Última actualización 2 de septiembre de 2026
Key finding
A significant increase in appendicular muscle mass (+0.36 kg; 95% CI, 0.005 to 0.71)
This study investigated the effects of a whey protein drink enriched with leucine and vitamin D on muscle mass and glycemic control in older adults with obesity and type 2 diabetes.
Quick read
The essential study design details in one scan.
EvidenceScore™
Moderate
Study type
RCTs
Follow-up
Medium-Term (3–12 mo)
Risk of bias
Some Concerns
Guarda investigacion, organiza estudios y vuelve a encontrar evidencia importante rapidamente.
Plain-language summary
A plain-language read of the study’s main message and where it applies.
Study focus
This study investigated the effects of a whey protein drink enriched with leucine and vitamin D on muscle mass and glycemic control in older adults with obesity and type 2 diabetes.
Improving muscle mass and glycemic control in older adults with obesity and type 2 diabetes is crucial, as these factors significantly impact overall health, mobility, and the risk of complications. The findings suggest that dietary interventions, such as enriched protein drinks, could be a valuable strategy in managing these conditions.
Nonsignificant increase in leg muscle mass raises questions about its clinical relevance. Sample size and demographic characteristics may limit generalizability. Potential confounding factors not controlled for in the study.
Published in
Publication details and source links for this paper.
Robert GM, Wilrike JP, Anke B, et al. The Use of a Whey Protein Drink Enriched with Leucine and Vitamin D During a Combined Lifestyle Intervention Shows Beneficial Effects on Muscle Mass and Glycemic Control in Older Adults with Obesity and Type 2 Diabetes. Nutrients. 2020;13(1):64. doi:10.3390/nu13010064
Significant increase in appendicular muscle mass (+0.36 kg; p=0.047)
Significant increase in total lean mass (+0.92 kg; p=0.015)
Improved insulin sensitivity (Matsuda index +0.52; p=0.023)
Evidence network
Understand where this research contributes within the broader evidence network.
This study contributes evidence to Isocaloric control drink, whey protein 20g and Appendicular muscle mass, Insulin sensitivity, Lean body mass.
This study contributes evidence to
Primary intervention
Isocaloric control drink
Primary outcomes
Evidence topics
Primary intervention
Primary outcomes
Intervention and outcome relationships this study adds to the evidence network.
Editorial context
See why this paper is useful beyond its individual results.
Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
2
Related topics
6
Evidence pairs
520
Related studies
Evidence topic
Contributes evidence
Evidence topic
Contributes evidence
Guarda estudios y paginas de evidencia, organiza tu Evidence Tracker y manten en un solo lugar la investigacion que te importa.
Evidencia principal
Tema de evidencia
matched_outcome
Evidencia relacionada
Tema de evidencia
Guardar evidencia
Core evidence
The primary outcomes reported in this study.
Isocaloric control drink → Appendicular muscle mass
Isocaloric control drink → Appendicular muscle mass
Isocaloric control drink → Insulin sensitivity
Isocaloric control drink → Insulin sensitivity
whey protein 20g → Appendicular muscle mass
whey protein 20g → Appendicular muscle mass
Evidence Library
Save research, organize studies, and quickly find important evidence again.
Evidence Library
Save research, organize studies, and quickly find important evidence again.
Explore related studies, evidence collections, and research questions.
Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on whey protein 20g and Appendicular muscle mass, whey protein 20g and Insulin Resistance.
This study contributes to the evidence on the following intervention-outcome relationships.
Diet and Nutrition
Diet and Nutrition
Curated evidence collections and hubs this study is part of.
All studies measuring Appendicular muscle mass
Measures Appendicular muscle mass as a key outcome.
All studies measuring Insulin Resistance
Measures Insulin Resistance as a key outcome.
All studies on whey protein 20g
Contributes to whey protein 20g evidence base.
Jump to pre-filtered views in Evidence Explorer.
1 results
1 results
1 results
1 results
1 results
Generated from the study's connected evidence using Evidence Intelligence™.
whey protein 20g appears to improve appendicular muscle mass.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Appendicular muscle mass
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
whey protein 20g appears to improve insulin sensitivity.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Insulin sensitivity
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Current evidence does not show a clear benefit of Isocaloric control drink for appendicular muscle mass.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Appendicular muscle mass
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | neutral | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Current evidence does not show a clear benefit of Isocaloric control drink for insulin sensitivity.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Insulin sensitivity
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | neutral | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Next steps
Choose a next path through related evidence topics, Evidence Explorer views, and research summaries.
Follow the topics this study contributes to.
Open broader Evidence Explorer views for this relationship.
Read related research summaries.
Centrada en la evidencia, no en la publicidad.
Tus datos siempre están protegidos.
Se agregan nuevos estudios todos los días.
