Key finding
No significant effects or dose–response relationships were observed by ACNs supplementation on arterial stiffness.
This study investigated the effects of purified anthocyanins on vascular stiffness and cardiovascular risk in Chinese adults with dysglycemia, finding no significant improvements.
Evidence strength
Moderate confidence
Study type
RCTs
Follow-up
Medium-Term (3–12 mo)
Quick read
The essential study design details in one scan.
Population
Young Adult (19–39), Middle Aged (40-64), Male, Female, Asia-Pacific (APAC), with T2 Diabetes
Intervention
Purified anthocyanins supplementation
Study type
RCTs
Follow-up
Medium-Term (3–12 mo)
Primary outcome
Brachial-ankle pulse wave velocity (baPWV)
Evidence
Moderate confidence
Plain-language summary
A plain-language read of the study's main message and where it applies.
Study focus
This study investigated the effects of purified anthocyanins on vascular stiffness and cardiovascular risk in Chinese adults with dysglycemia, finding no significant improvements.
Understanding the impact of dietary supplements like anthocyanins on cardiovascular health is crucial, especially for populations at risk, such as those with dysglycemia. The lack of significant findings suggests that anthocyanins may not be an effective intervention for improving vascular health in this demographic, guiding future research and dietary recommendations.
Unclear effectiveness of anthocyanins due to lack of significant findings Limited generalizability to other populations outside Chinese adults with dysglycemia Potential unmeasured confounders affecting results
Published in
Publication details and source links for this paper.
Zhaomin L, Minmin L, Yuming C, et al. The Dose-Response Effects of Purified Anthocyanins on Vascular Stiffness and Cardiovascular Risk in Chinese Adults with Dysglycemia. Nutrients. 2025;18(1):112. doi:10.3390/nu18010112
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No significant change in brachial-ankle pulse wave velocity (0 cm/s, no_change)
No significant change in ankle-brachial index (0 index, no_change)
No significant change in systolic blood pressure (0 mmHg, no_change)
No significant change in diastolic blood pressure (0 mmHg, no_change)
Evidence network
Understand where this research contributes within the broader evidence network.
This study contributes evidence to Purified anthocyanins supplementation and Ankle-brachial index (ABI), Brachial-ankle pulse wave velocity (baPWV), Diastolic blood pressure, and 1 more.
This study contributes evidence to
Primary intervention
Purified anthocyanins supplementation
Primary outcomes
Evidence topics
Primary intervention
Intervention and outcome relationships this study adds to the evidence network.
Editorial context
See why this paper is useful beyond its individual results.
Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
1
Related topics
4
Evidence pairs
33
Related studies
Evidence topic
Contributes evidence
Core evidence
The primary outcomes reported in this study.
Purified anthocyanins supplementation → Ankle-brachial index (ABI)
Purified anthocyanins supplementation → Ankle-brachial index (ABI)
Evidence profile
Purified anthocyanins supplementation → Brachial-ankle pulse wave velocity (baPWV)
Purified anthocyanins supplementation → Brachial-ankle pulse wave velocity (baPWV)
Evidence profile
Purified anthocyanins supplementation → Diastolic blood pressure
Purified anthocyanins supplementation → Diastolic blood pressure
Evidence profile
Purified anthocyanins supplementation → Systolic blood pressure
Purified anthocyanins supplementation → Systolic blood pressure
Evidence profile
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Relationships organized using the Dediabetes Evidence Intelligence™ framework.
Generated from the study's connected evidence using Evidence Intelligence™.
Current evidence does not show a clear benefit of Purified anthocyanins supplementation for Ankle-brachial index (ABI).
ConsensusScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Ankle-brachial index (ABI)
EvidenceScore™ Limited | EvidenceScore™ 31.6 | neutral | ConsensusScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Current evidence does not show a clear benefit of Purified anthocyanins supplementation for Brachial-ankle pulse wave velocity (baPWV).
ConsensusScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Brachial-ankle pulse wave velocity (baPWV)
EvidenceScore™ Limited | EvidenceScore™ 31.6 | neutral | ConsensusScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Current evidence does not show a clear benefit of Purified anthocyanins supplementation for Diastolic blood pressure.
ConsensusScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Diastolic blood pressure
EvidenceScore™ Limited | EvidenceScore™ 31.6 | neutral | ConsensusScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Current evidence does not show a clear benefit of Purified anthocyanins supplementation for Systolic blood pressure.
ConsensusScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Systolic blood pressure
EvidenceScore™ Limited | EvidenceScore™ 31.6 | neutral | ConsensusScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
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