Last updated August 16, 2026
Key finding
CPAP reduced daytime resting heart rate by 4.1 beats/min (95% CI, -6.5 to -1.7 beats/min; P = 0.002).
This study investigated the impact of Continuous Positive Airway Pressure (CPAP) on daytime resting heart rate in patients with obstructive sleep apnea and prediabetes, finding a significant reduction.
Quick read
The essential study design details in one scan.
EvidenceScore™
Moderate
Study type
RCTs
Follow-up
Short-Term (≤3 mo)
Risk of bias
Some Concerns
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Plain-language summary
A plain-language read of the study’s main message and where it applies.
Study focus
This study investigated the impact of Continuous Positive Airway Pressure (CPAP) on daytime resting heart rate in patients with obstructive sleep apnea and prediabetes, finding a significant reduction.
This finding is clinically significant as it suggests that CPAP therapy not only alleviates symptoms of obstructive sleep apnea but may also contribute to better cardiovascular health in patients with prediabetes. Reducing daytime resting heart rate can lower the risk of cardiovascular complications, making CPAP an important treatment option for this population.
The study's sample size may limit the generalizability of the findings. The specific population studied may not represent all patients with obstructive sleep apnea. Potential confounding factors were not fully controlled for.
Published in
Publication details and source links for this paper.
Sushmita P, Florian C, Kristen W, Harry W, Tamar P, Esra T. Continuous Positive Airway Pressure Treatment Reduces Daytime Resting Heart Rate in Patients with Obstructive Sleep Apnea and Prediabetes. Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease. 2020;9(19):e016871. doi:10.1161/JAHA.120.016871
CPAP reduced daytime resting heart rate by 4.1 beats/min (P = 0.002).
Reduction in daytime resting heart rate correlated with decreased plasma norepinephrine (r = 0.44; P = 0.02).
Reduction in daytime resting heart rate correlated with decreased apnea-hypopnea index (r = 0.48; P = 0.005).
Reduction in daytime resting heart rate correlated with decreased oxygen desaturation index (r = 0.50; P = 0.003).
Reduction in daytime resting heart rate correlated with decreased microarousal index (r = 0.57; P < 0.001).
Evidence network
Understand where this research contributes within the broader evidence network.
This study contributes evidence to Continuous Positive Airway Pressure (CPAP) and Apnea Hypopnea Index (AHI), Decrease in Plasma Norepinephrine Levels, Heart rate, and 2 more.
This study contributes evidence to
Primary intervention
Continuous Positive Airway Pressure (CPAP)
Primary outcomes
Primary intervention
Intervention and outcome relationships this study adds to the evidence network.
Editorial context
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Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
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Related topics
5
Evidence pairs
0
Related studies
Core evidence
The primary outcomes reported in this study.
Continuous Positive Airway Pressure (CPAP) → Apnea Hypopnea Index (AHI)
Continuous Positive Airway Pressure (CPAP) → Apnea Hypopnea Index (AHI)
Continuous Positive Airway Pressure (CPAP) → Decrease in Plasma Norepinephrine Levels
Continuous Positive Airway Pressure (CPAP) → Decrease in Plasma Norepinephrine Levels
Continuous Positive Airway Pressure (CPAP) → Heart rate
Continuous Positive Airway Pressure (CPAP) → Heart rate
Continuous Positive Airway Pressure (CPAP) → Microarousal Index
Continuous Positive Airway Pressure (CPAP) → Microarousal Index
Continuous Positive Airway Pressure (CPAP) → Oxygen Desaturation Index
Continuous Positive Airway Pressure (CPAP) → Oxygen Desaturation Index
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Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on Continuous Positive Airway Pressure (CPAP) and Apnea Hypopnea Index (AHI), Continuous Positive Airway Pressure (CPAP) and Heart rate.
This study contributes to the evidence on the following intervention-outcome relationships.
Devices & Technology
Devices & Technology
Curated evidence collections and hubs this study is part of.
All studies measuring Apnea Hypopnea Index (AHI)
Measures Apnea Hypopnea Index (AHI) as a key outcome.
All studies on Continuous Positive Airway Pressure (CPAP)
Contributes to Continuous Positive Airway Pressure (CPAP) evidence base.
All studies measuring Heart rate
Measures Heart rate as a key outcome.
Jump to pre-filtered views in Evidence Explorer.
1 results
1 results
1 results
1 results
1 results
Generated from the study's connected evidence using Evidence Intelligence™.
Continuous Positive Airway Pressure (CPAP) appears to improve apnea hypopnea index (AHI).
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Apnea Hypopnea Index (AHI)
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Continuous Positive Airway Pressure (CPAP) appears to improve decrease in plasma norepinephrine levels.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Decrease in Plasma Norepinephrine Levels
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Continuous Positive Airway Pressure (CPAP) appears to improve heart rate.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Heart rate
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Continuous Positive Airway Pressure (CPAP) appears to improve microarousal index.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Microarousal Index
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
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