Last updated August 15, 2026
Key finding
DDG reduced HbA1c compared with placebo (−0.32%, P=0.032).
This study evaluated the efficacy of Daixie Decoction granules as an add-on therapy to Metformin in patients with Type 2 Diabetes, finding a significant reduction in HbA1c levels.
Quick read
The essential study design details in one scan.
EvidenceScore™
Moderate
Study type
RCTs
Follow-up
Medium-Term (3–12 mo)
Risk of bias
Some Concerns
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Plain-language summary
A plain-language read of the study’s main message and where it applies.
Study focus
This study evaluated the efficacy of Daixie Decoction granules as an add-on therapy to Metformin in patients with Type 2 Diabetes, finding a significant reduction in HbA1c levels.
The findings suggest that Daixie Decoction granules could be a beneficial addition to Metformin therapy for managing Type 2 Diabetes. This could lead to improved glycemic control for patients who may not achieve optimal results with Metformin alone, potentially reducing the risk of diabetes-related complications.
Results for C-peptide and insulin resistance were not specified. The sample size and demographic details were not provided. Potential confounding factors were not addressed.
Published in
Publication details and source links for this paper.
Zhong Z, Kepei Z, Xiaogang M, Yuezhou Q, Miao W. Efficacy of Daixie Decoction Granules as Add-On Therapy to Metformin in Patients with Type 2 Diabetes. Frontiers in Pharmacology. 2026;16:1723584. doi:10.3389/fphar.2025.1723584
Daixie Decoction granules reduced HbA1c by 0.32% (P=0.032).
Fasting plasma glucose showed a borderline reduction (P=0.050).
Safety was assessed through liver and renal function tests.
Evidence network
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This study contributes evidence to Daixie Decoction granules plus Metformin and C-peptide, Fasting Plasma Glucose (FPG), Fasting insulin levels, and 4 more.
This study contributes evidence to
Primary intervention
Daixie Decoction granules plus Metformin
Primary outcomes
Evidence topics
Primary intervention
Primary outcomes
Intervention and outcome relationships this study adds to the evidence network.
Editorial context
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Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
2
Related topics
7
Evidence pairs
622
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Contributes evidence
Evidence topic
Contributes evidence
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Primary evidence
Evidence topic
matched_outcome
Related evidence
Evidence topic
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Core evidence
The primary outcomes reported in this study.
Daixie Decoction granules plus Metformin → C-peptide
Daixie Decoction granules plus Metformin → C-peptide
Daixie Decoction granules plus Metformin → Fasting insulin levels
Daixie Decoction granules plus Metformin → Fasting insulin levels
Daixie Decoction granules plus Metformin → Fasting Plasma Glucose (FPG)
Daixie Decoction granules plus Metformin → Fasting Plasma Glucose (FPG)
Daixie Decoction granules plus Metformin → HbA1c
Daixie Decoction granules plus Metformin → HbA1c
Daixie Decoction granules plus Metformin → Insulin resistance
Daixie Decoction granules plus Metformin → Insulin resistance
Daixie Decoction granules plus Metformin → Liver function tests
Daixie Decoction granules plus Metformin → Liver function tests
Daixie Decoction granules plus Metformin → Renal function tests
Daixie Decoction granules plus Metformin → Renal function tests
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Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on Daixie Decoction granules plus Metformin and C-peptide, Daixie Decoction granules plus Metformin and Insulin Resistance.
This study contributes to the evidence on the following intervention-outcome relationships.
Curated evidence collections and hubs this study is part of.
All studies measuring C-peptide
Measures C-peptide as a key outcome.
All studies on Daixie Decoction granules plus Metformin
Contributes to Daixie Decoction granules plus Metformin evidence base.
All studies measuring Insulin Resistance
Measures Insulin Resistance as a key outcome.
Latest published studies
Published within the last 2 years.
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1 results
1 results
1 results
1 results
1 results
Generated from the study's connected evidence using Evidence Intelligence™.
Daixie Decoction granules plus Metformin appears to improve HbA1c.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
HbA1c
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Current evidence does not show a clear benefit of Daixie Decoction granules plus Metformin for C-peptide.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
C-peptide
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | neutral | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Current evidence does not show a clear benefit of Daixie Decoction granules plus Metformin for Fasting Plasma Glucose (FPG).
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Fasting Plasma Glucose (FPG)
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | neutral | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Current evidence does not show a clear benefit of Daixie Decoction granules plus Metformin for Fasting insulin levels.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Fasting insulin levels
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | neutral | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
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