Evidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 100
- Very Positive
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence TrackerResearch Summary
Analyzed using Evidence Intelligence™
Dietary interventions improve diabetes remission rates
Last updated July 17, 2026
Key finding
Diabetes remission occurred in 9 (22.5%) of 40 participants in the CCR group.
The DIREM Study evaluated the effects of different dietary interventions on diabetes remission. Results showed higher remission rates in the calorie-carbohydrate restriction and intermittent fasting groups compared to usual care.
Quick read
Study at a glance
The essential study design details in one scan.
EvidenceScore™
Moderate
Study type
RCTs
Follow-up
Short-Term (≤3 mo)
Risk of bias
Some Concerns
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Plain-language summary
What this paper says
A plain-language read of the study’s main message and where it applies.
Study focus
The DIREM Study evaluated the effects of different dietary interventions on diabetes remission. Results showed higher remission rates in the calorie-carbohydrate restriction and intermittent fasting groups compared to usual care.
Clinical relevance
These findings are significant as they suggest that dietary interventions can be effective strategies for achieving diabetes remission, which is crucial for improving patient outcomes and reducing the burden of diabetes-related complications. This could lead to new dietary guidelines and treatment approaches for managing diabetes.
Keep in mind
The study had a relatively small sample size of 120 participants. Findings may not be generalizable to all populations with diabetes. The long-term effects of the dietary interventions were not assessed.
Published in
Journal Reference
Publication details and source links for this paper.
Negin B, Alireza E, Kurosh D, et al. Diet and Diabetes Remission (DIREM) Study: A Randomized Controlled Trial. Endocrinology, Diabetes & Metabolism. 2026;9(3):e70209. doi:10.1002/edm2.70209
Main Effects
Diabetes remission occurred in 22.5% of participants in the CCR group (p=0.024).
Diabetes remission occurred in 30.0% of participants in the IFCCR group (p=0.007).
Only 2.5% of participants in the usual care group achieved diabetes remission.
Evidence network
How this study fits
Understand where this research contributes within the broader evidence network.
Evidence Context
This study contributes evidence to Calorie restriction, Usual care and Diabetes remission, HbA1c.
This study contributes evidence to
Primary intervention
Calorie restriction
Primary outcomes
- Diabetes remission
- HbA1c
Evidence topics
Primary intervention
Primary outcomes
Evidence relationships
Intervention and outcome relationships this study adds to the evidence network.
4
Evidence pairs
4
Relationships
3
Evidence topics
contributes_evidence
Editorial context
Why this study matters
See why this paper is useful beyond its individual results.
Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
Moderate contributionModerate confidenceNetwork score: 72
3
Related topics
4
Evidence pairs
727
Related studies
High relevance in at least one topic
Why it is useful
- Contributes to 4 evidence relationships
- Includes primary outcome data
- Linked to 3 direct semantic evidence topics
Topic contributions
Evidence topic
Contributes evidence
Evidence topic
Contributes evidence
Evidence topic
Contributes evidence
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Primary evidence
Evidence topic
Dietary Patterns
matched_intervention_and_outcome
Related evidence
Evidence topic
Diabetes Remission
Save evidence
Core evidence
Study findings
The primary outcomes reported in this study.
Evidence Intelligence™
- EvidenceScore™
- Strong
- Score 79 · Based on 4 studies
- ImpactScore™
- 88
- Very Positive
- ConsistencyScore™
- 75
- consistent
Supporting studies: Based on 4 studies
Add to Evidence TrackerEvidence Intelligence™
- EvidenceScore™
- Moderate
- Score 69 · Based on 2 studies
- ImpactScore™
- 50
- Neutral
- ConsistencyScore™
- 100
- consistent
Supporting studies: Based on 2 studies
Add to Evidence TrackerEvidence Intelligence™
- EvidenceScore™
- 86
- Strong
- ImpactScore™
- 56
- Slightly Positive
- ConsistencyScore™
- 89
- consistent
Supporting studies: Based on 9 studies
Add to Evidence TrackerEvidence Library
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Evidence Suggest
- 22.5% of CCR participants achieved diabetes remission.
- 30.0% of IFCCR participants achieved diabetes remission.
- HbA1c levels significantly decreased in both intervention groups.
Who this applies to
- Adults diagnosed with type 2 diabetes.
- Individuals seeking dietary interventions for diabetes management.
Keep in Mind
- The study's findings are based on a specific population and may not apply to everyone.
- Long-term sustainability of the dietary interventions was not evaluated.
- Further research is needed to confirm the findings in larger, diverse populations.
Between the Lines
- The study had a relatively small sample size of 120 participants.
- Findings may not be generalizable to all populations with diabetes.
- The long-term effects of the dietary interventions were not assessed.
Evidence Library
Build your evidence library
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Connected Evidence
Explore related studies, evidence collections, and research questions.
Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on Usual care and HbA1c, Calorie restriction and HbA1c.
Related evidence relationships
Explore in Evidence ExplorerThis study contributes to the evidence on the following intervention-outcome relationships.
Behavioral & Lifestyle
Usual care → HbA1c
Behavioral & Lifestyle
Evidence Intelligence™
- EvidenceScore™
- 86
- Strong
- ImpactScore™
- 56
- Slightly Positive
- ConsistencyScore™
- 89
- consistent
Supporting studies: Based on 9 studies
View evidenceDiet and Nutrition
Calorie restriction → HbA1c
Diet and Nutrition
Evidence Intelligence™
- EvidenceScore™
- Strong
- Score 79 · Based on 4 studies
- ImpactScore™
- 88
- Very Positive
- ConsistencyScore™
- 75
- consistent
Supporting studies: Based on 4 studies
View evidenceIncluded in these evidence collections
Curated evidence collections and hubs this study is part of.
HbA1c Evidence Hub
All studies measuring HbA1c
9 studies
outcome_hubMeasures HbA1c as a key outcome.
Usual care Evidence Hub
All studies on Usual care
9 studies
intervention_hubContributes to Usual care evidence base.
Calorie restriction Evidence Hub
All studies on Calorie restriction
4 studies
intervention_hubContributes to Calorie restriction evidence base.
Recent Diabetes Research
Latest published studies
recency_collection
Published within the last 2 years.
Explore more in Evidence Explorer
Jump to pre-filtered views in Evidence Explorer.
All studies on Usual care and HbA1c
Intervention: Usual careOutcome: HbA1c
9 results
All studies on Calorie restriction and HbA1c
Intervention: Calorie restrictionOutcome: HbA1c
4 results
All studies on Usual care
Intervention: Usual care
9 results
All studies on Calorie restriction
Intervention: Calorie restriction
4 results
All studies measuring HbA1c
Outcome: HbA1c
9 results
Questions answered by this study
Generated from the study's connected evidence using Evidence Intelligence™.
Does Usual care improve HbA1c?
Strong Evidence
Usual care may improve HbA1c.
ConsistencyScore™: Results are consistent across studies.
Ranked evidence signals
- 1
HbA1c
EvidenceScore™ Strong | EvidenceScore™ 85.7 | weak positive | ConsistencyScore™ Consistent | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
- Only one supporting study is available.
- Population details are unavailable.
Does Calorie restriction improve HbA1c?
Strong Evidence
Calorie restriction appears to improve HbA1c.
ConsistencyScore™: Results are consistent across studies.
Ranked evidence signals
- 1
HbA1c
EvidenceScore™ Strong | EvidenceScore™ 79.0 | strong positive | ConsistencyScore™ Consistent | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
- Only one supporting study is available.
- Population details are unavailable.
Does Usual care improve diabetes remission?
Moderate Evidence
Current evidence does not show a clear benefit of Usual care for Diabetes remission.
ConsistencyScore™: Results are consistent across studies.
Ranked evidence signals
- 1
Diabetes remission
EvidenceScore™ Moderate | EvidenceScore™ 69.0 | neutral | ConsistencyScore™ Consistent | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
- Only one supporting study is available.
- Population details are unavailable.
Does Calorie restriction improve diabetes remission?
Emerging Evidence
Calorie restriction appears to improve Diabetes remission.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
- 1
Diabetes remission
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
- Only one supporting study is available.
- Consistency cannot yet be determined.
- Population details are unavailable.
Next steps
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