Last updated August 22, 2026
Key finding
There were no statistically significant differences in the primary and secondary outcomes between groups.
This study examined the impact of dietary fiber intervention on prediabetes and found no significant differences in health outcomes compared to usual care.
Quick read
The essential study design details in one scan.
EvidenceScore™
Moderate
Study type
RCTs
Follow-up
Long-Term (1–5 y)
Risk of bias
Some Concerns
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Plain-language summary
A plain-language read of the study’s main message and where it applies.
Study focus
This study examined the impact of dietary fiber intervention on prediabetes and found no significant differences in health outcomes compared to usual care.
Understanding the effectiveness of dietary interventions in managing prediabetes is crucial for developing effective treatment strategies. This study highlights that simply increasing dietary fiber may not be sufficient to improve key health outcomes in this population, suggesting the need for more comprehensive approaches.
Limited sample size may affect the generalizability of the findings. The study did not measure long-term effects of dietary fiber intervention. Potential confounding factors were not fully controlled.
Published in
Publication details and source links for this paper.
Delei S, Guangli F, Yuhang M, et al. Gut microbiota response influences dietary fiber intervention effectiveness in prediabetes. Nature Communications. 2025;16:11506. doi:10.1038/s41467-025-66498-x
No significant change in whole-blood HbA1c levels between dietary fiber intervention and control.
No significant differences in glucose levels observed between groups.
Insulin response did not differ significantly between the dietary fiber and usual care groups.
Evidence network
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This study contributes evidence to MDT nursing model combined with high-fiber dietary intervention, Usual care and Anthropometric parameters, Blood glucose, Changes in kidney function parameters, and 4 more.
This study contributes evidence to
Primary intervention
MDT nursing model combined with high-fiber dietary intervention
Primary outcomes
Evidence topics
Primary intervention
Intervention and outcome relationships this study adds to the evidence network.
Editorial context
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Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
2
Related topics
8
Evidence pairs
827
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Contributes evidence
Evidence topic
Contributes evidence
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Primary evidence
Evidence topic
matched_outcome
Related evidence
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Core evidence
The primary outcomes reported in this study.
MDT nursing model combined with high-fiber dietary intervention → Anthropometric parameters
MDT nursing model combined with high-fiber dietary intervention → Anthropometric parameters
MDT nursing model combined with high-fiber dietary intervention → Blood glucose
MDT nursing model combined with high-fiber dietary intervention → Blood glucose
MDT nursing model combined with high-fiber dietary intervention → Changes in kidney function parameters
MDT nursing model combined with high-fiber dietary intervention → Changes in kidney function parameters
MDT nursing model combined with high-fiber dietary intervention → HbA1c
MDT nursing model combined with high-fiber dietary intervention → HbA1c
MDT nursing model combined with high-fiber dietary intervention → Insulin
MDT nursing model combined with high-fiber dietary intervention → Insulin
MDT nursing model combined with high-fiber dietary intervention → lipids
MDT nursing model combined with high-fiber dietary intervention → lipids
MDT nursing model combined with high-fiber dietary intervention → Liver function tests
MDT nursing model combined with high-fiber dietary intervention → Liver function tests
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Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on Usual care and HbA1c, MDT nursing model combined with high-fiber dietary intervention and HbA1c.
This study contributes to the evidence on the following intervention-outcome relationships.
Behavioral & Lifestyle
Behavioral & Lifestyle
Behavioral & Lifestyle
Curated evidence collections and hubs this study is part of.
All studies measuring HbA1c
Measures HbA1c as a key outcome.
All studies on Usual care
Contributes to Usual care evidence base.
All studies on MDT nursing model combined with high-fiber dietary intervention
Contributes to MDT nursing model combined with high-fiber dietary intervention evidence base.
All studies measuring lipids
Measures lipids as a key outcome.
Latest published studies
Published within the last 2 years.
Jump to pre-filtered views in Evidence Explorer.
12 results
2 results
12 results
2 results
12 results
Generated from the study's connected evidence using Evidence Intelligence™.
Usual care may improve HbA1c.
ConsistencyScore™: Results are consistent across studies.
Ranked evidence signals
HbA1c
EvidenceScore™ Strong | EvidenceScore™ 85.9 | weak positive | ConsistencyScore™ Consistent | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
MDT nursing model combined with high-fiber dietary intervention may improve HbA1c.
ConsistencyScore™: Results are mixed and should be interpreted cautiously.
Ranked evidence signals
HbA1c
EvidenceScore™ Moderate | EvidenceScore™ 69.0 | moderate positive | ConsistencyScore™ Mixed | 1 study
Why this answer: This answer is cautious because the available studies report mixed findings.
Limitations
Current evidence does not show a clear benefit of MDT nursing model combined with high-fiber dietary intervention for Anthropometric parameters.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Anthropometric parameters
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | neutral | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Current evidence does not show a clear benefit of MDT nursing model combined with high-fiber dietary intervention for Blood glucose.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Blood glucose
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | neutral | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
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