Last updated August 16, 2026
Key finding
Plasma aldosterone (lying) decreased from 188.45 ± 67.74 ng/mL to 131.60 ± 49.15 ng/mL after treatment.
This study investigated the impact of continuous positive airway pressure (CPAP) on plasma aldosterone levels in patients with obstructive sleep apnea and type 2 diabetes, finding significant reductions in plasma aldosterone levels.
Quick read
The essential study design details in one scan.
EvidenceScore™
Moderate
Study type
RCTs
Follow-up
Extended (5–20+ y)
Risk of bias
Some Concerns
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Plain-language summary
A plain-language read of the study’s main message and where it applies.
Study focus
This study investigated the impact of continuous positive airway pressure (CPAP) on plasma aldosterone levels in patients with obstructive sleep apnea and type 2 diabetes, finding significant reductions in plasma aldosterone levels.
The findings highlight the potential of CPAP therapy not only in improving sleep quality but also in influencing hormonal levels that are crucial for cardiovascular health. Reducing plasma aldosterone may help mitigate risks associated with hypertension and cardiovascular diseases in patients with obstructive sleep apnea and type 2 diabetes.
The study did not assess long-term effects of CPAP on hormonal levels. Sample size and demographic characteristics may limit generalizability. Urinary aldosterone changes were not statistically significant.
Published in
Publication details and source links for this paper.
Jie Z, Lin T, Lixin G. The effect of continuous positive airway pressure on plasma aldosterone levels in patients with obstructive sleep apnea and type 2 diabetes. The Journal of International Medical Research. 2019;47(10):4723-4733. doi:10.1177/0300060519868337
Plasma aldosterone (lying) decreased by 56.85 ng/mL (p=0.001).
Plasma aldosterone (standing) decreased by 33.1 ng/mL (p=0.01).
Plasma renin (lying) decreased by 0.45 ng/mL·h (p=0.03).
Plasma renin (standing) decreased by 0.54 ng/mL·h (p=0.02).
Evidence network
Understand where this research contributes within the broader evidence network.
This study contributes evidence to Continuous Positive Airway Pressure (CPAP) and Fasting blood sugar (FBS), Glucose iAUC (OGTT), Plasma aldosterone levels in lying position, and 3 more.
This study contributes evidence to
Primary intervention
Continuous Positive Airway Pressure (CPAP)
Primary outcomes
Primary intervention
Intervention and outcome relationships this study adds to the evidence network.
Editorial context
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Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
3
Related topics
6
Evidence pairs
888
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Evidence topic
Contributes evidence
Evidence topic
Contributes evidence
Evidence topic
Contributes evidence
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Primary evidence
Evidence topic
matched_outcome
Related evidence
Evidence topic
Save evidence
Core evidence
The primary outcomes reported in this study.
Continuous Positive Airway Pressure (CPAP) → Fasting blood sugar (FBS)
Continuous Positive Airway Pressure (CPAP) → Fasting blood sugar (FBS)
Continuous Positive Airway Pressure (CPAP) → Glucose iAUC (OGTT)
Continuous Positive Airway Pressure (CPAP) → Glucose iAUC (OGTT)
Continuous Positive Airway Pressure (CPAP) → Plasma aldosterone levels in lying position
Continuous Positive Airway Pressure (CPAP) → Plasma aldosterone levels in lying position
Continuous Positive Airway Pressure (CPAP) → Plasma aldosterone levels in standing position
Continuous Positive Airway Pressure (CPAP) → Plasma aldosterone levels in standing position
Continuous Positive Airway Pressure (CPAP) → Renin
Continuous Positive Airway Pressure (CPAP) → Renin
Continuous Positive Airway Pressure (CPAP) → Urinary aldosterone levels
Continuous Positive Airway Pressure (CPAP) → Urinary aldosterone levels
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Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on Continuous Positive Airway Pressure (CPAP) and Fasting Glucose, Continuous Positive Airway Pressure (CPAP) and Postprandial and OGTT Glucose.
This study contributes to the evidence on the following intervention-outcome relationships.
Devices & Technology
Devices & Technology
Curated evidence collections and hubs this study is part of.
All studies on Continuous Positive Airway Pressure (CPAP)
Contributes to Continuous Positive Airway Pressure (CPAP) evidence base.
All studies measuring Fasting Glucose
Measures Fasting Glucose as a key outcome.
All studies measuring Postprandial and OGTT Glucose
Measures Postprandial and OGTT Glucose as a key outcome.
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1 results
1 results
1 results
1 results
1 results
Generated from the study's connected evidence using Evidence Intelligence™.
Continuous Positive Airway Pressure (CPAP) appears to improve plasma aldosterone levels in lying position.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Plasma aldosterone levels in lying position
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Continuous Positive Airway Pressure (CPAP) appears to improve plasma aldosterone levels in standing position.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Plasma aldosterone levels in standing position
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Continuous Positive Airway Pressure (CPAP) appears to improve renin.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Renin
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Current evidence does not show a clear benefit of Continuous Positive Airway Pressure (CPAP) for fasting blood sugar (FBS).
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Fasting blood sugar (FBS)
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | neutral | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
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