Resumen de Investigación
Analyzed using Evidence Intelligence™

Telehealth SMS improves statin adherence

Powered by the Dediabetes Evidence Intelligence™ framework

Última actualización 6 de julio de 2026

Key finding

The intervention group demonstrated a significant improvement in MARS-5 scores (24.23 ± 1.34) compared to the control group (19.00 ± 3.20) (P = 0.000).

Telehealth through SMS reminders significantly improved statin adherence and reduced cholesterol levels in patients with diabetes.

Quick read

Study at a glance

The essential study design details in one scan.

EvidenceScore™

Moderate

Study type

RCTs

Follow-up

Medium-Term (3–12 mo)

Risk of bias

Some Concerns

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Plain-language summary

What this paper says

A plain-language read of the study's main message and where it applies.

Study focus

Telehealth through SMS reminders significantly improved statin adherence and reduced cholesterol levels in patients with diabetes.

Clinical relevance

Improving medication adherence is crucial for managing diabetes and preventing cardiovascular diseases. The findings suggest that simple, low-cost interventions like SMS reminders can lead to better health outcomes for patients, potentially reducing the burden of chronic diseases and healthcare costs.

Keep in mind

The study did not measure long-term adherence beyond the intervention period. Results may not be generalizable to all diabetic populations. The impact of SMS reminders on clinical outcomes like heart events was not significant.

Published in

Referencia de la Revista

Publication details and source links for this paper.

Amna AD, Neama MM, Mohammad HA, Eman MH. Telehealth through SMS improves statin adherence in patients with diabetes. BMC Health Services Research. 2025;25:1150. doi:10.1186/s12913-025-13295-3

View DOIView on PubMedView on PMC

Efectos Principales

Adherence rate improved significantly in the intervention group (MARS-5: 24.23 ± 1.34 vs. 19.00 ± 3.20, P = 0.000).

Pill count adherence increased significantly in the intervention group (99.07 ± 2.75 vs. 90.41 ± 7.68, P = 0.000).

Total cholesterol decreased significantly in the intervention group (135.26 ± 52.62 vs. 186.85 ± 54.89, P = 0.000).

LDL-c levels decreased significantly in the intervention group (71.09 ± 46.66 vs. 108.42 ± 51.93, P = 0.001).

Evidence network

How this study fits

Understand where this research contributes within the broader evidence network.

Evidence Context

This study contributes evidence to SMS text messaging behavioral intervention for health promotion and Adherence rate (MARS-5), All-cause mortality, Cardiovascular events, and 3 more.

This study contributes evidence to

Intervention

SMS text messaging behavioral intervention for health promotion

Outcome

Adherence rate (MARS-5)

Evidence topic

Cardiovascular Risk

Primary intervention

SMS text messaging behavioral intervention for health promotion

Primary outcomes

  • Adherence rate (MARS-5)
  • All-cause mortality
  • Cardiovascular events

Evidence topics

Cardiovascular RiskDiabetes Self-Management Education and Support

Primary intervention

SMS text messaging behavioral intervention for health promotion

Primary outcomes

Adherence rate (MARS-5)All-cause mortalityCardiovascular events

Evidence relationships

Intervention and outcome relationships this study adds to the evidence network.

6
Evidence pairs
6
Relationships
3
Evidence topics
contributes_evidence

Editorial context

Why this study matters

See why this paper is useful beyond its individual results.

Evidence network role

This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.

Moderate contributionModerate confidenceNetwork score: 69

3

Related topics

6

Evidence pairs

175

Related studies

High relevance in at least one topic

Why it is useful

  • Contributes to 6 evidence relationships
  • Includes primary outcome data
  • Linked to 2 direct semantic evidence topics

Topic contributions

Evidence topic

Contributes evidence

Evidence topic

Contributes evidence

Evidence topic

Contributes evidence

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Evidencia principal

Relación de evidencia

Diabetes Self-Management Education and Support (DSMES) Programs and Adipokine and Angiogenic Markers

Evidencia relacionada

Relación de evidencia

Diabetes Self-Management Education and Support (DSMES) Programs and Cardiovascular Outcomes

Seguir evidencia

Tema de evidencia

Cardiovascular Risk

Seguir evidencia

Core evidence

Study findings

The primary outcomes reported in this study.

Adherence rate (MARS-5)

SMS text messaging behavioral intervention for health promotion → Adherence rate (MARS-5)

SMS text messaging behavioral intervention for health promotion → Adherence rate (MARS-5)

Evidence Intelligence™
ImpactScore™
100
Very Positive
EvidenceScore™
Emerging
Score 59 · Based on 1 study
ConsistencyScore™
unclear
Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence Tracker

All-cause mortality

SMS text messaging behavioral intervention for health promotion → All-cause mortality

SMS text messaging behavioral intervention for health promotion → All-cause mortality

Evidence Intelligence™
ImpactScore™
50
Neutral
EvidenceScore™
Emerging
Score 59 · Based on 1 study
ConsistencyScore™
unclear
Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence Tracker

Cardiovascular events

SMS text messaging behavioral intervention for health promotion → Cardiovascular events

SMS text messaging behavioral intervention for health promotion → Cardiovascular events

Evidence Intelligence™
ImpactScore™
50
Neutral
EvidenceScore™
Emerging
Score 59 · Based on 1 study
ConsistencyScore™
unclear
Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence Tracker

LDL cholesterol

SMS text messaging behavioral intervention for health promotion → LDL cholesterol

SMS text messaging behavioral intervention for health promotion → LDL cholesterol

Evidence Intelligence™
ImpactScore™
100
Very Positive
EvidenceScore™
Emerging
Score 59 · Based on 1 study
ConsistencyScore™
unclear
Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence Tracker

Pill count adherence

SMS text messaging behavioral intervention for health promotion → Pill count adherence

SMS text messaging behavioral intervention for health promotion → Pill count adherence

Evidence Intelligence™
ImpactScore™
100
Very Positive
EvidenceScore™
Emerging
Score 59 · Based on 1 study
ConsistencyScore™
unclear
Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence Tracker

Total cholesterol

SMS text messaging behavioral intervention for health promotion → Total cholesterol

SMS text messaging behavioral intervention for health promotion → Total cholesterol

Evidence Intelligence™
ImpactScore™
100
Very Positive
EvidenceScore™
Emerging
Score 59 · Based on 1 study
ConsistencyScore™
unclear
Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence Tracker

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Evidence Tracker

12 tracked topics

Saved Studies

48 studies

Research Notes

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Weekly Evidence Digest

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evidence suggest

La Evidencia Sugiere

  • Adherence rates increased by 5.23 points in the intervention group (P = 0.000).
  • Pill count adherence improved by 8.66 tablets (P = 0.000).
  • Total cholesterol decreased by 29.87 mg/dL (P = 0.000).
who this applies

A quién se aplica

  • Adults with diabetes requiring statin therapy.
  • Patients who may benefit from telehealth interventions.
keep in mind

Tener en Cuenta

  • The study focused on short-term adherence and may not reflect long-term behavior.
  • Participants were selected from a specific population, limiting generalizability.
  • No significant differences in serious cardiovascular events or mortality were observed.
between the lines

Entre Líneas

  • The study did not measure long-term adherence beyond the intervention period.
  • Results may not be generalizable to all diabetic populations.
  • The impact of SMS reminders on clinical outcomes like heart events was not significant.

Save this study

Keep this study in your Evidence Tracker so you can easily find it again whenever you need it.

Today's Activity

Your Evidence Workspace

Free account

Saved this study

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Evidence Tracker

12 tracked topics

Saved Studies

48 studies

Research Notes

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Coming Soon

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Connected Evidence

Explore related studies, evidence collections, and research questions.

Relationships organized using the Dediabetes Evidence Intelligence™ framework.

Powered by the Dediabetes Evidence Intelligence™ framework

This study contributes to evidence on Diabetes Self-Management Education and Support (DSMES) Programs and Adherence rate (MARS-5), Diabetes Self-Management Education and Support (DSMES) Programs and Cardiovascular Outcomes.

Relaciones de evidencia relacionadas

Explore in Evidence Archive

This study contributes to the evidence on the following intervention-outcome relationships.

Incluido en estas colecciones de evidencia

Curated evidence collections and hubs this study is part of.

Adherence rate (MARS-5) Evidence Hub

All studies measuring Adherence rate (MARS-5)

1 studies
outcome_hub

Measures Adherence rate (MARS-5) as a key outcome.

Adipokine and Angiogenic Markers Evidence Hub

All studies measuring Adipokine and Angiogenic Markers

1 studies
outcome_hub

Measures Adipokine and Angiogenic Markers as a key outcome.

Cardiovascular Outcomes Evidence Hub

All studies measuring Cardiovascular Outcomes

1 studies
outcome_hub

Measures Cardiovascular Outcomes as a key outcome.

Diabetes Self-Management Education and Support (DSMES) Programs Evidence Hub

All studies on Diabetes Self-Management Education and Support (DSMES) Programs

1 studies
intervention_hub

Contributes to Diabetes Self-Management Education and Support (DSMES) Programs evidence base.

Recent Diabetes Research

Latest published studies

recency_collection

Published within the last 2 years.

Explora más en el archivo de evidencia

Jump to pre-filtered views in the evidence archive.

All studies on SMS text messaging behavioral intervention for health promotion and Adherence rate (MARS-5)

Intervention: SMS text messaging behavioral intervention for health promotionOutcome: Adherence rate (MARS-5)

1 results

All studies on SMS text messaging behavioral intervention for health promotion and All-cause mortality

Intervention: SMS text messaging behavioral intervention for health promotionOutcome: All-cause mortality

1 results

All studies on SMS text messaging behavioral intervention for health promotion

Intervention: SMS text messaging behavioral intervention for health promotion

1 results

All studies measuring Adherence rate (MARS-5)

Outcome: Adherence rate (MARS-5)

1 results

All studies measuring All-cause mortality

Outcome: All-cause mortality

1 results

Questions answered by this study

Generated from the study's connected evidence using Evidence Intelligence™.

Does Diabetes Self-Management Education and Support (DSMES) Programs improve adipokine and angiogenic markers?

Strong Evidence

Diabetes Self-Management Education and Support (DSMES) Programs may improve Adipokine and Angiogenic Markers.

ConsistencyScore™: Results are consistent across studies.

Ranked evidence signals

  1. 1

    LDL cholesterol

    EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study

  2. 2

    Total cholesterol

    EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study

Why this answer: This answer is based on 7 supporting studies with consistent results and a positive effect signal.

Limitations

  • Population details are unavailable.
7 supporting studiesUpdated: Jul 2026
View Full Evidence

Does Diabetes Self-Management Education and Support (DSMES) Programs improve cardiovascular outcomes?

Strong Evidence

Diabetes Self-Management Education and Support (DSMES) Programs may improve Cardiovascular Outcomes.

ConsistencyScore™: Results are generally consistent across studies.

Ranked evidence signals

  1. 1

    All-cause mortality

    EvidenceScore™ Emerging | EvidenceScore™ 59.0 | neutral | ConsistencyScore™ Unclear | 1 study

  2. 2

    Cardiovascular events

    EvidenceScore™ Emerging | EvidenceScore™ 59.0 | neutral | ConsistencyScore™ Unclear | 1 study

Why this answer: This answer is based on 3 supporting studies with generally consistent results and a positive effect signal.

Limitations

  • Population details are unavailable.
3 supporting studiesUpdated: Jul 2026
View Full Evidence

Does SMS text messaging behavioral intervention for health promotion improve adherence rate (mars-5)?

Emerging Evidence

SMS text messaging behavioral intervention for health promotion appears to improve Adherence rate (MARS-5).

ConsistencyScore™: Consistency cannot yet be determined from the available evidence.

Ranked evidence signals

  1. 1

    Adherence rate (MARS-5)

    EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study

Why this answer: This answer is based on a single supporting study.

Limitations

  • Only one supporting study is available.
  • Consistency cannot yet be determined.
  • Population details are unavailable.
1 supporting studyUpdated: Jul 2026
View Full Evidence

Does SMS text messaging behavioral intervention for health promotion improve pill count adherence?

Emerging Evidence

SMS text messaging behavioral intervention for health promotion appears to improve Pill count adherence.

ConsistencyScore™: Consistency cannot yet be determined from the available evidence.

Ranked evidence signals

  1. 1

    Pill count adherence

    EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study

Why this answer: This answer is based on a single supporting study.

Limitations

  • Only one supporting study is available.
  • Consistency cannot yet be determined.
  • Population details are unavailable.
1 supporting studyUpdated: Jul 2026
View Full Evidence
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Next steps

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Evidence topics

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Cardiovascular Risk Evidence HubDiabetes Self-Management Education and Support Evidence HubDiabetes Technology Evidence Hub

Explore in archive

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All studies on SMS text messaging behavioral intervention for health promotion and Adherence rate (MARS-5)All studies on SMS text messaging behavioral intervention for health promotion and Pill count adherenceAll studies on SMS text messaging behavioral intervention for health promotion and All-cause mortalityAll studies on SMS text messaging behavioral intervention for health promotion and Cardiovascular events

Related research

Read related research summaries.

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