Last updated August 21, 2026
Key finding
HR 0.37 (0.24–0.59), p < 0.001
This study explored the role of circulating long non-coding RNAs (lncRNAs) as predictive biomarkers for type 2 diabetes mellitus (T2DM) in high cardiovascular risk patients, finding a significant association between lower lncRNA scores and reduced T2DM risk.
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EvidenceScore™
Moderate
Study type
RCTs
Follow-up
Extended (5–20+ y)
Risk of bias
Some Concerns
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Plain-language summary
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Study focus
This study explored the role of circulating long non-coding RNAs (lncRNAs) as predictive biomarkers for type 2 diabetes mellitus (T2DM) in high cardiovascular risk patients, finding a significant association between lower lncRNA scores and reduced T2DM risk.
Identifying predictive biomarkers for type 2 diabetes is crucial for early intervention, particularly in high-risk populations. This study highlights the potential of circulating lncRNAs as a non-invasive tool for clinicians to assess diabetes risk, allowing for timely preventive measures and better management of cardiovascular health.
The effectiveness of interventions was unclear due to limited data. The study's generalizability may be limited to specific high-risk populations. Potential confounding factors were not fully accounted for.
Published in
Publication details and source links for this paper.
Hatim B, María JP, Ana O, et al. Circulating long non-coding RNAs as predictive biomarkers for type 2 diabetes mellitus development in high cardiovascular risk patients. Cardiovascular Diabetology. 2025;24:455. doi:10.1186/s12933-025-02942-y
A lower lncRNA score was associated with a reduced risk of developing T2DM (HR 0.37, p < 0.001).
The association between lncRNA scores and T2DM risk was consistently observed across multiple analyses.
Evidence network
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This study contributes evidence to Low-fat diet, Mediterranean diet and lncRNA score associated with T2DM risk, type 2 diabetes mellitus.
This study contributes evidence to
Primary intervention
Low-fat diet
Primary outcomes
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Primary intervention
Primary outcomes
Intervention and outcome relationships this study adds to the evidence network.
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Evidence network role
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4
Evidence pairs
351
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Contributes evidence
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Contributes evidence
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Primary evidence
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Core evidence
The primary outcomes reported in this study.
Low-fat diet → lncRNA score associated with T2DM risk
Low-fat diet → lncRNA score associated with T2DM risk
Low-fat diet → type 2 diabetes mellitus
Low-fat diet → type 2 diabetes mellitus
Mediterranean diet → lncRNA score associated with T2DM risk
Mediterranean diet → lncRNA score associated with T2DM risk
Mediterranean diet → type 2 diabetes mellitus
Mediterranean diet → type 2 diabetes mellitus
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Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on Low-fat Diets and Diabetes Incidence and Prevention, Low-fat Diets and lncRNA score associated with T2DM risk.
This study contributes to the evidence on the following intervention-outcome relationships.
Diet and Nutrition
Diet and Nutrition
Curated evidence collections and hubs this study is part of.
All studies measuring Diabetes Incidence and Prevention
Measures Diabetes Incidence and Prevention as a key outcome.
All studies measuring lncRNA score associated with T2DM risk
Measures lncRNA score associated with T2DM risk as a key outcome.
All studies on Low-fat Diets
Contributes to Low-fat Diets evidence base.
Latest published studies
Published within the last 2 years.
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1 results
1 results
1 results
1 results
1 results
Generated from the study's connected evidence using Evidence Intelligence™.
Low-fat Diets appear to reduce diabetes incidence and prevention.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
type 2 diabetes mellitus
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Low-fat diet appears to reduce lncrna score associated with t2dm risk.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
lncRNA score associated with T2DM risk
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Mediterranean diet appears to reduce lncrna score associated with t2dm risk.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
lncRNA score associated with T2DM risk
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Mediterranean diet appears to improve type 2 diabetes mellitus.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
type 2 diabetes mellitus
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
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