
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Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
2
Related topics
7
Evidence pairs
169
Related studies
Evidence topic
Contributes evidence
Evidence topic
Contributes evidence
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Evidencia principal
Tema de evidencia
matched_intervention_and_outcome
Evidencia relacionada
Tema de evidencia
Guardar evidencia
Core evidence
The primary outcomes reported in this study.
Empagliflozin → Changes in Resting Metabolic Rate
Empagliflozin → Changes in Resting Metabolic Rate
Mediterranean diet → Changes in Resting Metabolic Rate
Mediterranean diet → Changes in Resting Metabolic Rate
Resistance training → Body fat percentage reduction
Resistance training → Body fat percentage reduction
Resistance training → Changes in Resting Metabolic Rate
Resistance training → Changes in Resting Metabolic Rate
Resistance training → Correlation of Sleep Hours with Changes in Resting Metabolic Rate
Resistance training → Correlation of Sleep Hours with Changes in Resting Metabolic Rate
Resistance training → Leg Strength Correlation with Resting Metabolic Rate Changes
Resistance training → Leg Strength Correlation with Resting Metabolic Rate Changes
Resistance training → Systolic blood pressure
Resistance training → Systolic blood pressure
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Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on SGLT2 Inhibitors and Changes in Resting Metabolic Rate, Mediterranean diet and Changes in Resting Metabolic Rate.
This study contributes to the evidence on the following intervention-outcome relationships.
Diet and Nutrition
Physical Activity
Curated evidence collections and hubs this study is part of.
All studies measuring Blood Pressure
Measures Blood Pressure as a key outcome.
All studies measuring Changes in Resting Metabolic Rate
Measures Changes in Resting Metabolic Rate as a key outcome.
All studies on Mediterranean diet
Contributes to Mediterranean diet evidence base.
All studies on Resistance training
Contributes to Resistance training evidence base.
All studies on SGLT2 Inhibitors
Contributes to SGLT2 Inhibitors evidence base.
Jump to pre-filtered views in Evidence Explorer.
1 results
1 results
1 results
1 results
1 results
Generated from the study's connected evidence using Evidence Intelligence™.
Current evidence does not show a clear benefit of Empagliflozin for Changes in Resting Metabolic Rate.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Changes in Resting Metabolic Rate
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | neutral | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Current evidence does not show a clear benefit of Mediterranean diet for Changes in Resting Metabolic Rate.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Changes in Resting Metabolic Rate
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | neutral | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Current evidence does not show a clear benefit of Resistance training for Body fat percentage reduction.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Body fat percentage reduction
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | neutral | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Current evidence does not show a clear benefit of Resistance training for Changes in Resting Metabolic Rate.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Changes in Resting Metabolic Rate
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | neutral | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
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